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Disrupted in Schizophrenia 1 (DISC1) ELISA Kits

DISC1 encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. Additionally we are shipping Disrupted in Schizophrenia 1 Antibodies (167) and Disrupted in Schizophrenia 1 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
DISC1 27185 Q9NRI5
DISC1 244667 Q811T9
DISC1 307940 Q810H6
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Top Disrupted in Schizophrenia 1 ELISA Kits at antibodies-online.com

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Mouse
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$875.60
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Human
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More ELISA Kits for Disrupted in Schizophrenia 1 Interaction Partners

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.

  2. Disc1 and nrg1 (show NRG1 ELISA Kits) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 ELISA Kits)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 ELISA Kits) and sox10 (show SOX10 ELISA Kits), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. It is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3beta activity.

  2. DISC1 disruption affects expression of neural cell fate markers and Wnt (show WNT2 ELISA Kits) signaling.

  3. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  4. DISC1 gene variations may affect the course of cognitive deficits found in patients suffering from the first episode of non-affective psychosis

  5. DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites.

  6. An association was found with DISC1 genetic variants and susceptibility to schizophrenia in a Han Chinese population.

  7. Results indicate that the neurexin (show NRXN1 ELISA Kits) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia.

  8. Results with immature neurons from patients with schizophrenia and bipolar disorder showed common alterations in DISC1 levels and its cellular distribution, cAMP homeostasis, and cell migration

  9. we discuss the expression of DISC1, DBZ, and SGK1 (show SGK1 ELISA Kits) , their roles in the regulation of oligodendrocyte function, possible interactions of DISC1 and DBZ in relation to SZ, and the activation of the SGK1 (show SGK1 ELISA Kits) signaling cascade in relation to MDD.

  10. results demonstrate that DISC1 protein levels in human lymphocytes are correlated with the diagnosis of schizophrenia independent of smoking and thus present a potential biomarker

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. These results suggest that alteration of CB1R (show CNR1 ELISA Kits)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  2. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

  3. These results suggest a mechanism by which cross-talk between DISC1 and NRG1 (show NRG1 ELISA Kits)-ErbB4 (show ERBB4 ELISA Kits) signalling may contribute to these deficits.

  4. Study found that DISC1 influences APP (show APP ELISA Kits) C-terminal processing and Abeta (show APP ELISA Kits) peptide generation, affects surface expression and internalization of APP (show APP ELISA Kits) in neurons

  5. DISC1 regulates the expression of brain neurotrophin (show BDNF ELISA Kits) VGF (show VGF ELISA Kits) through the PI3K/AKT (show AKT1 ELISA Kits)/CREB (show CREB1 ELISA Kits) pathway.

  6. Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate (show GRIN1 ELISA Kits) system dysfunction and altered brain connectivity.

  7. DISC1 is a regulatory factor in ER calcium dynamics, linking a perturbed intracellular calcium signaling and schizophrenia pathogenesis.

  8. DISC1 binds ITPR1 (show ITPR1 ELISA Kits) mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity.

  9. Disc1 variation leads to specific alterations in adult neurogenesis.

  10. The results of this study indicated that decreased D-serine production by astrocytic mutant DISC1 might lead to compensatory changes in levels of the amino acid transporters and NMDA receptors in the context of tripartite synapse.

Disrupted in Schizophrenia 1 (DISC1) Antigen Profile

Antigen Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with DISC1

  • disrupted in schizophrenia 1 (disc1) antibody
  • disrupted in schizophrenia 1 (DISC1) antibody
  • disrupted in schizophrenia 1 (Disc1) antibody
  • C1orf136 antibody
  • DISC1 antibody
  • SCZD9 antibody

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

GENE ID SPECIES
407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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