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Docking Protein 3 Proteins (DOK3)

DOK proteins are enzymatically inert adaptor or scaffolding proteins. Additionally we are shipping DOK3 Antibodies (94) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DOK3 79930 Q7L591
DOK3 27261 Q9QZK7
DOK3 306760 B2RYG7
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Top DOK3 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,188.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,243.17
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DOK3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)
,
Rat (Rattus)

More Proteins for Docking Protein 3 (DOK3) Interaction Partners

Human Docking Protein 3 (DOK3) interaction partners

  1. DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells.

  2. The Dok-3/Grb2 (show GRB2 Proteins) protein signal module attenuates Lyn (show LYN Proteins) kinase-dependent activation of Syk (show SYK Proteins) kinase in B cell antigen receptor microclusters

  3. absence of DOK3 increases LPS (show IRF6 Proteins) signaling, contributing to LPS (show IRF6 Proteins)-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions

  4. The novel platelet adapter Dok-3 is tyrosine phosphorylated in an Src kinase (show CSK Proteins)-independent manner downstream of alphaIIbbeta3 in human platelets, leading to an interaction with Grb2 (show GRB2 Proteins) and SHIP-1 (show INPP5D Proteins).

  5. findings indicate that Dok-3 sequesters Grb2 (show GRB2 Proteins) from Shc (show SHC1 Proteins) and inhibits the Ras-Erk (show EPHB2 Proteins) pathway downstream of PTKs

Mouse (Murine) Docking Protein 3 (DOK3) interaction partners

  1. we demonstrate that CpG treatment leads to ubiquitin-mediated degradation of DOK3 via interaction with an E3 ligase TNFR (show TNFRSF1A Proteins)-associated factor 6 (TRAF6 (show TRAF6 Proteins)).

  2. This study reveals DOK3 as a nonredundant regulator of plasma cell differentiation by up-regulating PD-1 (show PDCD1 Proteins) ligand expression through the attenuation of calcium signaling.

  3. Data show that docking protein 3 (DOK3) plays a role in TLR3 (show TLR3 Proteins) signaling by enabling TNFR (show TNFRSF1A Proteins)-associated factor (TRAF) 3 (show TRAF3 Proteins)/TANK-binding kinase (TBK) 1 (show TBK1 Proteins) binding and facilitating TBK1 (show TBK1 Proteins) and IFN regulatory factor 3 activation and the induction of IFN-beta (show IFNB1 Proteins) production.

  4. DOK3 physically associated with the ITAM of DAP12 (show TYROBP Proteins) through its phosphotyrosine-binding domain. In response to LPS (show TLR4 Proteins), DOK3 was phosphorylated in a DAP12 (show TYROBP Proteins)- and Src (show SRC Proteins)-dependent manner, which led to translocation of phosphorylated DOK3 to the plasma membrane.

  5. Triple Dok1 (show DOK1 Proteins) Doc2 (show DOC2A Proteins) Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.

  6. absence of DOK3 increases LPS (show TLR4 Proteins) signaling, contributing to LPS (show TLR4 Proteins)-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions

  7. identify a surprising but pivotal role for dynein and the microtubule network alongside Grb2 (show GRB2 Proteins), Dok-3, and Cbl (show CBL Proteins) in antigen gathering during B cell activation (show BLNK Proteins)

  8. Subcellular localization of Grb2 (show GRB2 Proteins) by the adaptor protein Dok-3 restricts the intensity of Ca2 (show CA2 Proteins)+ signaling in B cells.

  9. In the absence of Dok-3, the localization of the inhibitory phosphatase SHIP-1 (show INPP5D Proteins) to the plasma membrane is intact while its phosphorylation is compromised, suggesting that Dok-3 could function to facilitate or sustain the activation of SHIP-1 (show INPP5D Proteins).

DOK3 Protein Profile

Protein Summary

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Plays a role as negative regulator of the mobilization of calcium ions and of calcium signaling.

Gene names and symbols associated with Docking Protein 3 Proteins (DOK3)

  • docking protein 3 (DOK3)
  • docking protein 3 (Dok3)
  • AI450713 protein
  • DOK3 protein
  • Dokl protein

Protein level used designations for Docking Protein 3 Proteins (DOK3)

docking protein 3 , Dok-like protein , downstream of tyrosine kinase 3 , DOK-L , p62(dok)-like protein , p62Dok-like protein , Downstream of tyrosine kinase 3

GENE ID SPECIES
462309 Pan troglodytes
489087 Canis lupus familiaris
514894 Bos taurus
79930 Homo sapiens
27261 Mus musculus
306760 Rattus norvegicus
429960 Gallus gallus
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