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The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Additionally we are shipping DDC Kits (21) and DDC Proteins (21) and many more products for this protein.
Showing 10 out of 144 products:
Human Polyclonal DDC Primary Antibody for WB - ABIN374555
Voeller: Attention-deficit hyperactivity disorder (ADHD). in Journal of child neurology 2004
Cow (Bovine) Polyclonal DDC Primary Antibody for WB - ABIN372608
Berry, Juorio, Li, Boulton: Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. in Neurochemical research 1997
Cow (Bovine) Polyclonal DDC Primary Antibody for IHC, IHC (p) - ABIN152519
Blechingberg, Holm, Johansen, Børglum, Nielsen: Aromatic l-amino acid decarboxylase expression profiling and isoform detection in the developing porcine brain. in Brain research 2009
Human Polyclonal DDC Primary Antibody for IF (p), IHC (p) - ABIN725945
Hiramoto, Yamate, Kawanishi: Detection of Dopa-positive cells in mouse ovaries in response to ocular exposure to ultraviolet B rays. in Photodermatology, photoimmunology & photomedicine 2014
Cow (Bovine) Polyclonal DDC Primary Antibody for IHC, WB - ABIN2776802
Ma, Beuten, Payne, Dupont, Elston, Li: Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. in Human molecular genetics 2005
Human Polyclonal DDC Primary Antibody for WB - ABIN2776803
Giegling, Moreno-De-Luca, Rujescu, Schneider, Hartmann, Schnabel, Maurer, Möller, Serretti: Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008
Human Polyclonal DDC Primary Antibody for FACS, IF - ABIN651727
Treviño, Yang, French, Hunger, Carroll, Devidas, Willman, Neale, Downing, Raimondi, Pui, Evans, Relling: Germline genomic variants associated with childhood acute lymphoblastic leukemia. in Nature genetics 2009
epidermal Ddc induction at pupariation is under the control of an extended genomic region that contains both positive and negative regulatory elements
Broad-Complex protein is required for Ddc activation at eclosion in Drosophila
evidence for a wound response pathway that senses aseptic breaks in the barrier epidermis of Drosophila embryos; a minimal 472-bp Ddc wound response enhancer requires a Grh (show GNRH1 Antibodies) protein binding site and the function of the grh (show GNRH1 Antibodies) gene
The Ddc locus exhibits a complicated pattern of variation apparently due to several evolutionary forces.
The involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria.
Combinatorial expression of tyrosine hydroxylase (TH (show TH Antibodies)), aromatic acid acid decarboxylase (AADC), and the brain-specific (show CALY Antibodies) isoform of the vesicular monoamine transporter (show Slc18a2 Antibodies), VMAT2 (show Slc18a2 Antibodies).
Loss of Ddc appears to result in similar phenotypes as that of ADCC deficiency, thus zebrafish could be a good model for investigating pathogenetic mechanisms of AADC deficiency in children.
The data show that endothelial AADC plays an important role in cardiac synthesis of 5-HT and possibly in 5-HT-dependent regulation of nitric oxide generation.
Mash1 (show ASCL1 Antibodies) plays an important role in regulating the expression of AADC in type III cells in taste buds.
evidence for PKGIalpha-dependent phosphorylation and activation of neuronal AAAD (show AADAC Antibodies) in vitro, and introduce AAAD (show AADAC Antibodies) as a putative PKGIalpha substrate.
Data suggest a possible participation of aromatic L-amino acid decarboxylase (AADC) in the regulation of catecholamine biosynthesis in stellate ganglia of repeatedly stressed mice.
Results suggest that AADC expression begins at early stages of taste bud cell differentiation, and biogenic amines may act on taste bud differentiation of tongue epithelial cells, and further may regulate innervation of taste bud progenitor cells.
analysis of Ddc redefines the imprinted Grb10 (show GRB10 Antibodies) domain on mouse proximal chromosome 11 and identifies Ddc_exon1a as the first example of a heart-specific imprinted gene
the fact that renal DDC inversely correlated with renal sodium reabsorption suggest that renal and intestinal gender dimorphism in DDC could be related to sex-related differences in sodium balance observed between males and females
The results of this study showed that Lack of Association Between Polymorphisms in Dopa decarboxylase Genes With Childhood
The data showed that L-DOPA decarboxylase constitutes a highly promising molecular marker for renal cell carcinoma (show MOK Antibodies).
gene study of 987 BPD (show MOD(MDG4) Antibodies) cases and 1110 healthy controls found an association between BPD (show MOD(MDG4) Antibodies) [ borderline personality disorder ]and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene
Results revealed the general picture of structural and/or functional effects of each DDC mutation linked to AADC deficiency mutations and help to guide therapeutic decision and prevent inappropriate use of treatment regiments.
A novel homozygous DDC variant in syndromic intellectual disability patients, c.1123C>T, resulting in p.Arg375Cys missense substitution.
Results indicate that miR (show MLXIP Antibodies)-145 has the ability to regulate DDC mRNA expression and potentially this occurs by recognizing its mRNA as a target.
Our results suggest that DDC may be a genetic modifier of the l-dopa response in Parkinson's disease
assessed variants in four genes, DDC (rs3837091 and rs3735273), DRD2 (show DRD2 Antibodies) (rs1800496, rs1801028, and rs1799732), DRD4 (show DRD4 Antibodies) (rs4646984 and rs4646983), and COMT (show COMT Antibodies) (rs165599 and rs740603) in Indian ADHD subjects with comorbid attributes
8 SNPs in DDC gene showed significant associations with MaxDrinks.
Common allelic variants in the DDC gene may be involved in autism susceptibility.
The unusual oxygen-consuming oxidative deamination reaction catalyzed by the pyridoxal 5'-phosphate (PLP (show PLP1 Antibodies)) enzyme DOPA decarboxylase (DDC) was here investigated.
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, aromatic L-amino acid decarboxylase
, dopa decarboxylase
, dopamine decarboxylase
, transcription unit No. 3
, DHPAA synthase
, alpha methyl dopa
, alpha-methotrexate deficient
, alpha-methyl dopa resistant
, transcription unit No. 1
, dopa decarboxylase (aromatic L-amino acid decarboxylase)
, aromatic-L-amino-acid decarboxylase
, Aromatic-L-amino-acid decarboxylase
, aromatic-L-amino-acid decarboxylase-like
, aromatic-L-amino acid decarboxylase
, aromatic amino acid decarboxylase
, L-aromatic dopa decarboxylase
, L-Dopa decarboxylase