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DMRT1 is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). Additionally we are shipping DMRT1 Antibodies (64) and many more products for this protein.
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Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
Dmrt1 gene is not only associated with testis development, but also, may be important in ovary differentiation of zebrafish
The results suggest a role of changes in DMRT1 dosage in non-obstructive azoospermia potentially also through a process of gene misregulation, even though DMRT1 deleterious variants seem to be rare.
The role of DMT1 in mitochondrial iron acquisition by immunofluorescence with mitochondrial markers in cells and isolated mitochondria, as well as flow cytometric quantification of DMT1-positive mitochondria from an inducible expression system.
Point mutations of DMRT1 may be rarely associated with male infertility.
The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human spermatogenic failure
neither DMRT1 nor FGF9 abnormalities are frequently involved in dysgenetic male gonad development in patients with non-syndromic 46,XY disorder of sex development.
Meiosis signalling is dysregulated in carcinoma in situ (CIS (show CISH Proteins)) cells and that a key regulator of the mitosis-meiosis switch, DMRT1, is expressed in 'early-stage' CIS (show CISH Proteins) cells but is down-regulated with further invasive transformation.
The biological importance of the changes in expression of DMRT1 in Sertoli cells remains to be established, but it is consistent with DMRT1 reinforcing the inhibition of meiosis in the testis.
variants in or near BAK1 (show BAK1 Proteins), DMRT1, TERT (show TERT Proteins)-CLPTM1L (show CLPTM1L Proteins), and KITLG (show KITLG Proteins) predispose to familial and bilateral TGCT.
There is evidence that DMT1 expression and function respond rapidly to changes in dietary iron content
Chromosome 9p loss is the hallmark of squamous cell carcinoma, and DMRT1, DMRT3 (show DMRT3 Proteins) and DOCK8 genes at 9p24.3 might be of interest for the study of the pathophysiology of SCC (show CYP11A1 Proteins) as potential targets for therapeutic measures.
DMRT1 expression in the ovary silenced the female sex-maintenance gene Foxl2 (show FOXL2 Proteins) and reprogrammed juvenile and adult granulosa cells into Sertoli-like cells, triggering formation of structures resembling male seminiferous tubules.
Enforced expression of Dmrt1 in XX mouse fetal gonads using a Wt1 (show WT1 Proteins)-BAC transgene system is sufficient to drive testicular differentiation and male secondary sex development.
spontaneous SSC (show CYP11A1 Proteins) reprogramming is caused by unstable DNA methylation (show HELLS Proteins) and that a Dmrt1-Sox2 (show SOX2 Proteins) cascade is critical for regulating pluripotency in SSCs
DMRT1 controls pluripotency via transcriptional repression of Esrrb, Nr5a2/Lrh1 (show NR5A2 Proteins), and Sox2 (show SOX2 Proteins).
DMRT1 controls Stra8 sex-specifically, activating it in the fetal ovary and repressing it in the adult testis.
sexual fate is surprisingly labile in the testis: loss of the DMRT1 transcription factor in mouse Sertoli cells, even in adults, activates Foxl2 (show FOXL2 Proteins) and reprograms Sertoli cells into granulosa cells
These results suggest that novel ncRNA gene Dmr (show WDR20 Proteins) might play a negative regulatory role for Dmrt1 in male sexual development.
By coordinating spermatogonial development and mitotic amplification with meiosis, DMRT1 allows abundant, continuous production of sperm.
Data revealed that DMRT1 is a bifunctional transcriptional regulator, activating some genes and repressing others.
Conditional gene targeting indicates that Dmrt1 is required in fetal germ cells but not in Sertoli cells to prevent teratoma (show DND1 Proteins) formation.
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
doublesex- and mab-3-related transcription factor 1
, doublesex and mab-3 related transcription factor 1
, DM domain-containing transcription factor DMRT1
, DM domain expressed in testis 1
, DM domain expressed in testis protein 1