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Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A Proteins (DYRK1A)

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. Additionally we are shipping DYRK1A Antibodies (122) and DYRK1A Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DYRK1A 1859 Q13627
DYRK1A 13548 Q61214
Rat DYRK1A DYRK1A 25255 Q63470
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Top DYRK1A Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,486.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
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HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details

DYRK1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) Interaction Partners

Human Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. mutations in DYRK1A define a syndromic form of autism spectrum disorder and intellectual disability with neurodevelopmental defects consistent with murine and Drosophila knockout models

  2. Cyclin D1 (show CCND1 Proteins) Again Caught in the Act: Dyrk1a Links G1 and Neurogenesis in Down Syndrome.

  3. data indicate that host factor DYRK1A plays a role in the regulation of viral transcription and latency.

  4. Inhibition of DYRK1A and GSK3B induces human beta-cell proliferation

  5. A de novo splice site mutation and a de novo nonsense mutation in DYRK1A were identified in two patients with syndromic intellectual disability.

  6. RNA-seq evidence of biallelic expression of DYRK1A and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of DYRK1A is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB (show WRB Proteins) differentially methylated region (DMR (show WDR20 Proteins)) in disomic controls or trisomy (Down syndrome) individuals.

  7. Our report represents the largest cohort of individuals with DYRK1A disruptions to date, and is the first attempt to define consistent genotype-phenotype correlations among subjects with 21q22.13 microdeletions and DYRK1A SNVs or small INDELs.

  8. We identified unique truncating and non-synonymous mutations (three nonsense, four frameshift and two missense) in DYRK1A in nine patients and a large chromosomal deletion that encompassed DYRK1A in one patient

  9. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.

  10. novel mutations in DYRK1A contribute to the phenotype of the DYRK1A-associated developmental disorder

Mouse (Murine) Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. study identifies DYRK1A-STAT (show STAT1 Proteins) as a signaling pathway responsible for the differentiation of neural progenitors into astrocytes, with direct implication for the anomalies in brain development observed in Down syndrome

  2. This study identified decreased neuronal firing rate and deficits in gamma frequency in the prefrontal cortices of transgenic mice overexpressing Dyrk1A.

  3. Increased Dyrk1a gene dosage is a major contributing factor to the abnormal appendicular skeletal phenotype observed in adolescent Ts65Dn Down syndrome mice.

  4. the increased immunostaining of DYRK1A in HIV+ brains without pathology points at dysregulation of DYRK1A as an early event in the neuronal complications of HIV infection.

  5. Our results identify DYRK1A as a physiologically relevant regulator of Treg cell differentiation and suggest a broader role for other DYRK family members in immune homeostasis.

  6. these data suggest that the dosage imbalance of genes other than Dyrk1a is involved in the development of the prenatal bone phenotype in Ts65Dn embryos.

  7. Show the crucial role of the DYRK1A pathway in the regulation of beta cell mass and carbohydrate metabolism in vivo. Activating the DYRK1A pathway could thus represent an innovative way to increase functional beta cell mass.

  8. DYRK1A has a role in lymphopoiesis; Cyclin D3 (show CCND3 Proteins) protein stability is negatively regulated during exit from the proliferative phases of B and T cell development

  9. Dyrk1A has a role in phosphorylation and inactivation of GSK3beta

  10. Study shows that DYRK1A overexpression affects pathways involved in synaptogenesis and synaptic plasticity and influences excitation/inhibition balance toward inhibition

Xenopus laevis Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) interaction partners

  1. Dyrk1A positively and selectively modulates p120-catenin (show CTNND1 Proteins) protein levels, thus having an impact on p120-catenin (show CTNND1 Proteins) and Kaiso (show ZBTB33 Proteins) (and canonical Wnt (show WNT2 Proteins)) gene targets such as siamois and wnt11.

DYRK1A Protein Profile

Protein Summary

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Gene names and symbols associated with DYRK1A

  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A)
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (dyrk1a)
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a)
  • dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1a)
  • 2310043O08Rik protein
  • D16Ertd272e protein
  • D16Ertd493e protein
  • Dyrk protein
  • DYRK1 protein
  • DYRK1A protein
  • ENSMUSG00000074897 protein
  • Gm10783 protein
  • HP86 protein
  • mmb protein
  • MNB protein
  • Mnbh protein
  • Mp86 protein
  • MRD7 protein
  • PSK47 protein

Protein level used designations for DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A , dual specificity tyrosine-phosphorylation-regulated kinase 1A , minibrain , protein kinase minibrain homolog , dual specificity tyrosine-phosphorylation-regulated kinase 1A-like , MNB/DYRK protein kinase , dual specificity YAK1-related kinase , hMNB , mnb protein kinase homolog hp86 , serine/threonine kinase MNB , serine/threonine-specific protein kinase , Dual Specificity Yak1-related kinase , MNBH , RP86 , minibrain protein kinase , Protein kinase minibrain homolog

GENE ID SPECIES
100051707 Equus caballus
458545 Pan troglodytes
693812 Macaca mulatta
779733 Xenopus (Silurana) tropicalis
100019775 Monodelphis domestica
100078677 Ornithorhynchus anatinus
100389032 Callithrix jacchus
100479774 Ailuropoda melanoleuca
100562279 Anolis carolinensis
100601498 Nomascus leucogenys
1859 Homo sapiens
13548 Mus musculus
25255 Rattus norvegicus
100350296 Oryctolagus cuniculus
395233 Gallus gallus
100514684 Sus scrofa
446302 Xenopus laevis
487755 Canis lupus familiaris
532989 Bos taurus
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