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Dystrobrevin Binding Protein 1 Proteins (DTNBP1)

DTNBP1 encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Additionally we are shipping Dystrobrevin Binding Protein 1 Antibodies (115) and Dystrobrevin Binding Protein 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DTNBP1 84062 Q96EV8
DTNBP1 94245 Q91WZ8
DTNBP1 641528 Q5M834
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Top Dystrobrevin Binding Protein 1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,959.00
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$4,009.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$467.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

DTNBP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Dystrobrevin Binding Protein 1 Proteins

  1. Human DTNBP1 Protein expressed in Escherichia coli (E. coli) - ABIN667731 : Chen, Feng, Hao, Guo, He, Zhou, Guo, Huang, Xiong, Zheng, Zuo, Zhang, Li, Zhou: DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. in The Journal of cell biology 2008 (PubMed)
    Show all 2 references for ABIN667731

More Proteins for Dystrobrevin Binding Protein 1 (DTNBP1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Dystrobrevin Binding Protein 1 (DTNBP1) interaction partners

  1. Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess (show RCC1 Proteins) is a neurotoxin and whose depletion constitutes a micronutrient deficiency.

  2. Loss-of-function alleles of dysbindin or Blos1 (show BLOC1S1 Proteins) impaired neurotransmitter release and synaptic function and plasticity.

  3. optimal binding ratio between Dysb and Ebony might contribute to such non-linear effects. Thus, Ddysb-dependent regulation of Ebony could be one of the mechanisms that mediate dopamine signal

  4. study found that dysbindin (CG6856) is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx

Human Dystrobrevin Binding Protein 1 (DTNBP1) interaction partners

  1. Authors report the examination of DNA methylation status of DTNBP1 promoter region, one of the most credible candidate genes affected in SCZ.

  2. DTNBP1 is likely to play a role in development of auditory related, visual and olfactory hallucinations

  3. dysbindin-1A protein levels are highly regulated in the nucleus and that dysbindin-1A regulates transcription factor NF-kappa B (show NFKB1 Proteins) activity to promote the expression of MMP-9 (show MMP9 Proteins) and TNF-alpha (show TNF Proteins)

  4. Study demonstrated that dysbindin-1B, rather than dysbindin-1A and dysbindin-1C, has the ability to aggregate

  5. The present findings intransgenic mice expressing human DTNBP1 support the role of dysbindin-1 in psychiatric disorders.

  6. Findings add further evidence suggesting an association between dysbindin gene variability and cognitive abnormalities in schizophrenia.

  7. dysbindin-1 formed a protein complex with HDAC3 (show HDAC3 Proteins) in human neuroblastoma (show ARHGEF16 Proteins) cells

  8. DISC1 forms a complex with dysbindin and increases its sta (show DISC1 Proteins)bility in association with a reduction in ubiquitylation.

  9. In homozygotes and heterozygotes of risk allele (CC) of DTNBP1, there was a trend to volumetric reductions in brain regions, regardless of schizophrenia diagnosis.

  10. loss of function mutations in the genes encoding dysbindin and its interacting BLOC-1 (show BLOC1S1 Proteins) subunits

Mouse (Murine) Dystrobrevin Binding Protein 1 (DTNBP1) interaction partners

  1. Dysbindin-1 modulates thus D2 and D3 receptor (show DRD3 Proteins) signaling, supporting a link to schizophrenia

  2. Results indicate that perturbations downstream of DTNBP1, confer susceptibility to copper, a metal that in excess (show RCC1 Proteins) is a neurotoxin and whose depletion constitutes a micronutrient deficiency.

  3. Results suggest that Dtnbp1 deficiency may lead to increased vulnerability to schizophrenia under environmental conditions where circadian rhythms are altered

  4. Snapin-dysbindin interaction regulates synaptic vesicle positional priming through BLOC-1/AP-3-dependent sorting.

  5. Dysbindin has three isoforms associating with different complexes in the P2 fraction of mouse brain.

  6. Dysbindin-1C deficiency causes impaired autophagy, which is likely implicated in the pathogenesis of schizophrenia.

  7. The neurite outgrowth defect induced by knockdown of DISC1 (show DISC1 Proteins) was partially reversed by coexpression of dysbindin.

  8. dysbindin-1C, rather than dysbindin-1A, regulates adult hippocampal neurogenesis in a non-cell autonomous manner

  9. loss of function mutations in the genes encoding dysbindin and its interacting BLOC-1 (show PLDN Proteins) subunits

  10. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT (show COMT Proteins) and DTNBP1.

Dystrobrevin Binding Protein 1 (DTNBP1) Protein Profile

Protein Summary

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with DTNBP1

  • dystrobrevin binding protein 1 (DTNBP1)
  • dysbindin (dysb)
  • Dysbindin (dtbp1)
  • dystrobrevin binding protein 1a (dtnbp1a)
  • dystrobrevin binding protein 1 (dtnbp1)
  • dystrobrevin binding protein 1 (Dtnbp1)
  • 5430437B18Rik protein
  • AW048963 protein
  • Bloc1s8 protein
  • CG6856 protein
  • DBND protein
  • Ddysb protein
  • Dmel\\CG6856 protein
  • DTNBP1 protein
  • dysbindin protein
  • HPS7 protein
  • MGC83903 protein
  • MGC85477 protein
  • My031 protein
  • sdy protein
  • zgc:56462 protein

Protein level used designations for DTNBP1

dysbindin , CG6856-PA , CG6856-PB , dysb-PA , dysb-PB , Dysbindin , BLOC-1 subunit 8-A , biogenesis of lysosome-related organelles complex 1 subunit 8-A , dysbindin-A , dystrobrevin binding protein 1 , dystrobrevin-binding protein 1-A , BLOC-1 subunit 8 , Hermansky-Pudlak syndrome 7 protein , biogenesis of lysosomal organelles complex-1, subunit 8 , biogenesis of lysosome-related organelles complex 1 subunit 8 , dysbindin-1 , HPS7 protein homolog , dystrobrevin-binding protein 1 , hermansky-Pudlak syndrome 7 protein homolog , sandy , distrobrevin binding protein 1

GENE ID SPECIES
100145862 Ovis aries
40052 Drosophila melanogaster
100195576 Salmo salar
394109 Danio rerio
446421 Xenopus laevis
447615 Xenopus laevis
747324 Pan troglodytes
100216117 Xenopus (Silurana) tropicalis
84062 Homo sapiens
94245 Mus musculus
420840 Gallus gallus
100049697 Sus scrofa
506612 Bos taurus
641528 Rattus norvegicus
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