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Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Additionally we are shipping EF-Hand Calcium Binding Domain 4B Proteins (4) and many more products for this protein.
Showing 10 out of 46 products:
Human Polyclonal EFCAB4B Primary Antibody for EIA, WB - ABIN783785
Srikanth, Jung, Kim, Souda, Whitelegge, Gwack: A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. in Nature cell biology 2010
Show all 2 references for ABIN783785
Human Polyclonal EFCAB4B Primary Antibody for WB - ABIN2783361
Lim, Hao, Shaw, Patel, Szabó, Rual, Fisk, Li, Smolyar, Hill, Barabási, Vidal, Zoghbi: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. in Cell 2006
endothelial cells contain a long variant of CRACR2A which is an EF-hand-containing Rab (show HRB Antibodies) protein that lacks impact on CRAC channels
CRACR2A interacts directly with Orai1 (show ORAI1 Antibodies) and STIM1 (show STIM1 Antibodies), forming a ternary complex that dissociates at elevated Ca(2 (show CA2 Antibodies)+) concentrations; is a key regulator of CRAC channel-mediated SOCE
Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity).
CRAC channel regulator 2A
, EF-hand calcium-binding domain-containing protein 4B
, calcium release-activated calcium channel regulator 2A