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May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). Additionally we are shipping EML4 Proteins (4) and many more products for this protein.
Showing 10 out of 30 products:
Human Polyclonal EML4 Primary Antibody for ICC, IF - ABIN4307859
Preusser, Berghoff, Ilhan-Mutlu, Magerle, Dinhof, Widhalm, Dieckmann, Marosi, Wöhrer, Hackl, Zöchbauer-Müller, von Deimling, Schoppmann, Zielinski, Streubel, Birner: ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer. in Lung cancer (Amsterdam, Netherlands) 2013
Show all 3 references for ABIN4307859
Human Monoclonal EML4 Primary Antibody for IHC (p), ELISA - ABIN565390
Radtke, Rezaie, Kugler, Zabel, Schultz, Vollmer, Goldmann, Lang: Expression analysis of EML4 in normal lung tissue and non-small cell lung cancer (NSCLC) in the absence and presence of chemotherapeutics. in Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2010
Data show that inhibition of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK (show ALK Antibodies))-mediated stem-like properties enhances the anti-tumor effect.
This review describes the biology of EML4 and ALK (show ALK Antibodies), explains the main features of EML4-ALK (show ALK Antibodies) fusion proteins and outline the therapies that target EML4-ALK (show ALK Antibodies) in cancer. [review]
We further showed that both EML4-ALK (show ALK Antibodies) and mutant forms of EGFR (show EGFR Antibodies) modulate PD-L1 (show CD274 Antibodies) expression via common downstream pathways mediated by MEK (show MAP2K1 Antibodies)-ERK (show EPHB2 Antibodies) and by PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies).
EGFR (show EGFR Antibodies) gene mutations and the EML4-ALK (show ALK Antibodies) fusion gene were detected in 92 lung adenocarcinoma patients in China.
In the absence of EML4, NUDC was no longer able to localize to the mitotic spindle, whereas NUDC was dispensable for EML4 localization.
It was revealed that the EML4-ALK (show ALK Antibodies) fusion gene was observed predominantly in adenocarcinoma, non-smoking and non-small-cell lung cancers (NSCLC) patients, especially those diagnosed in the advanced clinical stage of NSCLC.
Results suggested that chromothripsis may be a mechanism of oncogenic rearrangement of EML4-ALK (show ALK Antibodies).
The FISH-based method of detecting EML4-ALK (show ALK Antibodies) rearrangement in lung cancer may miss a significant number of patients who could benefit from targeted ALK (show ALK Antibodies) therapy. IHC should be strongly considered, and NGS is recommended in borderline cases.
H1299 NSCLC cells stably expressing EML4-ALK (show ALK Antibodies) acquire epithelial-mesenchymal transition (EMT (show ITK Antibodies)) phenotype, associated with enhanced invasive migration and increased expression of EMT (show ITK Antibodies)-inducing transcription factors.
We have determined crystal structures of the coiled-coils from EML2 (show EML2 Antibodies) and EML4, which describe the structural basis of both EML self-association and oncogenic EML4-ALK (show ALK Antibodies) activation.
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).
echinoderm microtubule-associated protein-like 4
, echinoderm microtubule associated protein like 4
, echinoderm microtubule-associated protein-like 4-like
, restrictedly overexpressed proliferation-associated protein
, ropp 120