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Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Additionally we are shipping and many more products for this protein.
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Human Polyclonal EFTUD1 Primary Antibody for EIA, IHC (p) - ABIN952035
Nicolas, Poitelon, Chouery, Salem, Levy, Mégarbané, Delague: CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592. in European journal of human genetics : EJHG 2010
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Upon EFL1 (show EFNA1 Antibodies) binding, SBDS (show SBDS Antibodies) is repositioned around helix 69, thus facilitating a conformational switch in EFL1 (show EFNA1 Antibodies) that displaces eIF6 (show EIF6 Antibodies) by competing for an overlapping binding site on the 60S ribosomal subunit.
Downregulation of EFTUD1 induced cell-cycle arrest and apoptosis in gliomas by impairing ribosome biogenesis
Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits.
elongation factor Tu GTP-binding domain-containing protein 1
, elongation factor-like 1
, ribosome assembly 1 homolog