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Endothelin Receptor Type A Proteins (EDNRA)

EDNRA encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. Additionally we are shipping Endothelin-1 Receptor Antibodies (74) and Endothelin-1 Receptor Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EDNRA 1909 P25101
Rat EDNRA EDNRA 24326 P26684
EDNRA 13617 Q61614
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Top Endothelin-1 Receptor Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Staphylococcus aureus His tag 50 μg Log in to see 21 to 26 Days
$341.00
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Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

EDNRA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Endothelin Receptor Type A (EDNRA) Interaction Partners

Horse (Equine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR antagonists might be beneficial for treatment of laminitis in horses.

  2. both endothelin A and endothelin B receptors are involved in the net tonic response to ET-1 (show EDN1 Proteins) in normal laminar veins.

Zebrafish Endothelin Receptor Type A (EDNRA) interaction partners

  1. Data suggest that edn1 (show EDN1 Proteins)/ednraa (endothelin-1/endothelin-1 (show EDN1 Proteins) receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.

  2. Edn1 (show EDN1 Proteins) from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest.

Xenopus laevis Endothelin Receptor Type A (EDNRA) interaction partners

  1. A new role for ednra signaling during early neural crest specification is reported.

Human Endothelin Receptor Type A (EDNRA) interaction partners

  1. Data show that macitentan interferes with the profibrotic action of transforming growth factor-beta (TGF-beta), blocking the endothelin receptor type A (ET-1 (show EDN1 Proteins) receptor) portion of the ET-1 (show EDN1 Proteins)/TGF-beta (show TGFB1 Proteins) receptor complex.

  2. Ednra, encoding Endothelin receptor A (ETA)-the target of Endothelin 1 (ET-1 (show EDN1 Proteins))-was significantly increased in Systemic Capillary Leak Syndrome blood-outgrowth endothelial cells compared to healthy controls.

  3. role of ET-1 (show EDN1 Proteins)/ETR-A signalling in Gd-induced fibrosis and calcification in nephrogenic systemic fibrosis

  4. Plasma proET-1 levels increase in CKD and may be useful biomarkers of renal injury. Increases in response to endothelin A antagonism may reflect EDN1 (show EDN1 Proteins) upregulation, which may partly explain fluid retention with these agents.

  5. Genebased analyses revealed associations of the EDNRA gene with longitudinal Blood Pressure phenotypes, associations with essential hypertension, Blood Pressure salt sensitivity, preeclampsia, or preclinical stages of atherosclerosis.

  6. Endothelin receptor A was detected in all patients with squamous cell carcinoma and psoriasis, with a higher frequency and grade of expression than controls and basal cell carcinoma.

  7. The aim was to quantify the density of ETA and ETB (show EDNRB Proteins) receptors in cardiopulmonary tissue from pulmonary arterial hypertension patients and the monocrotaline (MCT (show MCAT Proteins)) rat.

  8. effect of SNP polymorphisms of EDN1 (show EDN1 Proteins), EDNRA, and EDNRB (show EDNRB Proteins) gene on ischemic stroke

  9. findings suggest a role for agonistic autoantibodies-induced activation of immune cells mediated by the AT1R (show AGTR1 Proteins) and the ETAR in the pathogenesis or even the onset of systemic sclerosis

  10. These results indicate a novel function for Galphas (show GNAS Proteins) signaling in ET-1 (show EDN1 Proteins)/ETAR-mediated ovarian cancer oncogenesis.

Mouse (Murine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. IFN-gamma (show IFNG Proteins) regulates hypertensive vascular collagen remodeling induced by ANG II (show AGT Proteins) and inhibits the differentiation of Th17 cells by suppressing OPN (show SPP1 Proteins) expression and regulating secretion of inflammatory cytokines.

  2. results indicate that autocrine OPN (show SPP1 Proteins) plays a crucial role in HPC expansion, migration, and subsequent oncogenic transformation of HPCs, which may provide a new insight into hepatocarcinogenesis

  3. OPN (show SPP1 Proteins) produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke

  4. ETAR-positive macrophages highly accumulated in the inflamed liver of mutant p53 (show TP53 Proteins)(R172) plus IL27RA (show IL27RA Proteins)(-/-)

  5. During the priming phase of liver regeneration, osteopontin (show SPP1 Proteins) enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Proteins) release and the downstream activation of Stat3 (show STAT3 Proteins).

  6. OPN (show SPP1 Proteins) deficiency accelerated the spontaneous development of colitis in mice with disrupted gut (show GUSB Proteins) microbiota and macrophage phagocytic activity.

  7. mechanical stretch (MS) directly increased OPN (show SPP1 Proteins) protein expression and secretion in vascular smooth muscle cells.

  8. OPN (show SPP1 Proteins) may modulate psoriasis-like inflammation through altering lymphocyte distribution in skin and draining lymph nodes and by inducing IL-17 (show IL17A Proteins) expression of inflammatory T cells.

  9. Osteopontin (show SPP1 Proteins) is expressed in the oviduct and promotes fertilization and preimplantation embryo development.

  10. BSP (show KLK6 Proteins) has a role in mouse cementum and craniofacial bone mineralization

Pig (Porcine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. PDE5 (show PDE5A Proteins) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB (show EDNRB Proteins) receptor blockade in the presence of PDE5 (show PDE5A Proteins) inhibition.

  3. Blocking ET(A) and ET(B (show EDNRB Proteins)) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high intra-abdominal pressure (IAP (show CD47 Proteins)).

  4. Anti-endothelin receptor A therapy accelerated the reversal of flow-induced pulmonary arterial disease after flow correction.

  5. study suggests a possible role for endothelin-1 (show EDN1 Proteins)(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Proteins)) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig

  6. Endothelin-A receptor antagonist alters the expression of vasoactive genes and proinflammatory cytokines during hepatic ischemic/reperfusion.

  7. Report that inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury improved gas exchange and hemodynamics.

  8. ET(A) blockade had no effect on pulmonary vascular resistance at rest or during exercise.

  9. PKC (show FYN Proteins) and MAPK (show MAPK1 Proteins) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries

Cow (Bovine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.

  2. Elevated local expression of ET-1 (show EDN1 Proteins) and Ednra/Ednrb (show EDNRB Proteins) during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.

Endothelin-1 Receptor (EDNRA) Protein Profile

Protein Summary

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with EDNRA

  • endothelin receptor type A (EDNRA)
  • endothelin receptor type Aa (ednraa)
  • endothelin receptor type A (ednra-a)
  • endothelin receptor type A (ednra)
  • endothelin receptor type A (etr)
  • endothelin receptor type A (Ednra)
  • secreted phosphoprotein 1 (Spp1)
  • 2AR protein
  • Apl-1 protein
  • BNSP protein
  • Bsp protein
  • BSPI protein
  • ednr-a protein
  • ednra protein
  • ednraa protein
  • Endor protein
  • ET-A protein
  • ET-AR protein
  • ETa protein
  • ETA-1 protein
  • ETA-R protein
  • ETAR protein
  • ETRA protein
  • Gpcr10 protein
  • hET-AR protein
  • OP protein
  • Opn protein
  • Opnl protein
  • RGD1559432 protein
  • Ric protein
  • Spp-1 protein
  • wu:fb75g12 protein

Protein level used designations for EDNRA

endothelin-1 receptor , Ednra2 , endothelin receptor A , endothelin receptor type A , endothelin type-A receptor 2 , etID40953.1 , Endothelin-1 receptor type A , endothelin receptor type A a , G protein-coupled receptor , endothelin receptor subtype A , endothelin-1-specific receptor , endothelin A receptor , ET-A , G-protein coupled receptor 10 , ET-AR , 44 kDa bone phosphoprotein , bone sialoprotein 1 , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin , osteopontin-like protein

GENE ID SPECIES
100062644 Equus caballus
114550 Danio rerio
380342 Xenopus laevis
779728 Xenopus (Silurana) tropicalis
100049646 Takifugu rubripes
1909 Homo sapiens
24326 Rattus norvegicus
13617 Mus musculus
373908 Gallus gallus
450187 Canis lupus familiaris
397457 Sus scrofa
281749 Bos taurus
443465 Ovis aries
20750 Mus musculus
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