Epithelial Cell Adhesion Molecule Proteins (EPCAM)

EPCAM encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. Additionally we are shipping EPCAM Antibodies (1090) and EPCAM Kits (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EPCAM 924 P09564
EPCAM 17075 Q99JW5
EPCAM 171577 O55159
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Top EPCAM Proteins at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag Human EpCAM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_HEK-293 Cells Mouse His tag Mouse EpCAM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%. 100 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_HEK-293 Cells Rhesus Monkey His tag Rhesus macaque EpCAM, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
$308.00
Details
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Cynomolgus His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details

EPCAM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
, , , , , , , , , ,
Mouse (Murine) , , ,
,
Rat (Rattus) ,
,

Top referenced EPCAM Proteins

  1. Human EPCAM Protein expressed in Human Cells - ABIN2003245 : Simon, Podolsky, Moldenhauer, Isselbacher, Gattoni-Celli, Brand: Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 6 references for 2003245

  2. Cynomolgus EPCAM Protein expressed in Human Cells - ABIN2010117 : Chong, Speicher: Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM). in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for 2010117

  3. Mouse (Murine) EPCAM Protein expressed in Human Cells - ABIN2008019 : Litvinov, Velders, Bakker, Fleuren, Warnaar: Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. in The Journal of cell biology 1994 (PubMed)
    Show all 5 references for 2008019

  4. Rat (Rattus) EPCAM Protein expressed in Human Cells - ABIN2009454 : Balzar, Winter, de Boer, Litvinov: The biology of the 17-1A antigen (Ep-CAM). in Journal of molecular medicine (Berlin, Germany) 2000 (PubMed)
    Show all 4 references for 2009454

  5. Human EPCAM Protein expressed in Escherichia coli (E. coli) - ABIN1098717 : Münz, Zeidler, Gires: The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. in Cancer letters 2005 (PubMed)
    Show all 2 references for 1098717

  6. Human EPCAM Protein expressed in HEK-293 Cells - ABIN2181014 : Zielonka, Weber, Becker, Doerner, Christmann, Christmann, Uth, Fritz, Schäfer, Steinmann, Empting, Ockelmann, Lierz, Kolmar: Shark Attack: high affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation. in Journal of biotechnology 2014 (PubMed)

  7. Rhesus Monkey EPCAM Protein expressed in HEK-293 Cells - ABIN2181021 : Akita, Nagano, Takeda, Eguchi, Wada, Kobayashi, Marubashi, Tanemura, Takahashi, Ohigashi, Tomita, Ishikawa, Mori, Doki: Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity. in Oncogene 2011 (PubMed)

More Proteins for Epithelial Cell Adhesion Molecule (EPCAM) Interaction Partners

Zebrafish Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. Gene ontology analysis revealed that EpCAM controls various developmental programs, including uretric bud development, morphogenesis of branching epithelium, regulation of cell differentiation and cilium morphogenesis.

  2. EpCAM acts as a partner of E-cadherin (show CDH1 Proteins) to control adhesiveness and integrity as well as plasticity and morphogenesis within simple epithelia

Xenopus laevis Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. identification of EpCAM in a gain-of-function screen for inducers of abnormal tissue mixing during gastrulation

Human Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. These results identify EpCAM as a substrate of matriptase (show ST14 Proteins) and link HAI-2 (show SPINT2 Proteins), matriptase (show ST14 Proteins), EpCAM, and claudin-7 (show CLDN7 Proteins) in a functionally important pathway that causes disease when it is dysregulated.

  2. The EpCAM aptamer conjugated NCS showed specificity to EpCAM-positive cells.

  3. Pseudomyxoma peritonei ubiquitously express CEA (show CEACAM5 Proteins) and EpCAM.

  4. relationship between EpCAM-regulated transcription and altered biophysical properties of cells that promoteepithelial-mesenchymal transition (EMT (show ITK Proteins)) in advanced endometrial cancer.

  5. used a next generation sequencing (NGS) approach. NY-SAR-35 expression induced growth, proliferation, metastasis, and stemness genes, as indicated by the up-regulations of CXCR4 (show CXCR4 Proteins), EpCAM, CD133, and CD44 (show CD44 Proteins), at the mRNA and protein levels

  6. These results indicate that adipocyte-secreted factors might regulate cancer stem cell behavior through several signaling molecules including c-Met, STAT3 and ERK1/2 and inhibition of these signaling pathways offer novel strategies in targeting the effect of adipose-derived cytokines in cancer.

  7. The meta-analysis demonstrated that the expression of EpCAM in the gastric cancer group was greater than that in the control group. Moreover, EpCAM overexpression was associated with larger tumour size, lymphnode metastasis and worse prognosis in gastric cancer. [review]

  8. expression of EpCAM(MT) is associated with a more aggressive phenotype and predicts poor survival in patients with colorectal cancer.

  9. Higher levels of epithelial cell adhesion molecule (EpCAM) in breast cancer may be associated with poor response to Neoadjuvant chemotherapy (NAC) via a potential chemoresistant effect.

  10. By monitoring the change of fluorescence signal, the target EpCAM protein could be detected sensitively and selectively with a linear detection range from 3nM to 54nM and limit of detection (LOD) around 450pM. In addition, this nanobiosensor has been successfully used for EpCAM-expressed breast cancer MCF-7 cell detection

Mouse (Murine) Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. These results identify EpCAM as a substrate of matriptase (show ST14 Proteins) and link HAI-2 (show SPINT2 Proteins), matriptase (show ST14 Proteins), EpCAM, and claudin-7 (show CLDN7 Proteins) in a functionally important pathway that causes disease when it is dysregulated.

  2. EpCAM appears to differentially regulate Langerhans cell mobility/migration in the setting of limited inflammation as compared with the intense inflammation triggered by contact sensitizers

  3. Knock-down EpCAM cell model of congenital tufting enteropathy was developed. In vivo inducible mouse model was developed resulting in mutant EpCAM protein.

  4. in addition to converting to cholangiocyte-like cells, Sox9 (show SOX9 Proteins)(+)EpCAM(-) cells provide luminal space near expanded ductular structures to prevent deterioration of the injuries and potentially supply new hepatocytes to repair damaged tissues

  5. EpCAM is a highly conserved protein present in fishes, amphibians, reptiles, birds, marsupials, and placental mammals, and is subject to shedding, gamma-secretase-dependent regulated intramembrane proteolysis, and proteasome-mediated degradation.

  6. Suggest pivotal role of EpCAM in intestinal epithelial structure and integrity, with mutations resulting in congenital tufting enteropathy.

  7. mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin (show CDH1 Proteins)/beta-catenin (show CTNNB1 Proteins).

  8. EpCAM contributes to formation of intestinal barrier by recruiting claudins to cell-cell junctions.

  9. These results conclusively link EpCAM expression to Langerhan cell (LC) motility/migration and LC migration to immune regulation.

  10. Results show that SSCs are the most concentrated in CD9 (show CD9 Proteins)(+)EPCAM(low/-) population and also suggest that EPCAM plays an important role in progenitor cell amplification in the mouse spermatogenic system.

Pig (Porcine) Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. Ep-CAM may act as a physical homophilic interaction molecule between IELs and IECs at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection [Ep-CAM]

EPCAM Protein Profile

Protein Summary

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Gene names and symbols associated with EPCAM

  • epithelial cell adhesion molecule (epcam)
  • epithelial cell adhesion molecule (EPCAM)
  • zgc:110304 (zgc:110304)
  • epithelial cell adhesion molecule (LOC100229650)
  • CD7 molecule (CD7)
  • epithelial cell adhesion molecule (Epcam)
  • CD326 protein
  • co17-1a protein
  • DIAR5 protein
  • EGP protein
  • EGP-2 protein
  • EGP40 protein
  • Egp314 protein
  • Ep-CAM protein
  • EPCAM protein
  • EpCAM1 protein
  • ESA protein
  • GA733-2 protein
  • gp40 protein
  • hegp-2 protein
  • HNPCC8 protein
  • KS1/4 protein
  • KSA protein
  • LEU-9 protein
  • Ly74 protein
  • M4S1 protein
  • MGC80540 protein
  • MIC18 protein
  • MK-1 protein
  • sb:cb6 protein
  • Tacsd1 protein
  • tacstd protein
  • Tacstd1 protein
  • Tp40 protein
  • TP41 protein
  • TROP1 protein
  • wu:fj17g02 protein
  • zgc:77119 protein
  • zgc:110304 protein

Protein level used designations for EPCAM

pan-epithelial glycoprotein , tumor-associated calcium signal transducer , epithelial cell adhesion molecule , tumor-associated calcium signal transducer 1 , CD7 antigen (p41) , T-cell antigen CD7 , T-cell leukemia antigen , T-cell surface antigen Leu-9 , p41 protein , adenocarcinoma-associated antigen , cell surface glycoprotein Trop-1 , epithelial glycoprotein 314 , human epithelial glycoprotein-2 , major gastrointestinal tumor-associated protein GA733-2 , membrane component, chromosome 4, surface marker (35kD glycoprotein) , Trop-1 protein , lymphocyte antigen 74 , mEGP314 , panepithelial glycoprotein 314 , protein 289A , ep-CAM , epithelial glycoprotein

GENE ID SPECIES
406454 Danio rerio
446810 Xenopus laevis
459214 Pan troglodytes
550255 Danio rerio
100229650 Taeniopygia guttata
100302339 Ovis aries
496567 Xenopus (Silurana) tropicalis
924 Homo sapiens
4072 Homo sapiens
17075 Mus musculus
171577 Rattus norvegicus
481360 Canis lupus familiaris
403163 Sus scrofa
514039 Bos taurus
421292 Gallus gallus
677680 Macaca mulatta
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