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Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (By similarity).. Additionally we are shipping ETV2 Antibodies (54) and many more products for this protein.
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Data have identified the Xenopus ortholog of er71 and could show that er71 function in Xenopus is required for vasculogenesis, but not for the development of hematopoietic cells.
An essential role for ETV2 in endothelial development.
results suggest that the LSD1 (show KDM1A Proteins)-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
Etv2 alone is required for early vasculogenesis, whereas Etv2 and Fli1b function redundantly during late vasculogenesis and early embryonic angiogenesis.
The results identify an etv2 cis (show CISH Proteins)-regulatory mechanism controlling cardiovascular fate choice implying that etv2 participates in a transcriptional network mediating developmental plasticity of endothelial progenitor cells during embryonic development.
etv2 has a critical cell autonomous requirement during neutropoiesis in the anterior lateral plate mesoderm.
etv2 acts during early development to specify endothelial lineages and is then down-regulated, in part through post-transcriptional repression by microRNAs, to allow normal vascular development.
Expression of Etv2 alone is sufficient to transdifferentiate fast skeletal muscle into functional endothelial cells in vivo.
substantially increased number of candidate genes regulated by etsrp in vascular cells
Identify mesodermal foxc1a/b as a direct upstream regulator of etsrp in angioblasts. This establishes a new molecular link in the process of mesoderm specification into angioblast.
These results argue that Etsrp initiates endothelial and endocardial, and inhibits myocardial, differentiation by two distinct mechanisms.
Fli (show FLI1 Proteins)+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
ets variant 2 (ETV2) alone directly converts primary human adult skin fibroblasts into functional vascular endothelial cells.
identify human Etv2/ER71 and mouse ER71 proteins as functional orthologs of Etsrp (show ETS1 Proteins)
Etv2 transactivates miR (show MLXIP Proteins)-130a in the endothelial progenitors.
Endothelial ETV2 is required for postnatal vascular repair and regeneration.
studies define upstream and downstream networks that serve as a transcriptional rheostat to regulate Etv2 gene expression
These findings highlight the critical role that transient ETV2 expression plays in the regulation of hematopoietic and endothelial cell lineage specification and stability.
Data indicate that transcription factor Mesp1 (show MESP1 Proteins) interacts physically with cAMP-responsive element binding protein 1 (Creb1 (show CREB1 Proteins)) and transcriptionally regulates Ets variant 2 (Etv2) gene expression.
ETV2 directly regulates Sox7 (show SOX7 Proteins), and ETV2 governs endothelial development by regulating transcriptional networks which include Sox7 (show SOX7 Proteins).
We show that ER71 directly interacts with OVOL2 (show OVOL2 Proteins) and that such interaction is critical for FLK1 (show KDR Proteins)(+) cell generation and their differentiation into downstream cell lineages.
Fli1 (show FLI1 Proteins) acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation in vasculogenesis.
Gata2 (show GATA2 Proteins) functions as a cofactor of Etv2 in the transcriptional regulation of mesodermal progenitors during embryogenesis.
study demonstrated using the embryonic stem cell/embryoid body system that Etv2 could rescue the Flk1 (show KDR Proteins) mutant phenotype, but Flk1 (show KDR Proteins) could not rescue the Etv2 mutant phenotype, further supporting the notion that the Flk1 (show KDR Proteins)-Etv2 cascade is operational during hemato-endothelial development
Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA-3' (By similarity).
ETS translocation variant 2
, ets variant 2
, ets variant gene 2
, Ets1-related protein
, v-ets erythroblastosis virus E26 oncogene homolog 1b
, ets-related protein 71
, ets related protein 71