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XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009].. Additionally we are shipping XPO4 Kits (1) and and many more products for this protein.
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XPO4 copy number variation duplication was associated with histological severity of non-alcoholic fatty liver disease.
Knockdown of exportins 4, 5, and 7 altered thyroid hormone receptor (show THRA Antibodies) shuttling dynamics, and when exportins 5 and 7 were overexpressed, TR distribution shifted toward the cytosol.
Methylation status of XPO4 in peripheral blood mononuclear cells (PBMCs) tended to be a noninvasive biomarker to predict hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and the progression of hepatitis B virus (HBV)infection.
These results demonstrate that Exp4 acts as a Sox9 (show SOX9 Antibodies) co-regulator that directly regulates binding of Sox9 (show SOX9 Antibodies) to its target genes.
Data suggest that XPO4 could be involved in the progression of human hepatocellular carcinoma.
A short peptide representing the minimal interaction domain in Smad3 (show SMAD3 Antibodies) effectively competes with Smad3 (show SMAD3 Antibodies) association to exportin 4 and blocks nuclear export of Smad3 (show SMAD3 Antibodies) in vivo.
Exp4 (exportin 4) is an interaction partner of Sox2 (show SOX2 Antibodies) in mouse embryonic stem cells and neural progenitors.
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000