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EYA2 encodes a member of the eyes absent (EYA) family of proteins. Additionally we are shipping EYA2 Proteins (6) and EYA2 Kits (1) and many more products for this protein.
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Eya2 in a physical complex with Six1 (show SIX1 Antibodies) plays a critical role in physiological hypertrophy.
Eya2 protein is required for hypaxial somitic myogenesis in the mouse embryo
Eya2 prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway.
SIX1 (show SIX1 Antibodies) and EYA are often co-overexpressed in tumors, and the SIX1 (show SIX1 Antibodies)-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model.
Decreased expression of EYA2 is associated with pancreatic adenocarcinomas.
This interaction suggests that CDK6 (show CDK6 Antibodies) regulates EYA2 activity, a mechanism that could be important in development and in cancer.
MIR30A represses Eya2 expression by binding to the 3'-untranslated region of Eya2.The MIR30A/EYA2 axis regulates breast cancer cell proliferation and migration.
Functional roles of candidate genes EYA2 (20q13) and hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-375 (2q35) were studied by siRNA-mediated knock-down and overexpression, respectively, in hrHPV-containing cell lines.
Given that SIX1 (show SIX1 Antibodies) and EYA are overexpressed in many tumor types, our data indicate that targeting the SIX1 (show SIX1 Antibodies)-EYA complex may be a potent approach to inhibit tumor progression in multiple cancer types
Studies indicate that the RNA and protein levels of Eya2 is upregulated in ovarian cancer.
Data implicate Eya2 as a necessary co-factor for many of the metastasis promoting functions of Six1 (show SIX1 Antibodies).
Expression of EYA2 in lung adenocarcinoma is augmented.
Based on observation that the dachshund-binding site is located between the catalytic core & Sine Oculis binding sites within ED-Eya2, we propose that catalytic activity can be translated to SO binding through DAC (show AADAC Antibodies), which acts as a transcriptional switch.
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.
eyes absent 2
, eyes absent homolog 2
, eyes absent homolog 2 (Drosophila)
, Drosophila-type eyes absent 2-like protein
, eyes absent 2 homolog