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anti-F-Box Protein 4 (FBXO4) Antibodies

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 4 Kits (15) and F-Box Protein 4 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FBXO4 26272 Q9UKT5
FBXO4 106052 Q8CHQ0
FBXO4 310363  
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Top anti-F-Box Protein 4 Antibodies at antibodies-online.com

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FBXO4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of FBXO4 Antibody (Center) (ABIN653243) in Y79 cell line lysates (35 µg/lane). FBXO4 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of FBXO4 Antibody (Center) in Y79 cell line lysates (35ug/lane). FBXO4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Whole cell extracts prepared from U2OS cells, or insect Sf9 cells expressing DYKDDDDK-FBX4, were resolved by SDS-PAGE and transferred to nitrocellulose. FBX4 was detected using anti-FBX4 at a 1:500 dilution, in TBS buffer containing 0.1% Tween-20, followed by peroxidase conjugated anti-rabbit IgG. 100 μL Log in to see 2 to 3 Days
$369.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-FBXO4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: OVCAR-3 cell lysate WB Suggested Anti-FBXO4  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: OVCAR-3 cell lysate  FBXO4 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, WB 0.1 mL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA Anti-FBXO4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN962656 concentration 41396 ug/ml. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details

FBXO4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-F-Box Protein 4 Antibodies

  1. Human Polyclonal FBXO4 Primary Antibody for EIA, WB - ABIN952288 : Zeng, Wang, Yang, Chen, Yang, Diehl, Liu, Lei: Structural basis of selective ubiquitination of TRF1 by SCFFbx4. in Developmental cell 2010 (PubMed)
    Show all 3 references for ABIN952288

  2. Human Polyclonal FBXO4 Primary Antibody for WB - ABIN233769 : Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. in Molecular and cellular biology 2008 (PubMed)
    Show all 3 references for ABIN233769

  3. Human Polyclonal FBXO4 Primary Antibody for WB - ABIN653243 : Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. in Cancer cell 2008 (PubMed)
    Show all 2 references for ABIN653243

  4. Cow (Bovine) Polyclonal FBXO4 Primary Antibody for WB - ABIN2774698 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in 2007 (PubMed)

More Antibodies against F-Box Protein 4 Interaction Partners

Human F-Box Protein 4 (FBXO4) interaction partners

  1. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 (show CCND1 Antibodies) degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 (show CCND1 Antibodies) expression in human cancers.

  2. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.

  3. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.

  4. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.

  5. results reveal an atypical small GTPase (show RACGAP1 Antibodies) domain within Fbx4 as a substrate-binding motif for SCF (show KITLG Antibodies)(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 (show TERF1 Antibodies) in telomere homeostasis control

  6. Fbx4 is a central regulator of Pin2/TRF1 (show TERF1 Antibodies) protein abundance and alterations in the stability of Pin2/TRF1 (show TERF1 Antibodies) can have a dramatic impact on telomere length

  7. SCF (show KITLG Antibodies)(FBX4-alphaB crystallin (show CRYAB Antibodies)) is an E3 ubiquitin ligase (show MUL1 Antibodies) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (show CCND1 Antibodies).

  8. Mutations in Fbx4 inhibit dimerization of the SCF (show KITLG Antibodies)(Fbx4) ligase and contribute to cyclin D1 (show CCND1 Antibodies) overexpression in human cancer.

Mouse (Murine) F-Box Protein 4 (FBXO4) interaction partners

  1. Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis

  2. This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.

  3. Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 (show CCND1 Antibodies) deregulation and nuclear accumulation

  4. SCF (show KITLG Antibodies)(FBX4-alphaB crystallin (show CRYAB Antibodies)) is an E3 ubiquitin ligase (show MUL1 Antibodies) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (show CCND1 Antibodies).

  5. Lysine 269 is essential for cyclin D1 (show CCND1 Antibodies) ubiquitylation by the SCF (show KITLG Antibodies)(Fbx4/alphaB-crystallin (show CRYAB Antibodies)) ligase.

F-Box Protein 4 (FBXO4) Antigen Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Gene names and symbols associated with anti-F-Box Protein 4 (FBXO4) Antibodies

  • F-box protein 4 (FBXO4) antibody
  • F-box protein 4 (fbxo4) antibody
  • F-box only protein 4 (fbx4) antibody
  • F-box protein 4 (Fbxo4) antibody
  • 1700096C12Rik antibody
  • AI851261 antibody
  • AW494535 antibody
  • Fbx4 antibody
  • FBXO4 antibody

Protein level used designations for anti-F-Box Protein 4 (FBXO4) Antibodies

F-box protein 4 , F-box only protein 4 , F-box only protein 4-like , F-box protein Fbx4

GENE ID SPECIES
431586 Gallus gallus
548694 Xenopus (Silurana) tropicalis
697007 Macaca mulatta
737372 Pan troglodytes
783766 Bos taurus
100158284 Xenopus laevis
100406305 Callithrix jacchus
100600195 Nomascus leucogenys
100194812 Salmo salar
26272 Homo sapiens
106052 Mus musculus
489220 Canis lupus familiaris
534852 Bos taurus
310363 Rattus norvegicus
101116349 Ovis aries
Selected quality suppliers for anti-F-Box Protein 4 (FBXO4) Antibodies
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