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F-Box and WD Repeat Domain Containing 8 Proteins (FBXW8)

FBXW8 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXW8 Antibodies (47) and FBXW8 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBXW8 26259 Q8N3Y1
Rat FBXW8 FBXW8 304522  
FBXW8 231672 Q8BIA4
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Top FBXW8 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

FBXW8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for F-Box and WD Repeat Domain Containing 8 (FBXW8) Interaction Partners

Human F-Box and WD Repeat Domain Containing 8 (FBXW8) interaction partners

  1. FBXW8 and PARK2 (show PARK2 Proteins) are sequestrated into insolubility by ATXN2 (show ATXN2 Proteins) PolyQ expansions, but only FBXW8 expression is dysregulated

  2. findings will shed light the role to mechanism of miR (show MLXIP Proteins)-218 in regulating JEG-3 cells proliferation via miR (show MLXIP Proteins)-218/Fbxw8 axis, and miR (show MLXIP Proteins)-218 may serve as a novel potential therapeutic target in human choriocarcinoma in the future

  3. CUL7/Fbxw8 ubiquitin ligase-mediated HPK1 (show MAP4K1 Proteins) degradation revealed a direct link and novel role of CUL7/Fbxw8 ubiquitin ligase in the MAPK (show MAPK1 Proteins) pathway, which plays a critical role in cell proliferation and differentiation.

  4. Dysregulation of Cul7 and Fbxw8 expression might affect trophoblast turnover in intrauterine growth restriction.

  5. Growth factor-stimulated TBC1D3 (show TBC1D3 Proteins) ubiquitination and degradation are regulated by its interaction with CUL7-Fbw8.

  6. Fbxw8 plays an essential role in the proliferation of human trophoblast cells, especially JEG-3 cells.

  7. FBXW8 plays an essential role in cancer cell proliferation throug (show CCND1 Proteins)h proteolysis of cyclin D1. It may (show CDK1 Proteins) present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively.

  8. FBXW8-CUL7 complex plays a significant role in growth control

Mouse (Murine) F-Box and WD Repeat Domain Containing 8 (FBXW8) interaction partners

  1. FBXW8 and PARK2 (show PARK2 Proteins) are sequestrated into insolubility by ATXN2 (show ATXN2 Proteins) PolyQ expansions, but only FBXW8 expression is dysregulated

  2. mTORC2 (show CRTC2 Proteins) negatively feeds back to IRS-1 (show IRS1 Proteins) via control of Fbw8 stability and localization.

  3. our data support the concept that expanded ATXN2 (show ATXN2 Proteins) undergoes progressive insolubility and affects PABPC1 (show PABPC1 Proteins) by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8.

  4. Depletion of FBXW8 caused a significant accumulation of cyclin D1 (show CCND1 Proteins), as well as sequestration of CDK1 (show CDK1 Proteins) in the cytoplasm. This resulted in a severe reduction of cell proliferation.

  5. Cul7 forms a heterodimeric complex with Cul1 (show CUL1 Proteins) in a manner dependent on Fbxw8.

  6. FBXW8-CUL7 complex plays a significant role in growth control

FBXW8 Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with FBXW8

  • F-box and WD repeat domain containing 8 (FBXW8)
  • F-box and WD repeat domain containing 8 (Fbxw8)
  • F-box and WD-40 domain protein 8 (Fbxw8)
  • 4930438M06Rik protein
  • FBW6 protein
  • FBW8 protein
  • Fbx29 protein
  • FBXO29 protein
  • FBXW6 protein

Protein level used designations for FBXW8

F-box and WD-40 domain protein 8 , F-box and WD-40 domain-containing protein 8 , F-box only protein 29 , F-box/WD repeat-containing protein 8 , F-box protein FBX29

GENE ID SPECIES
486288 Canis lupus familiaris
26259 Homo sapiens
787118 Bos taurus
304522 Rattus norvegicus
100728842 Cavia porcellus
101108081 Ovis aries
231672 Mus musculus
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