FBXW8 Products
(F-Box and WD Repeat Domain Containing 8 (FBXW8))
Categories
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
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Featured FBXW8 Categories
FBXW8 Antibodies
High quality antibodies with extensive validation data.
FBXW8 ELISA Kits
Reliable ELISA kits for a wide range of species.
FBXW8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended FBXW8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN654676
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (2)
Cat. No.
ABIN565252
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), EIA
Validations
- (4)
Cat. No.
ABIN952296
Quantity
0.4 mL
Datasheet
Datasheet
Recommended FBXW8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743139
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Sheep
Analytical Method
Validations
Cat. No.
ABIN1774044
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Dog
Analytical Method
Validations
Cat. No.
ABIN1769148
Quantity
96 tests
Datasheet
Datasheet
Recommended FBXW8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353882
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092555
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136178
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FBXW8 products
: "Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated." in: PLoS ONE, Vol. 10, Issue 3, pp. e0121089, (2015) (PubMed).: "The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 289, Issue 7, pp. 4009-17, (2014) (PubMed).
: "Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines." in: Nutrition and cancer, Vol. 65, Issue 7, pp. 1026-33, (2013) (PubMed).
: "Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction?" in: The journal of maternal-fetal & neonatal medicine, Vol. 25, Issue 11, pp. 2209-15, (2012) (PubMed).
: "Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells." in: Molecular biology reports, Vol. 38, Issue 3, pp. 1741-7, (2011) (PubMed).
: "A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 39, pp. 26759-70, (2008) (PubMed).
Synonyms and alternative names related to FBXW8
F-box and WD repeat domain containing 8 (FBXW8), F-box and WD repeat domain containing 8 (Fbxw8), ring finger protein, transmembrane 2 (RNFT2), F-box and WD-40 domain protein 8 (Fbxw8), 4930438M06Rik, FBW6, FBW8, FBX29, Fbx29, FBXO29, FBXW6Protein level used designations for FBXW8
- F-box and WD-40 domain protein 8
- F-box and WD-40 domain-containing protein 8
- F-box only protein 29
- F-box/WD repeat-containing protein 8
- F-box protein FBX29
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