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The protein encoded by FKBP3 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FK506 Binding Protein 3, 25kDa Proteins (26) and FK506 Binding Protein 3, 25kDa Kits (1) and many more products for this protein.
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targets of FKBP25 and its complex with rapamycin
analysis of the expression pattern of the Fkbp25 gene during cerebral cortical neurogenesis
Structural basis for nucleic acid recognition by FKBP25 has been uncovered.
proteomics study indicates that the nuclear pool of the FKBP25 targets various nuclear proteins that are crucial for packaging of DNA, chromatin remodeling and pre-mRNA splicing
FKBP25 is likely recruited to preribosomes to chaperone one of the protein components of the ribosome large subunit.
structure of a unique N-terminal domain motif in the FKBP (show FKBP7 Antibodies) family, FKBP25(1-73), high-resolution structures show a new fold composed of five small helices where H3 and H4 are tilted (show OTOP1 Antibodies) in a novel arrangement; called Basic Tilted (show OTOP1 Antibodies) Helix Bundle (BTHB) domain.
FKBP3, a novel regulator of the p53 (show TP53 Antibodies) pathway, induces the degradation of MDM2 (show MDM2 Antibodies) and activation of p53 (show TP53 Antibodies).
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
25 kDa FK506-binding protein
, 25 kDa FKBP
, FK506-binding protein 3 (25kD)
, PPIase FKBP3
, immunophilin FKBP25
, peptidyl-prolyl cis-trans isomerase FKBP3
, rapamycin-selective 25 kDa immunophilin
, FK506 binding protein 3, 25kDa
, FK506-binding protein 25, T-cell
, rapamycin binding protein
, putative FK506-binding protein
, FK506-binding protein 3
, potential nucleolar FKBP-type peptidylprolyl cis/trans isomerase