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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Antibodies (126) and FKBP5 Proteins (13) and many more products for this protein.
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FKBP51 (show FKBP4 ELISA Kits) is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (show FKBP4 ELISA Kits) (but not FKBP52 (show FKBP4 ELISA Kits)) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria.
The results show that the presence of the T allele of the FKBP5 SNP rs1360780 was associated with weight loss after bariatric surgery. Bariatric surgery can interact with genes involved in metabolic regulation, leading to different weight loss outcomes
The role of FKBP51 (show FKBP4 ELISA Kits) in intracellular pathways involved in adaptation is summarized.
we found no effect of early life trauma on heavy drinking in rs1360780*T-allele carriers, rs1360780*C homozygotes exposed to early life trauma had a lower probability of heavy drinking compared to rs1360780*C homozygotes not exposed to early life trauma (P < 0.01). There exists a developmental period of susceptibility to stress that is moderated by FKBP5 genotype.
LIF (show LIF ELISA Kits) and FKBP51 (show FKBP4 ELISA Kits) expression in epithelial cells were the most interesting markers of Airway epithelial cells dysfunction/response to corticosteroid treatment.
The data of this study show a significant increase in DNA methylation (show HELLS ELISA Kits) of FKBP5 in peripheral blood mononuclear cells of major depressive disorder patients.
Knockdown of FKBP51 (show FKBP4 ELISA Kits) alleviates neuropathic pain via inhibiting the NF-kappaB (show NFKB1 ELISA Kits) signaling in chronic constriction injury rat model.
we sought to extend prior GxE findings by examining the relation of four FKBP5 SNPs (rs9296158, rs3800373, rs1360780, rs947008), childhood abuse, and lifetime PTSD symptom severity. Results revealed that the four FKBP5 SNPs were associated with PTSD symptom severity in both samples . SNP rs9470080 in the main sample, and all four SNPs in the replication sample interacted with childhood abuse to predict PTSD severity
Findings suggest that posttraumatic stress disorder (PTSD) phenotypes may be characterized by differences in intracellular signaling transduction processes. The associations of expression of GRalpha and FKBP5 in the glucocorticoid (GC) high-sensitive PTSD subgroup may thereby reflect physiological adaptation to preserve immune-relevant GC signaling.
Associations between FKBP5 genotype and neurodevelopment; potential interaction between FKBP5 genotype and stress experiences (NICU) in preterm infants.
Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
important regulator of PPARgamma (show PPARG ELISA Kits) in white adipose tissue
FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
findings show that miR (show MLXIP ELISA Kits)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
We discovered that the suggested psychiatric risk factor FK506 binding protein (show FKBPL ELISA Kits) 51 (FKBP51) increases phosphorylation of GSK3beta (show GSK3b ELISA Kits) at serine 9 (pGSK3beta(S9)).
Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation (show HELLS ELISA Kits), and its subsequent regulation of glucocorticoid receptor (show NR3C1 ELISA Kits) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton
the abundance of BDNF (show BDNF ELISA Kits) positively correlated and phosphorylated DNMT1 (show DNMT1 ELISA Kits) inversely correlated with that of FKBP51 in cells
FKBP5 associates with BECN1 (show BECN1 ELISA Kits), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein