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Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. Additionally we are shipping Family with Sequence Similarity 175, Member B Antibodies (16) and many more products for this protein.
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In late S/G2 (show STRN3 Proteins) phase, the DNA damage-responsive E3 ligase RNF8 (show RNF8 Proteins) conjugates K63-linked ubiquitin chains to tankyrase 1 (show TNKS Proteins), while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1/BRCC36 (show BRCC3 Proteins)-containing deubiquitinase complex.
KIAA0157 allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 (show BRCC3 Proteins) DUB activity.
ABRO1 is a novel p53 (show TP53 Proteins) regulator that plays an important role in tumor suppression and the DNA damage response
Study identified Abro1 as a specific interactor of THAP5, a zinc finger transcription factor that is involved in G2/M control and apoptosis.
Abro1 deficiency results in increased chromosome instability, and Abro1-null mice are tumor-prone.
Data shows that the expression of Abro1 protein substantially increased (at least three-fold) in the hearts of mice that underwent MI/R compared to sham operated controls.
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex (By similarity).
BRISC complex subunit Abro1
, Abraxas brother protein 1
, Protein FAM175B
, family with sequence similarity 175, member B
, abraxas brother 1
, abraxas brother protein 1