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Fas (TNFRSF6) Associated Factor 1 Proteins (FAF1)

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. Additionally we are shipping Fas (TNFRSF6) Associated Factor 1 Antibodies (77) and Fas (TNFRSF6) Associated Factor 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FAF1 11124 Q9UNN5
FAF1 140657 Q924K2
FAF1 14084 P54731
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Top Fas (TNFRSF6) Associated Factor 1 Proteins at

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

FAF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Fas (TNFRSF6) Associated Factor 1 (FAF1) Interaction Partners

Pig (Porcine) Fas (TNFRSF6) Associated Factor 1 (FAF1) interaction partners

  1. This study reveals clear genetic-statistical evidence for a link of KRT8 (show KRT8 Proteins), FAF1 and PTH1R (show PTH1R Proteins) with some of leg weakness related traits in pigs.

Human Fas (TNFRSF6) Associated Factor 1 (FAF1) interaction partners

  1. FAF1 plays a novel role in negatively regulating virus-induced IFN-beta (show IFNB1 Proteins) production and the antiviral response by inhibiting the translocation of active, phosphorylated IRF3 (show IRF3 Proteins) from the cytosol to the nucleus

  2. Progression of the DNA replication fork is coordinated by FAF1. FAF1 binds to the licensing factor CDT-1 (show CDT1 Proteins) and additional ubiquitylated proteins, thus promoting CDC48 (show vcp Proteins)-dependent turnover and disassembly of DNA replication factor (show CDT1 Proteins) complexes.

  3. Report a novel role for FAF1 in regulating CD40-induced NFkappaB activation via a negative feedback loop.

  4. The repertoire of VAPB (show VAPB Proteins) interactors is more diverse than previously anticipated and link VAPB (show VAPB Proteins) to the function of ATPase complexes such as p97 (show EIF4G2 Proteins)/FAF1 and ASNA1 (show ASNA1 Proteins)/transmembrane-domain recognition complex.

  5. long-chain unsaturated fatty acids also induced polymerization of Fas-associated factor 1 (FAF1), the only other mammalian protein that contains a UAS domain homologous to that of Ubxd8 (show FAF2 Proteins)

  6. Data indicate that Npl4-Ufd1 (show UFD1L Proteins) heterodimer is required for VCP (show vcp Proteins)-FAF1 interaction.

  7. hFAF1 inhibits tumor formation by increasing the degradation of Hsp70 (show HSP70 Proteins) mediated via its UBA domain.

  8. Fas-associated factor 1 is a scaffold protein (show HOMER1 Proteins) that promotes beta-transducin repeat-containing protein (beta-TrCP (show BTRC Proteins))-mediated beta-catenin (show CTNNB1 Proteins) ubiquitination and degradation.

  9. Wild-type p97/VCP (show vcp Proteins) ND1 (show MT-ND1 Proteins) in complex with FAF1 UBX crystallized into very thin sheet-shaped crystals which turned out to be of poor diffraction quality

  10. The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 (show NLRP12 Proteins) pyrin (show MEFV Proteins) domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links the innate immune system to apoptotic signaling.

Mouse (Murine) Fas (TNFRSF6) Associated Factor 1 (FAF1) interaction partners

  1. Increased FAF1 expression triggers caspase-3 (show CASP3 Proteins) cleavage and activation, leading to hyperphosphorylated tau aggregation and subsequent neurofibrillary tangles formation, in turn initiating apoptosis.

  2. Taken together, these results suggest a new role for FAF1: that of a positive modulator for Parkinson's disease .

  3. FAF1 is a novel inhibitory factor of canonical Wnt (show WNT2 Proteins) signaling pathway

  4. Capsaicin-induced cancer cell apoptosis involves FAF1, a TRPV1 (show TRPV1 Proteins) associated protein.

  5. Analysis of FAF1 expression revealed that the protein is present in early preimplantation stages, while embryonic expression of Faf1 mRNA becomes appreciable at 4-cell stage.

  6. Data show that Faf1 protein level is down-regulated during apoptosis in a caspase-3 (show CASP3 Proteins)- and Apaf1 (show APAF1 Proteins)-dependent manner.

  7. analysis of the negative feedback regulation of Aurora-A (show AURKA Proteins) via phosphorylation of Fas-associated factor-1

Fas (TNFRSF6) Associated Factor 1 (FAF1) Protein Profile

Protein Summary

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.

Gene names and symbols associated with FAF1

  • Fas (TNFRSF6) associated factor 1 (faf1)
  • Fas (TNFRSF6) associated factor 1 (FAF1)
  • Fas associated factor 1 (faf1)
  • Fas (TNFRSF6) associated factor 1 (Faf1)
  • Fas-associated factor 1 (Faf1)
  • AA408698 protein
  • Dffrx protein
  • FAF1 protein
  • Fam protein
  • hFAF1 protein
  • HFAF1s protein
  • MGC53741 protein
  • MGC80303 protein
  • UBXD12 protein
  • UBXN3A protein
  • wu:fc25h12 protein
  • zgc:55752 protein

Protein level used designations for FAF1

Fas (TNFRSF6) associated factor 1 , FAS-associated factor 1 , FAS-associated factor 1-like , fc25h12 , TNFRSF6-associated factor 1 , UBX domain protein 3A , UBX domain-containing protein 12 , UBX domain-containing protein 3A

379909 Xenopus laevis
432299 Xenopus laevis
456846 Pan troglodytes
714405 Macaca mulatta
100021009 Monodelphis domestica
100078074 Ornithorhynchus anatinus
100395232 Callithrix jacchus
100459454 Pongo abelii
100472189 Ailuropoda melanoleuca
100518974 Sus scrofa
100546866 Meleagris gallopavo
100556583 Anolis carolinensis
406243 Danio rerio
11124 Homo sapiens
140657 Rattus norvegicus
531770 Bos taurus
14084 Mus musculus
424629 Gallus gallus
608231 Canis lupus familiaris
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