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FSCN1 encodes a member of the fascin family of actin-binding proteins. Additionally we are shipping Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Kits (23) and Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteins (18) and many more products for this protein.
Showing 4 out of 4 products:
Mouse (Murine) Polyclonal FSCN1 Primary Antibody for WB - ABIN610551
Attramadal, Arriza, Aoki, Dawson, Codina, Kwatra, Snyder, Caron, Lefkowitz: Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. in The Journal of biological chemistry 1992
Show all 3 references for ABIN610551
Human Polyclonal FSCN1 Primary Antibody for EIA, WB - ABIN452989
Qualtrough, Singh, Banu, Paraskeva, Pignatelli: The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro. in British journal of cancer 2009
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Dog (Canine) Polyclonal FSCN1 Primary Antibody for IF (p), IHC (p) - ABIN673011
Majchrzak, Lo Re, Gajewska, Bulkowska, Homa, Paw?owski, Motyl, Murphy, Król: Migrastatin analogues inhibit canine mammary cancer cell migration and invasion. in PLoS ONE 2013
Show all 2 references for ABIN673011
Human Polyclonal FSCN1 Primary Antibody for FACS, IHC (p) - ABIN390697
Ono, Yamakita, Yamashiro, Matsudaira, Gnarra, Obinata, Matsumura: Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. in The Journal of biological chemistry 1997
Show all 2 references for ABIN390697
Human Polyclonal FSCN1 Primary Antibody for WB - ABIN442669
Law, Li, Chou, Chen, Chan: Hyaluronic acid-dependent protection in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. in Toxicology 2013
Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.
essential for actin bundle initiation and stiffening during embryonic tracheal system development
Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.
Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.
These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling
The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.
The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.
Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.
Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.
study found that Rab35 (show RAB35 Antibodies) regulates the assembly of actin (show ACTB Antibodies) filaments during bristle development; effect was mediated by the a (show ACTB Antibodies)ctin-bundling protein fascin, which directly associated with active R (show RAB35 Antibodies)ab35
These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation
Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.
Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3 (show MAP1LC3A Antibodies), an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.
A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.
fascin 1 promotes cell migration and has a role in growth and cell cycle progression
Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia (show KAT6B Antibodies) RAW264.7 macrophages.
Both STAT3 (show STAT3 Antibodies) and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.
fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development
We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.
Fascin is a novel target of beta-catenin (show CTNNB1 Antibodies)-TCF (show HNF4A Antibodies) signaling and is expressed at the invasive front of human colon cancer
Fascin mRNA & protein levels were significantly lower in the cultured ANXA2 (show ANXA2 Antibodies)(-/-) cells than in cultured ANXA2 (show ANXA2 Antibodies)(+/+) cells. ANXA2 (show ANXA2 Antibodies) may be an inducer or enhancer of fascin expression at the transcription level.
fascin expression promotes cholangiocarcinoma RBE cell proliferation, migration, and invasion.
TGF-beta1 (show TGFB1 Antibodies) could induce the expressions of Fascin1 mRNA and protein and thus improve the invasive and metastatic ability of human renal carcinoma (show TSC2 Antibodies) cells.
elevated L-plastin (show LCP1 Antibodies) expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin (show LCP1 Antibodies) than fascin levels.
Study demonstrates that FSCN1 is associated with increased risk of recurrence in pituitary adenomas and invasion, partially through modifying the expression of Notch (show NOTCH1 Antibodies)/DLL pathway.
The present study revealed an antioncogenic role of miR145 in gastric carcinoma via inhibition of FSCN1, and suggested that miR145 may be used for the treatment of gastric carcinoma.
miR (show MLXIP Antibodies)-145 negatively regulates the protein expression of its target FSCN1 in the NSCLC cell line H129.
MiR (show MLXIP Antibodies)-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1
Strong fascin-1 expression was found in 14.3% of borderline epithelial tumors of the ovary and linked to features related to elevated risk of recurrence.
FSCN1 plays an important role in non-small cell lung cancer progression and prognosis.
FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
, fascin 1
, singed-like protein
, 55 kDa actin-bundling protein
, singed-like (fascin homolog, sea urchin)