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The protein encoded by FAP is a homodimeric integral membrane gelatinase belonging to the serine protease family. Additionally we are shipping Fibroblast Activation Protein, alpha Kits (21) and Fibroblast Activation Protein, alpha Proteins (16) and many more products for this protein.
Showing 10 out of 133 products:
Human Polyclonal FAP Primary Antibody for EIA, WB - ABIN401430
Cheng, Valianou, Canutescu, Jaffe, Lee, Wang, Lai, Bachovchin, Weiner: Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth. in Molecular cancer therapeutics 2005
Show all 8 references for ABIN401430
Human Monoclonal FAP Primary Antibody for WB - ABIN394545
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 5 references for ABIN394545
Human Monoclonal FAP Primary Antibody for IP, ELISA - ABIN560844
Wang, Yao, Nadvi, Osborne, McCaughan, Gorrell: Fibroblast activation protein and chronic liver disease. in Frontiers in bioscience : a journal and virtual library 2007
Show all 4 references for ABIN560844
Human Polyclonal FAP Primary Antibody for WB - ABIN656472
Chen, Yang, Wen, Xu, Chen: TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM [corrected]. in Experimental and molecular pathology 2009
Soluble form of a seprase activity is detected in bovine serum
We clearly show an association between FAPalpha and chondrocytes in the context of cartilage degradation. (Fibroblast activation protein alpha)
In two different models of pulmonary fibrosis, intratracheal bleomycin instillation and thoracic irradiation, the study finds increased mortality and increased lung fibrosis in FAP-deficient mice compared with wild-type mice.
Mouse FGF-21 (show FGF21 Antibodies), however, lacks the FAP cleavage site and is not cleaved by FAP.
Data indicate that indolamine-2,3-dioxygenase (IDO (show IDO1 Antibodies)) and Fibroblast activation protein alpha (FAPalpha) were detectable in B16 melanoma tumor-bearing mice.
A transgenic mouse model for pulmonary fibrosis was generated. After bleomycin induction, luciferase cDNA under the control of the FAPa promoter presents strong luminescence in the lungs especially; the expression level reflects the degree of the disease.
Results indicate a bacterial adaptation that hijacks inflammasome activation via interactions between IpaH7.8 E3 ubiquitin ligase (show MUL1 Antibodies) and glomulin (GLMN (show GLMN Antibodies)).
The FAP(+) stromal cell may have roles in two adverse consequences of cancer.
In NIH 3T3 cells overexpressing recombinant mouse FAP, FAP enzymatic activity during matrix production is important for the topographical organization of the ECM (show MMRN1 Antibodies) fibers.
Authors conclude that the proteolytic activity of FAP participates in matrix degradation, but other functions of the protein stimulate increased tumor growth.
FAP may be a potentially useful marker for wound age determination.
Results suggest that FAP, a product preferentially expressed by TAF, could function as an effective tumor rejection antigen.
degradomic study highlights cell-contextual proteolysis by FAPalpha with distinct positional profiles. Generally, our findings link FAPalpha to key aspects of CAF (show KAT2B Antibodies) biology and attribute an important role in tumor-stroma interaction to FAPalpha
Data suggest that a DNA vaccine targeting human fibroblast activation protein alpha (FAPalpha) may be an attractive and effective cancer immunotherapy strategy.
In this study, we show for the first time the expression of FAP in activated fibroblasts after MI and its activation by TGFbeta1 (show TGFB1 Antibodies). Effects of FAP on fibroblast migration and gelatinolytic activity indicate a potential role in cardiac wound healing
FAP is expressed by activated, collagen-synthesizing fibroblasts, but not by inactive fibroblasts or fully differentiated myofibroblasts and non-fibroblast cells in the infarct.
This study identified fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21 (show FGF21 Antibodies).
Human FGF-21 (show FGF21 Antibodies) Is a Substrate of Fibroblast Activation Protein.
FAP selectively cleaves type I collagen resulting in increased macrophage adhesion.
FAP sensitizes fibrosarcoma to chemotherapy and alters cell death.
Data show that FAP and DPP4 (show DPP4 Antibodies) proteins were simultaneously induced in dedifferentiating mature adipocytes supporting a potential role for these enzymes in adipose tissue remodeling and cell plasticity.
FAP expression is associated with worse prognosis in solid tumors
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
fibroblast activation protein, alpha
, fibroblast activation protein, alpha subunit
, gene 13
, fibroblast activation protein alpha
, integral membrane serine protease
, 170 kDa melanoma membrane-bound gelatinase
, FK506-binding protein-associated protein
, FKBP-associated protein