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FPGS encodes the folylpolyglutamate synthetase enzyme. Additionally we are shipping FPGS Proteins (3) and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal FPGS Primary Antibody for EIA, WB - ABIN453030
Sharma, Das, Kumar, Marwaha, Shankar, Aneja, Grover, Arya, Dhir, Gupta, Kumar, Juyal, B K: Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians. in Pharmacogenetics and genomics 2008
the highest expression of GGH (show GGH Antibodies) and EGFR (show EGFR Antibodies) was noted in the left-sided colon; the highest expression of DHFR (show DHFR Antibodies), FPGS, TOP1 (show TOP1 Antibodies) and ERCC1 (show ERCC1 Antibodies) was noted in the rectosigmoid, whereas TYMP (show TYMP Antibodies) expression was approximately equivalent in the right-sided colon and rectum
FPGS and ABCB1 (show ABCB1 Antibodies) genetic variants can influence the outcome in RA patients receiving MTX (show MTX1 Antibodies) monotherapy.
Genetic polymorphisms in the FPGS coding region are significantly associated with increased Acute Lymphoblastic Leukemia risk.
study found that genetic polymorphism of FPGS rs10760502A > G is associated with susceptibility to primary retroperitoneal liposasrcoma
antifolate resistant leukemia cells harbor a heterozygous point mutation in exon12 of FPGS which disrupts FPGS activity by abolishing ATP binding, and alters the binding pattern of transcription factors to the genomic region of exon12.
Genome-wide association studies identify 10 novel genetic loci as risk factors for methotrexate response in rheumatoid arthritis patients additionally to polymorphism in DHFR (show DHFR Antibodies), FPGS and TYMS (show TYMS Antibodies).
mitochondrial FPGS is required because folate polyglutamates are not substrates for transport across the mitochondrial membrane
Polymorphism of FPGS rs1544105 G>A is associated with response to therapy in acute lymphoblastic leukemia.
An interaction term, between FPGS rs7033913 heterozygotes and GGH (show GGH Antibodies) rs11988534 homozygotes for the minor allele, had a p-value <0.0001 and may contribute to methotrexate toxicity in rheumatoid arthritis.
High Folylpoly-glutamate (show GRIN1 Antibodies) synthetase expression is associated with response to therapy in non-small-cell lung cancer.
These results suggest that FPGS and GGH (show GGH Antibodies) expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU.
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
, folylpolyglutamate synthase, mitochondrial
, folylpolyglutamate synthase
, folylpoly-gamma-glutamate synthetase
, tetrahydrofolate synthase
, tetrahydrofolylpolyglutamate synthase
, Folylpoly-gamma-glutamate synthetase
, Tetrahydrofolate synthase
, Tetrahydrofolylpolyglutamate synthase
, folylpoly-gammaglutamate synthetase