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Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. Additionally we are shipping FOXN4 Proteins (2) and many more products for this protein.
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adult thymus is the only major site of foxn4 expression outside of the nervous system
the mosaic expression of Foxn4 and proneural factors may serve as the trigger to initiate asymmetric Dll4 (show DLL4 Antibodies)-Notch (show NOTCH1 Antibodies) and subsequent BMP/TGFbeta (show TGFb Antibodies) signaling events required for neuronal diversity in the V2 domain.
Mouse Foxn4 transfection reduced by 2.7-fold the basal level of Tbx2 (show TBX2 Antibodies) promoter transcription, but deletion of the AD domain increased transcription showing that this domain might be a transregulatory domain.
Foxn4 has an intrinsic activity to suppress the alternative photoreceptor cell fates of early retinal progenitors by selectively activating Dll4 (show DLL4 Antibodies)-Notch (show NOTCH1 Antibodies) signaling.
Foxn4 may have a non-cell-autonomous role critical for alveologenesis during lung development.
findings show that Foxn4 is required for proper outgrowth of retinal ganglion cell (RGC) axons in vivo, suggesting a role for an amacrine cell-RGC interaction in axon growth
Foxn4 acts synergistically with Mash1 (show ASCL1 Antibodies) to specify subtype identity of V2 interneurons in the spinal cord.
Foxn4 induces expression of delta-like (show DLK1 Antibodies) 4 (Dll4 (show DLL4 Antibodies)) and Mash1 (Ascl1 (show ASCL1 Antibodies)). Dll4 (show DLL4 Antibodies) then signals through Notch1 (show NOTCH1 Antibodies) to subdivide the p2 progenitor pool in the ventral spinal cord.
The results indicate that Foxn4 complements Foxj1 (show FOXJ1 Antibodies) transcriptionally during Multiciliated cell differentiation, thereby shaping the levels of gene expression required for the timely and complete biogenesis of multiple motile cilia.
Study reports that FoxN4 is expressed in the eye from the earliest stages of specification through retinal maturation, it is also expressed in the pallium, optic tectum, isthmus, reticular formation, and in cells lining the ventricle of the tadpole brain.
Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004
forkhead box protein N4
, forkhead box N4
, forkhead box protein N4-like
, forkhead/winged helix transcription factor FOXN4
, winged helix nude
, forkhead box protein FoxN4