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anti-Frataxin (FXN) Antibodies

This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. Additionally we are shipping Frataxin Proteins (23) and Frataxin Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FXN 2395 Q16595
FXN 499335  
FXN 14297 O35943
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Top anti-Frataxin Antibodies at antibodies-online.com

Showing 10 out of 138 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p) 0.1 mg Log in to see 6 to 8 Days
$489.50
Details
Human Rabbit Un-conjugated WB FXN Antibody (N-term) (ABIN1881356) western blot analysis in SK-BR-3 c... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Fxn AntibodyTitration: 1.0 µg/mL  Positive Control: ... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of FXN (arrow) using rabbit polyclonal FXN Antib... Western blot analysis of anti-FXN Antibody (C-term) (ABIN390377) in 29... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of FXN Antibody (Center) (ABIN390378) in CEM cel... Formalin-fixed and paraffin-embedded human colon carcinoma tissue reac... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) Formalin-fixed and paraffin-embedded human colon carcinoma tissue reac... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human lung carcinoma tissue react... (LEFT)Western blot analysis of FXN (arrow) using rabbit polyclonal FXN... 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IF, WB Anti-FXN mouse monoclonal antibody (ABIN2455598) immunofluorescent sta... HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane... 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane... 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC204880 overexpress plasmid (Re... HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane... 100 μL Log in to see 2 to 3 Days
$423.50
Details

FXN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,
Rat (Rattus) , , , ,

Mouse (Murine) , , , ,

Top referenced anti-Frataxin Antibodies

  1. Human Polyclonal Frataxin Primary Antibody for WB - ABIN1881356 : Tsai, Barondeau: Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex. in Biochemistry 2010 (PubMed)
    Show all 4 references for ABIN1881356

  2. Human Monoclonal Frataxin Primary Antibody for IHC (p) - ABIN781667 : Sturm, Bistrich, Schranzhofer, Sarsero, Rauen, Scheiber-Mojdehkar, de Groot, Ioannou, Petrat: Friedreich's ataxia, no changes in mitochondrial labile iron in human lymphoblasts and fibroblasts: a decrease in antioxidative capacity? in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN781667

More Antibodies against Frataxin Interaction Partners

Fruit Fly (Drosophila melanogaster) Frataxin (FXN) interaction partners

  1. Frataxin overexpression in the nervous system reduces life span, impairs locomotor ability and causes brain degeneration.

  2. Strong involvement of glial cells and lipid peroxidation in the generation of Friedreich's ataxia (show USP14 Antibodies).

  3. Defects in axonal transport of mitochondria appear late in development in distal nerve of larvae showing reduced frataxin expression, with retrograde movement preferentially affected.

  4. H2O2 is an important pathogenic substrate underlying the phenotypes arising from frataxin deficiency in Drosophila

  5. This suggests that Drosophila frataxin may function to protect the mitochondria from oxidative stresses and the ensuing cellular damage.

  6. Dfh-assisted assembly of Fe-S clusters occurs with an observed kinetic rate constant ( k obs (show LEP Antibodies)) of 0.096 min (-1 (show CD59 Antibodies))

Human Frataxin (FXN) interaction partners

  1. In compound heterozygotes, expression of partially functional mutant frataxin delays age of onset and reduces diabetes mellitus, compared to those with no frataxin expression from the non-expanded allele.

  2. FXN promoter function was directly measured via metabolic labeling of newly synthesized transcripts in fibroblasts, which revealed that the YG8sR mouse was significantly deficient in transcriptional initiation compared to the Y47R mouse.

  3. Thus, Src (show SRC Antibodies) inhibitors emerge as a new class of drugs able to promote frataxin accumulation, suggesting their possible use as therapeutics in Friedreich's Ataxia (show USP14 Antibodies)

  4. Engineered a cell line where the presence of an exogenous, inducible FXN gene rescues the cells from the knockout of the two endogenous FXN genes. This system allows the possibility of testing the progression of disease.

  5. The region of chromosome 9 carrying the FXN gene is prone to chromosomal rearrangements in both control and Friedreich ataxia patient cells.

  6. Expanded GAA (show GAA Antibodies) repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells

  7. Findings confirm a detrimental effect of frataxin silencing, not only for astrocytes, but also for neuron-glia interactions, underlining the need to take into account the role of non-cell autonomous processes in Friedreich's ataxia (show USP14 Antibodies).

  8. We propose a model of premature termination of FXN transcription induced by pathogenic expanded GAA (show GAA Antibodies) repeats that links R-loop structures, antisense transcription, and heterochromatin formation

  9. Patients with a FXN p.R165P missense mutation progress to a less disabling disease state than typical Friedreich ataxia patients

  10. FXN accelerates a rate-limiting sulfur transfer step in the synthesis of [2Fe-2S] clusters on the human Fe-S assembly complex.

Mouse (Murine) Frataxin (FXN) interaction partners

  1. Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34

  2. Frataxin-deficient mice, which had higher mitochondrial iron loading, showed impaired airway mucociliary clearance and higher pulmonary inflammation at baseline.

  3. Using a mouse model of hepatic FXN deficiency in combination with mice deficient for IRP1 (show ACO1 Antibodies), a key regulator of cellular iron metabolism, we show that IRP1 (show ACO1 Antibodies) activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool

  4. The Fxn KO/Mck (show CKM Antibodies) mice tested from one to two months of age showed abnormal gait patterns accompanied by a loss in motor skills

  5. Reduced expression of frataxin in Friedreich's ataxia (show USP14 Antibodies) leads to elevation of COX2 (show COX2 Antibodies)-mediated oxylipin synthesis stimulated by increases in transcription factors that respond to increased reactive oxygen species.

  6. Frataxin-deficient cells showed a specific inhibition of mitochondrial Complex I activity already at 70% residual frataxin levels, whereas the glutathione imbalance progressively increased after silencing.

  7. The results support a mechanistic hypothesis in which frataxin deficiency decreases Nrf2 expression in vivo, causing the sensitivity to oxidative stress in target tissues the DRG and the cerebella, which contributes to the process of neurodegeneration.

  8. rescue of the Friedreich ataxia knockout mutation in transgenic mice containing an FXN-EGFP genomic reporter

  9. these results indicate that IGF-I (show IGF1 Antibodies) exerts cell-context neuroprotection in frataxin deficiency that maybe therapeutically effective.

  10. Data show that the respiratory chain defects accompanying frataxin deficiency cause progressive hyperacetylation of cardiac mitochondrial proteins due to the inhibition of SIRT3 (show SIRT3 Antibodies) deacetylase.

Frataxin (FXN) Antigen Profile

Protein Summary

This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Frataxin (FXN) Antibodies

  • frataxin (fxn) antibody
  • frataxin (LOC100284365) antibody
  • frataxin (TVAG_182150) antibody
  • frataxin homolog (fh) antibody
  • frataxin (FTX1) antibody
  • frataxin (FXN) antibody
  • frataxin (Fxn) antibody
  • BcDNA:AT09528 antibody
  • CG8971 antibody
  • CyaY antibody
  • dfh antibody
  • Dmel\\CG8971 antibody
  • FA antibody
  • FARR antibody
  • Frda antibody
  • LOC100284365 antibody
  • RGD1565754 antibody
  • X25 antibody
  • zgc:158218 antibody

Protein level used designations for anti-Frataxin (FXN) Antibodies

DKEYP-118A9.1 , frataxin, mitochondrial , frataxin , CG8971-PA , CG8971-PB , fh-PA , fh-PB , frataxin homologue , frataxin-like , Friedreich ataxia protein , Friedreich ataxia

GENE ID SPECIES
556389 Danio rerio
100284365 Zea mays
5468558 Trichomonas vaginalis G3
31845 Drosophila melanogaster
5718448 Chlamydomonas reinhardtii
2395 Homo sapiens
499335 Rattus norvegicus
14297 Mus musculus
505694 Bos taurus
427244 Gallus gallus
609051 Canis lupus familiaris
Selected quality suppliers for anti-Frataxin (FXN) Antibodies
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