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anti-Frataxin (FXN) Antibodies

This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. Additionally we are shipping Frataxin Proteins (23) and Frataxin Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FXN 2395 Q16595
FXN 499335  
FXN 14297 O35943
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Top anti-Frataxin Antibodies at antibodies-online.com

Showing 10 out of 139 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC (p) 0.1 mg Log in to see 6 to 8 Days
$599.50
Details
Human Rabbit Un-conjugated WB FXN Antibody (N-term) (ABIN1881356) western blot analysis in SK-BR-3 cell line lysates (35 µg/lane). This demonstrates the FXN antibody detected the FXN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Fxn AntibodyTitration: 1.0 µg/mL  Positive Control: Rat Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of FXN (arrow) using rabbit polyclonal FXN Antibody (C-term) (ABIN390377). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the FXN gene (Lane 2) (Origene Technologies). Western blot analysis of anti-FXN Antibody (C-term) (ABIN390377) in 293 cell line lysates (35 µg/lane). FXN (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of FXN Antibody (Center) (ABIN390378) in CEM cell line lysates (35 µg/lane). FXN (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with FXN antibody (Center)(ABIN390378), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with FXN antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FXN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FXN. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, WB HEK293T cells transfected with either RC204880 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-FXN antibody (ABIN2455528), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FXN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FXN. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, WB Anti-FXN mouse monoclonal antibody (ABIN2455598) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FXN (RC204880). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FXN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FXN. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-FXN mouse monoclonal antibody (ABIN2455527) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FXN (RC204880). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FXN (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FXN. 100 μL Log in to see 2 to 3 Days
$482.90
Details

FXN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Rat (Rattus) ,


Mouse (Murine) ,


Top referenced anti-Frataxin Antibodies

  1. Human Polyclonal Frataxin Primary Antibody for WB - ABIN1881356 : Tsai, Barondeau: Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex. in Biochemistry 2010 (PubMed)
    Show all 4 references for ABIN1881356

  2. Human Monoclonal Frataxin Primary Antibody for IHC (p) - ABIN781667 : Sturm, Bistrich, Schranzhofer, Sarsero, Rauen, Scheiber-Mojdehkar, de Groot, Ioannou, Petrat: Friedreich's ataxia, no changes in mitochondrial labile iron in human lymphoblasts and fibroblasts: a decrease in antioxidative capacity? in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN781667

More Antibodies against Frataxin Interaction Partners

Fruit Fly (Drosophila melanogaster) Frataxin (FXN) interaction partners

  1. Frataxin overexpression in the nervous system reduces life span, impairs locomotor ability and causes brain degeneration.

  2. Strong involvement of glial cells and lipid peroxidation in the generation of Friedreich's ataxia (show USP14 Antibodies).

  3. Defects in axonal transport of mitochondria appear late in development in distal nerve of larvae showing reduced frataxin expression, with retrograde movement preferentially affected.

  4. H2O2 is an important pathogenic substrate underlying the phenotypes arising from frataxin deficiency in Drosophila

  5. This suggests that Drosophila frataxin may function to protect the mitochondria from oxidative stresses and the ensuing cellular damage.

  6. Dfh-assisted assembly of Fe-S clusters occurs with an observed kinetic rate constant ( k obs (show LEP Antibodies)) of 0.096 min (-1 (show CD59 Antibodies))

Human Frataxin (FXN) interaction partners

  1. The differentially expressed FXN regulates the development of congenital heart disease (CHD (show CHDH Antibodies)) and the differential expression was under the control of miRNA-145. These results might provide new insight into the understanding of CHD (show CHDH Antibodies) pathogenesis and may facilitate further therapeutic studies.

  2. Results presented here shed light on the folding mechanism of frataxin, opening the possibility of mutating it to generate hyperstable variants without altering their folding kinetics.

  3. relative FXN expression in the patients was found to be correlated with the levels of MDA and ferritin (show FTL Antibodies) but not correlated with transferrin (show Tf Antibodies) saturation

  4. Frataxin (FXN) gene mutations lead to mitochondrial iron accumulation without total body/organ iron overload. The clinical consequences are spinocerebellar degeneration and frequent cardiomyopathy.

  5. Our results imply that regulation of FXN protein levels is complex and that total amounts can be modulated chemically and genetically without altering the absolute amount of mature FXN protein.

  6. In compound heterozygotes, expression of partially functional mutant frataxin delays age of onset and reduces diabetes mellitus, compared to those with no frataxin expression from the non-expanded allele.

  7. FXN promoter function was directly measured via metabolic labeling of newly synthesized transcripts in fibroblasts, which revealed that the YG8sR mouse was significantly deficient in transcriptional initiation compared to the Y47R mouse.

  8. Thus, Src (show SRC Antibodies) inhibitors emerge as a new class of drugs able to promote frataxin accumulation, suggesting their possible use as therapeutics in Friedreich's Ataxia (show USP14 Antibodies)

  9. Engineered a cell line where the presence of an exogenous, inducible FXN gene rescues the cells from the knockout of the two endogenous FXN genes. This system allows the possibility of testing the progression of disease.

  10. The region of chromosome 9 carrying the FXN gene is prone to chromosomal rearrangements in both control and Friedreich ataxia patient cells.

Mouse (Murine) Frataxin (FXN) interaction partners

  1. Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34

  2. Frataxin-deficient mice, which had higher mitochondrial iron loading, showed impaired airway mucociliary clearance and higher pulmonary inflammation at baseline.

  3. Using a mouse model of hepatic FXN deficiency in combination with mice deficient for IRP1 (show ACO1 Antibodies), a key regulator of cellular iron metabolism, we show that IRP1 (show ACO1 Antibodies) activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool

  4. The Fxn KO/Mck (show CKM Antibodies) mice tested from one to two months of age showed abnormal gait patterns accompanied by a loss in motor skills

  5. Reduced expression of frataxin in Friedreich's ataxia (show USP14 Antibodies) leads to elevation of COX2 (show COX2 Antibodies)-mediated oxylipin synthesis stimulated by increases in transcription factors that respond to increased reactive oxygen species.

  6. Frataxin-deficient cells showed a specific inhibition of mitochondrial Complex I activity already at 70% residual frataxin levels, whereas the glutathione imbalance progressively increased after silencing.

  7. The results support a mechanistic hypothesis in which frataxin deficiency decreases Nrf2 expression in vivo, causing the sensitivity to oxidative stress in target tissues the DRG and the cerebella, which contributes to the process of neurodegeneration.

  8. rescue of the Friedreich ataxia knockout mutation in transgenic mice containing an FXN-EGFP genomic reporter

  9. these results indicate that IGF-I (show IGF1 Antibodies) exerts cell-context neuroprotection in frataxin deficiency that maybe therapeutically effective.

  10. Data show that the respiratory chain defects accompanying frataxin deficiency cause progressive hyperacetylation of cardiac mitochondrial proteins due to the inhibition of SIRT3 (show SIRT3 Antibodies) deacetylase.

Frataxin (FXN) Antigen Profile

Protein Summary

This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Frataxin (FXN) Antibodies

  • frataxin (fxn) antibody
  • frataxin (LOC100284365) antibody
  • frataxin (TVAG_182150) antibody
  • frataxin homolog (fh) antibody
  • frataxin (FTX1) antibody
  • frataxin (FXN) antibody
  • frataxin (Fxn) antibody
  • BcDNA:AT09528 antibody
  • CG8971 antibody
  • CyaY antibody
  • dfh antibody
  • Dmel\\CG8971 antibody
  • FA antibody
  • FARR antibody
  • Frda antibody
  • LOC100284365 antibody
  • RGD1565754 antibody
  • X25 antibody
  • zgc:158218 antibody

Protein level used designations for anti-Frataxin (FXN) Antibodies

DKEYP-118A9.1 , frataxin, mitochondrial , frataxin , CG8971-PA , CG8971-PB , fh-PA , fh-PB , frataxin homologue , frataxin-like , Friedreich ataxia protein , Friedreich ataxia

GENE ID SPECIES
556389 Danio rerio
100284365 Zea mays
5468558 Trichomonas vaginalis G3
31845 Drosophila melanogaster
5718448 Chlamydomonas reinhardtii
2395 Homo sapiens
499335 Rattus norvegicus
14297 Mus musculus
505694 Bos taurus
427244 Gallus gallus
609051 Canis lupus familiaris
Selected quality suppliers for anti-Frataxin (FXN) Antibodies
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