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The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Additionally we are shipping FRAT2 Antibodies (53) and FRAT2 Proteins (3) and many more products for this protein.
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Data show that MLL (show MLL ELISA Kits) fusion oncogenes maintain leukemia-associated Rac (show AKT1 ELISA Kits) GTPases activity by regulating Frat gene expression, specifically Frat2.
Data show that that Frat synergizes with Diversin (show ANKRD6 ELISA Kits) in the activation of JNK (show MAPK8 ELISA Kits)/AP-1 (show JUN ELISA Kits) signaling.
FRAT-2 enhances glycogen synthase kinase 3 beta (show GSK3b ELISA Kits)-mediated phosphorylation of a primed substrate to a greater extent than an unprimed substrate
It suggests that activation of GSK-3 inhibits PP-2A through up-regulation of I(2)(PP-2A) with hnRNP A18-involved mechanism.
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.
GSK-3 binding protein FRAT2
, frequently rearranged in advanced T-cell lymphomas 2
, GSK-3-binding protein FRAT2