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GPRC5A encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. Additionally we are shipping G Protein-Coupled Receptor, Family C, Group 5, Member A Kits (30) and G Protein-Coupled Receptor, Family C, Group 5, Member A Proteins (5) and many more products for this protein.
Showing 10 out of 96 products:
Human Polyclonal GPRC5A Primary Antibody for EIA, WB - ABIN358729
Robbins, Michalovich, Hill, Calver, Medhurst, Gloger, Sims, Middlemiss, Pangalos: Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). in Genomics 2000
Show all 3 references for ABIN358729
Cow (Bovine) Polyclonal GPRC5A Primary Antibody for WB - ABIN2776866
Wu, Ding, Mirza, Van Arsdale, Wei, Bishop, Basso, McClanahan, Luo, Kirschmeier, Gustafson, Hernandez, Liu: Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target. in The Journal of biological chemistry 2005
Human Polyclonal GPRC5A Primary Antibody for ELISA, WB - ABIN1535989
Matsumoto, Kamohara, Sugimoto, Hidaka, Takasaki, Saito, Okada, Yamaguchi, Furuichi: The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors. in Gene 2000
Results show how GPRC5A deficiency leads to dysregulated EGFR (show EGFR Antibodies) and STAT3 (show STAT3 Antibodies) signaling and lung tumorigenesis.
EGFR (show EGFR Antibodies) interacted with GPRC5A and phosphorylated it in two conserved double-tyrosine motifs, Y317/Y320 and Y347/ Y350, at the C-terminal tail of GPRC5A.
The interaction of miR (show MLXIP Antibodies)-103a-3p with each of the two 5' UTR (show UTS2R Antibodies) targets reduces the expression levels of both GPRC5A mRNA and GPRC5A protein in one normal epithelial and two pancreatic cancer cell lines.
RAI3 may contribute to the malignant progression of hepatocellular carcinoma
Data indicate that in mammary tumors, the mRNA expression of GPRC5A significantly correlated with that of BRCA1.
Decreased GPRC5A expression is associated with non-small cell lung cancers and lung inflammation.
Loss of GPRC5A is associated with lung adenocarcinomas.
RAI3 is a cell growth-promoting gene and a novel P53 (show TP53 Antibodies) transcriptional target
This evidence explains one of the mechanisms of the GPRC5A-regulated cell growth in some cancer cell lines.
Gprc5a functions as a tumor suppressor in mouse lung, and human GPRC5A may share this property.
Gprc5a deficiency leads to impaired induction of peripherally derived regulatory T-cells and increased experimental autoimmune encephalomyelitis severity.
Gprc5a deficiency confers susceptibility to endotoxin-induced pulmonary edema and injury, mainly through NF-kappaB (show NFKB1 Antibodies) signaling in bronchioalveolar epithelium of lung.
Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 (show STAT3 Antibodies) signaling induced by autocrine leukemia inhibitory factor (show LIF Antibodies).
Gprc5a loss enhances NF-kappaB (show NFKB1 Antibodies) activation in lung epithelial cells
analysis of the Rai3 gene promoter revealed that the proximal region harbors most of the elements necessary for its regulation, including GC boxes and Sp1 (show SP1 Antibodies)-, AP1 (show JUN Antibodies)-, and AP2 (show TFAP2A Antibodies)-binding sites, and a retinoic acid response element
Data show that targeted inactivation of Raig1 did not cause significant developmental defects, and tha epithelial cell differentiation was normal and lung structure was intact.
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.
G-protein coupled receptor family C group 5 member A
, orphan G-protein-coupling receptor PEIG-1
, retinoic acid induced 3
, retinoic acid responsive
, retinoic acid-induced gene 1 protein
, retinoic acid-induced protein 3