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Members of the G protein-coupled receptor (GPR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell (Sawzdargo et al., 1999 [PubMed 9931487]).[supplied by OMIM, Apr 2008].. Additionally we are shipping GPR55 Proteins (3) and GPR55 Kits (1) and many more products for this protein.
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We observed a significantly higher expression of GPR55 mRNA in Crohn's disease (CD) patients compared to ulcerative colitis (UC) and controls. CD patients manifested higher GPR55 mRNA expression in inflamed compared with non-inflamed colonic tissues. In contrast, the analysis of GPR55 mRNA expression in UC patients revealed no statistically significant differences between inflamed and non-inflamed colonic tissue.
Crucial amino acid residues involved in agonist signaling at the GPR55 receptor have been identified.
The signalling pathways activated by lysophosphatidylinositol through its receptor GPR55 play a pivotal role in different cancer. [review]
GPR55 is involved in the migratory behaviour of colon carcinoma cells.
Inhibiting the pro-angiogenic L-alpha-lysophosphatidylinositol /GPR55 pathway appears a promising target against angiogenesis in ovarian carcinoma
GPR55 is expressed in placenta,located solely at the placental endothelium; L-alpha-lysophosphatidylinositol (LPI (show Slc7a7 Antibodies)), the endogenous ligand of GPR55, increases migratory activity of venous but not arterial placental endothelial cells suggesting a role of LPI (show Slc7a7 Antibodies)-GPR55 axis in placental venous endothelium function
GPR55 could play deleterious role in ox-LDL-induced foam cells and could be a novel pharmacological target to manage atherosclerosis and other related cardiovascular diseases.
GPR55 was a direct target gene of miR (show MLXIP Antibodies)-675-5p.
expression of CB1 (show CNR1 Antibodies) and GPR55 in proximal tubules is altered in response to elevated levels of glucose and albumin (show ALB Antibodies)
This review summarizes our current knowledge of expression and function of GPR55 in tissues involved in metabolic regulation and the signaling cascades through which GPR55 is reported to act.
GPR55 agonist lysophosphatidylinositol and lysophosphatidylcholine inhibit endothelial cell hyperpolarization via GPR (show ALDH18A1 Antibodies)-independent suppression of Na(+)-Ca(2 (show CA2 Antibodies)+) exchanger and endoplasmic reticulum Ca(2 (show CA2 Antibodies)+) refilling.
Gpr55 deficiency is associated with subtle effects on energy expenditure and motor activity behaviours but does not appear per se critically required for overall metabolism or behaviours
GPR55 has an important role in energy homeostasis. GPR55 ablation increases adiposity and insulin (show INS Antibodies) resistance by selectively decreasing physical activity, but not by altering feeding behavior as CB1 (show CNR1 Antibodies).
Results indicate that GPR55 modulates the growth rate and the targets innervation of retinal projections and highlight, for the first time, an important role of GPR55 in axon refinement during development
Data show evidence of GPR55 involvement in central pain processing and unravel a novel Ca2 (show CA2 Antibodies)+-mediated mechanism by which periaqueductal gray neurons are activated downstream of GPR55.
Mice deficient in GPR55 exhibit maladaptive adrenergic signalling, as evidenced by the reduced contractile reserve.
GPR55 is distributed in pancreatic beta cells and is a strong activator of insulin (show INS Antibodies) secretion, with glucose-lowering effects in vivo. Development of agents agonizing the GPR55 receptor may have therapeutic potential in the treatment of type 2 diabetes.
Data (including data from knockout mice) suggest that GPR55 is strongly expressed on myenteric neurons of the colon and that GPR55 is selectively involved in the regulation of colonic motility.
GPR55 plays a role in motor coordination, but does not strongly regulate CNS development, gross motor movement or several types of learned behavior.
Members of the G protein-coupled receptor (GPR) family, such as GPR55, play important roles in signal transduction from the external environment to the inside of the cell (Sawzdargo et al., 1999
G protein-coupled receptor 55
, G-protein coupled receptor 55