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GDP-Mannose 4,6-Dehydratase Proteins (GMDS)

GDP-mannose 4,6-dehydratase (GMD\; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. Additionally we are shipping GDP-Mannose 4,6-Dehydratase Antibodies (37) and GDP-Mannose 4,6-Dehydratase Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GMDS 218138 Q8K0C9
Rat GMDS GMDS 291095  
GMDS 2762 O60547
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Top GDP-Mannose 4,6-Dehydratase Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cricetulus griseus His tag   1 mg Log in to see 56 to 66 Days
$3,017.67
Details
Yeast Shigella flexneri His tag   1 mg Log in to see 56 to 66 Days
$3,023.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

GMDS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced GDP-Mannose 4,6-Dehydratase Proteins

  1. Human GMDS Protein expressed in Escherichia coli (E. coli) - ABIN667602 : Moriwaki, Noda, Furukawa, Ohshima, Uchiyama, Nakagawa, Taniguchi, Daigo, Nakamura, Hayashi, Miyoshi: Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. in Gastroenterology 2009 (PubMed)
    Show all 2 references for ABIN667602

More Proteins for GDP-Mannose 4,6-Dehydratase (GMDS) Interaction Partners

Human GDP-Mannose 4,6-Dehydratase (GMDS) interaction partners

  1. Disruptions of enhancers near FOXC1 (show FOXC1 Proteins) and GMDS may influence brain development.

  2. Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1 (show ABCA1 Proteins)), within actin filament associated protein 1 (AFAP1 (show AFAP1 Proteins)) and within GDP-mannose 46-dehydratase (GMDS).

  3. These data demonstrate involvement of GMDS mutation in the progression of colorectal cancer.

  4. Fx enzyme and GDP-L-Fuc (show FUT8 Proteins) Tr overexpression in the tumur tissue of colorectal cancer (CRC (show CALR Proteins)) patients suggests that GDP-L-Fuc (show FUT8 Proteins) transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC (show CALR Proteins).

  5. GMD inhibits tankyrase 1 (show TNKS Proteins) poly(ADP-ribose) polymerase (show PARP1 Proteins) activity in vitro, dependent on the GMD tankyrase 1 (show TNKS Proteins) binding motif. In vivo, depletion of GMD led to degradation of tankyrase 1 (show TNKS Proteins), dependent on the catalytic PARP activity of tankyrase 1 (show TNKS Proteins).

  6. Results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors.

  7. Deficiency of GMDS leads to escape from natural killer cell-mediated tumor surveillance through modulation of TRAIL signaling.

GDP-Mannose 4,6-Dehydratase (GMDS) Protein Profile

Protein Summary

GDP-mannose 4,6-dehydratase (GMD\; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).

Gene names and symbols associated with GMDS

  • GDP-mannose 4, 6-dehydratase (Gmds)
  • GDP-mannose 4,6-dehydratase (GMDS)
  • BC031788 protein
  • C87208 protein
  • GMD protein
  • SDR3E1 protein

Protein level used designations for GMDS

GDP-D-mannose dehydratase , GDP-mannose 4,6 dehydratase , GMD , short chain dehydrogenase/reductase family 3E, member 1

GENE ID SPECIES
218138 Mus musculus
291095 Rattus norvegicus
2762 Homo sapiens
420890 Gallus gallus
488189 Canis lupus familiaris
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