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GDP-mannose 4,6-dehydratase (GMD\; EC 126.96.36.199) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. Additionally we are shipping GDP-Mannose 4,6-Dehydratase Antibodies (38) and GDP-Mannose 4,6-Dehydratase Kits (2) and many more products for this protein.
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Human GMDS Protein expressed in Escherichia coli (E. coli) - ABIN667602
Moriwaki, Noda, Furukawa, Ohshima, Uchiyama, Nakagawa, Taniguchi, Daigo, Nakamura, Hayashi, Miyoshi: Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. in Gastroenterology 2009
Show all 2 references for ABIN667602
Disruptions of enhancers near FOXC1 (show FOXC1 Proteins) and GMDS may influence brain development.
Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1 (show ABCA1 Proteins)), within actin filament associated protein 1 (AFAP1 (show AFAP1 Proteins)) and within GDP-mannose 46-dehydratase (GMDS).
These data demonstrate involvement of GMDS mutation in the progression of colorectal cancer.
Fx enzyme and GDP-L-Fuc (show FUT8 Proteins) Tr overexpression in the tumur tissue of colorectal cancer (CRC (show CALR Proteins)) patients suggests that GDP-L-Fuc (show FUT8 Proteins) transport to the Golgi apparatus may be an important factor associated with increased alpha(1,6)fucosylation in CRC (show CALR Proteins).
GMD inhibits tankyrase 1 (show TNKS Proteins) poly(ADP-ribose) polymerase (show PARP1 Proteins) activity in vitro, dependent on the GMD tankyrase 1 (show TNKS Proteins) binding motif. In vivo, depletion of GMD led to degradation of tankyrase 1 (show TNKS Proteins), dependent on the catalytic PARP activity of tankyrase 1 (show TNKS Proteins).
Results indicate that GMDS regulates the formation of secondary complex II from the primary DISC independent of direct fucosylation of death receptors.
Deficiency of GMDS leads to escape from natural killer cell-mediated tumor surveillance through modulation of TRAIL signaling.
GDP-mannose 4,6-dehydratase (GMD\; EC 188.8.131.52) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).
, GDP-mannose 4,6 dehydratase
, short chain dehydrogenase/reductase family 3E, member 1