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GTF2I Repeat Domain Containing 1 Proteins (GTF2IRD1)

The protein encoded by GTF2IRD1 contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. Additionally we are shipping GTF2I Repeat Domain Containing 1 Antibodies (93) and GTF2I Repeat Domain Containing 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GTF2IRD1 57080 Q9JI57
GTF2IRD1 9569 Q9UHL9
Rat GTF2IRD1 GTF2IRD1 246770  
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Top GTF2I Repeat Domain Containing 1 Proteins at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

GTF2IRD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for GTF2I Repeat Domain Containing 1 (GTF2IRD1) Interaction Partners

Mouse (Murine) GTF2I Repeat Domain Containing 1 (GTF2IRD1) interaction partners

  1. Gtf2ird1 is essential for Mkx (show MKX Proteins) transcription, while also linking mechanical forces to Mkx (show MKX Proteins)-mediated tendon homeostasis and regeneration.

  2. Gtf2ird1 is expressed in a number of cell types within the cochlea. Gtf2ird1 null mice showed higher auditory thresholds.

  3. findings suggest an important role for GTF2IRD1 in regulating the level and topology of rod and cone gene expression, and in maintaining normal retinal function.

  4. GTF2IRD2 (show GTF2IRD2 Proteins) has evolved as a regulator of GTF2IRD1 and TFII-I (show GTF2I Proteins); inhibiting their function by direct interaction and sequestration into inactive nuclear zones.

  5. This study presented that role for GTF2IRD1 in the motoric and anxiety-related abnormalities seen in Williams-Beuren syndrome, and suggests basal ganglia and potentially cerebellar abnormalities in Gtf2ird1 mice.

  6. Widespread and robust expression of Gtf2ird1 protein in the developing rodent brain, is reported.

  7. Data show the existence of a negative autoregulatory mechanism that controls the level of GTF2IRD1 transcription via direct binding of the GTF2IRD1 protein to a highly conserved region of the GTF2IRD1 promoter containing an array of three binding sites.

  8. The presence of different domains in 11 alternatively spliced isoforms of Gtf2ird1 indicates that the activity exerted by this molecule influences multiple promoters active in mouse skeletal muscle.

  9. TFII-I (show GTF2I Proteins) (Mus (show TRPV6 Proteins)-TRD1) has a role in regulating immunoglobulin promoter activity

  10. First systematic and unbiased analysis of individual GTF2I (show GTF2I Proteins)-like repeats with regard to DNA binding

Human GTF2I Repeat Domain Containing 1 (GTF2IRD1) interaction partners

  1. Study demonstrates a significant association between SLE in Chinese Han population and the GTF2I (show GTF2I Proteins) rs117026326 T allele/GTF2IRD1 rs4717901 C allele.

  2. GTF2IRD1 binding partners are mostly involved in chromatin modification and transcriptional regulation, whilst others indicate an unexpected role in connection with the primary cilium.

  3. GTF2IRD1 is SUMOylated by the SUMO E2 ligase UBC9 (show UBE2I Proteins) and the level of SUMOylation is enhanced by PIASxbeta (show PIAS2 Proteins).

  4. CLIP2 (show CLIP2 Proteins) haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome; GTF2IRD1 and GTF2I (show GTF2I Proteins) are the main genes causing the cognitive defects

  5. This study provided evidences that insufficiency of GTF2IRD1 protein contributes to abnormalities of facial development, motor function and specific behavioural disorders that accompany Williams-Beuren syndrome.

  6. functional hemizygosity for the GTF2I (show GTF2I Proteins) and GTF2IRD1 genes is the main cause of the neurocognitive profile and some aspects of the gestalt phenotype of Williams-Beuren syndrome

  7. Data show the existence of a negative autoregulatory mechanism that controls the level of GTF2IRD1 transcription via direct binding of the GTF2IRD1 protein to a highly conserved region of the GTF2IRD1 promoter containing an array of three binding sites.

  8. characterization and involvement in slow muscle-specific (show EIF3K Proteins) gene expression

  9. role as a repressor of slow fiber-specific transcription through mechanisms involving direct interactions with MEF2C (show MEF2C Proteins) and the nuclear receptor co-repressor

  10. GTF2IRD1 and GTF2I (show GTF2I Proteins) have roles in causing deficits on visual spatial functioning

Cow (Bovine) GTF2I Repeat Domain Containing 1 (GTF2IRD1) interaction partners

  1. cGMP-dependent protein kinase (show CDK7 Proteins) Ibeta binds to TFII-I (show GTF2I Proteins) and IRAG (show MRVI1 Proteins) through a common interaction motif

GTF2I Repeat Domain Containing 1 (GTF2IRD1) Protein Profile

Protein Summary

The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with GTF2IRD1

  • GTF2I repeat domain-containing 1 (gtf2ird1)
  • GTF2I repeat domain containing 1 (GTF2IRD1)
  • general transcription factor II I repeat domain-containing 1 (Gtf2ird1)
  • GTF2I repeat domain containing 1 (Gtf2ird1)
  • GTF2I repeat domain containing 1 (gtf2ird1)
  • 1700012P16Rik protein
  • BEN protein
  • cream1 protein
  • ESTM9 protein
  • Gtf2il protein
  • GTF2IRD1 protein
  • gtf3 protein
  • hMusTRD1alpha1 protein
  • mustrd1 protein
  • rbap2 protein
  • Tg(Alb1-Myc)166.8Sst protein
  • wbs protein
  • wbscr11 protein
  • wbscr12 protein
  • X83320 protein
  • XBEN protein
  • XWBSCR11 protein

Protein level used designations for GTF2IRD1

GTF2I repeat domain-containing 1 , GTF2I repeat domain containing 1 , general transcription factor II-I repeat domain-containing protein 1 , general transcription factor II-I repeat domain-containing protein 1-like , Alb-c-myc line 166.8 , Alb/c-myc line 166.8 , GTF2I repeat domain-containing protein 1 , Williams-Beuren syndrome chromosome region 11 , binding factor for early enhancer , c-myc line 166.8 , general transcription factor 3 , muscle TFII-I repeat domain-containing protein 1 , transcription factor GTF3 alpha 2 , transcription factor GTF3 gamma 2 , USE B1-binding protein , general transcription factor III , muscle TFII-I repeat domain-containing protein 1 alpha 1 , slow-muscle-fiber enhancer-binding protein , williams-Beuren syndrome chromosomal region 12 protein , general transcription factor II I repeat domain-containing 1 , Binding factor for early enhancer , Williams-Beuren syndrome critical region 11-like protein

GENE ID SPECIES
81597 Danio rerio
463471 Pan troglodytes
693935 Macaca mulatta
100461122 Pongo abelii
100473117 Ailuropoda melanoleuca
100510956 Sus scrofa
57080 Mus musculus
9569 Homo sapiens
489796 Canis lupus familiaris
246770 Rattus norvegicus
398320 Xenopus laevis
417487 Gallus gallus
507792 Bos taurus
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