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GTP Cyclohydrolase I Feedback Regulator Proteins (GCHFR)

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. Additionally we are shipping GCHFR Antibodies (54) and GCHFR Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GCHFR 2644 P30047
GCHFR 320415 P99025
GCHFR 171128 P70552
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Top GCHFR Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,123.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,123.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,124.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

GCHFR Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for GTP Cyclohydrolase I Feedback Regulator (GCHFR) Interaction Partners

Human GTP Cyclohydrolase I Feedback Regulator (GCHFR) interaction partners

  1. homozygous individuals for the TT haplotype were less likely to respond to the SSRI fluoxetine than to the nortriptyline suggesting a biological process through which GCHFR promoter variants might influence antidepressant response.

  2. Studies provide a new mechanism for regulation of endothelial GTPCH-1 (show GCH1 Proteins) by its phosphorylation and interplay with GFRP.

  3. Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein

  4. allosteric regulation of GTPCH-I activity in the cardiovascular system maybe an important mechanism regulating BH4 levels through GTPCH-I feedback regulatory protein signaling

  5. GFRP/GTPCHI (show GCH1 Proteins) axis functions in epidermal keratinocytes and melanocytes in the cytosol and nucleus.

  6. GCH1 (show GCH1 Proteins) mutations in Japanese patients with DYT5 (show GCH1 Proteins) dystonia. In some of them, the GCH1 (show GCH1 Proteins) enzyme activity was proved to be impaired.

  7. The co-expression of GTP cyclohydrolase I (show GCH1 Proteins) (GCHI) with tyrosine hydroxylase (TH (show TH Proteins)) indicates that TH is indeed active in human neurosecretory neurons.

  8. Demonstrate role for GFRP in regulating iNOS (show NOS2 Proteins)-mediated NO synthesis and suggest that the allosteric regulation of GTP (show AK3 Proteins)-CH1 activity by GFRP may be an important mechanism regulating BH(4) and NO levels in vivo.

  9. 6BH(4) de novo synthesis is controlled by H(2)O(2) in a concentration-dependent manner, but H(2)O(2)-mediated oxidation does not affect the functionality of the GTPCHI (show GCH1 Proteins)/GFRP complex.

Mouse (Murine) GTP Cyclohydrolase I Feedback Regulator (GCHFR) interaction partners

  1. Studies provide a new mechanism for regulation of endothelial GTPCH-1 (show GCH1 Proteins) by its phosphorylation and interplay with GFRP (show NR4A1 Proteins).

  2. GTPCH (show GCH1 Proteins) expression is the primary regulator of BH4 levels, and changes in GTPCH (show GCH1 Proteins) or BH4 are not necessarily accompanied by changes in GFRP (show NR4A1 Proteins) expression.

GCHFR Protein Profile

Protein Summary

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

Gene names and symbols associated with GCHFR

  • GTP cyclohydrolase I feedback regulator (LOC100220034)
  • GTP cyclohydrolase I feedback regulator (GCHFR)
  • GTP cyclohydrolase I feedback regulator (Gchfr)
  • 2010323F13Rik protein
  • GFRP protein
  • HsT16933 protein
  • P35 protein

Protein level used designations for GCHFR

GTP cyclohydrolase I feedback regulator , GTP cyclohydrolase 1 feedback regulatory protein , GTP cyclohydrolase I feedback regulatory protein , GFRP , p35

GENE ID SPECIES
100220034 Taeniopygia guttata
2644 Homo sapiens
617650 Bos taurus
320415 Mus musculus
171128 Rattus norvegicus
423003 Gallus gallus
100153745 Sus scrofa
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