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anti-Galactosidase, alpha (GLA) Antibodies

GLA encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. Additionally we are shipping GLA Kits (37) and GLA Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GLA 2717 P06280
GLA 363494  
GLA 11605  
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Top anti-GLA Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-GLA Antibody Titration: 0.2-1 ug/mlPositive Control: Human brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB GLA Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GLA Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of GLA antibody (N-term) in Hela cell line lysates (35 µg/lane). GLA (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of GLA antibody (N-term) (ABIN390687) in Hela cell line lysates (35 µg/lane). GLA (arrow) was detected using the purified polyclonal antibody. GLA Antibody (N-term) (ABIN390687) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, IHC (p), WB WB Image Galactosidase alpha antibody [N1C2] detects Galactosidase alpha protein by western blot analysis. Rat tissue extracts (50 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Galactosidase alpha antibody [N1C2] , diluted at 1:1000. WB Image Galactosidase alpha antibody detects Galactosidase alpha protein by western blot analysis. Whole cell extracts (30 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with Galactosidase alpha antibody , at a dilution of 1:1000. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-Galactosidase alpha Polyclonal Antibody, Unconjugated (ABIN872875) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Lane 1: mouse liver lysates Lane 2: human colon carcinoma lysates probed with Anti Galactosidase alpha Polyclonal Antibody, Unconjugated (ABIN872875) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 44kD. Observed band size: 44kD. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IP, IHC (p), ELISA, WB Immunochemical staining of human GLA in human breast carcinoma (from 2 donors) with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human GLA in human prostatic carcinoma with rabbit polyclonal antibody(1µg/mL, formalin-fixed paraffin embedded sections). 100 μg Log in to see 16 Days
$308.00
Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 16 Days
$308.00
Details
Human Rabbit Un-conjugated WB GLA antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$510.36
Details
Human Mouse Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$258.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$347.60
Details

GLA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-GLA Antibodies

  1. Human Polyclonal GLA Primary Antibody for EIA, WB - ABIN453055 : Ioannou, Zeidner, Grace, Desnick: Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility. in The Biochemical journal 1998 (PubMed)
    Show all 2 references for ABIN453055

  2. Chicken Polyclonal GLA Primary Antibody for WB - ABIN2785641 : Auray-Blais, Cyr, Ntwari, West, Cox-Brinkman, Bichet, Germain, Laframboise, Melançon, Stockley, Clarke, Drouin: Urinary globotriaosylceramide excretion correlates with the genotype in children and adults with Fabry disease. in Molecular genetics and metabolism 2008 (PubMed)

More Antibodies against GLA Interaction Partners

Human Galactosidase, alpha (GLA) interaction partners

  1. We conclude that a mild GLA (show NAT8 Antibodies) variant is typically characterized by high residual enzyme activity and normal biomarker levels. We found evidence that these variants can still be classified as a distinctive, but milder, sub-type of FD.

  2. Fabry disease, an X-linked disorder of glycosphingolipids that is caused by mutations of the GLA (show NAT8 Antibodies) gene that codes for alpha-galactosidase A, leads to dysfunction of many cell types and includes a systemic vasculopathy.

  3. Study describes 5 novel mutations found in the GLA (show NAT8 Antibodies) gene of patients with clinical diagnosis of Fabry disease.

  4. GLA (show NAT8 Antibodies) gene variations correlate with globotriaosylceramide and globotriaosylsphingosine analog levels in urine and plasma

  5. results directly implicated the GLA (show NAT8 Antibodies) mutation p.E66Q as the genetic etiology of the Chinese renal variant FD pedigree.

  6. This study indicated that the p.E66Q variant of GLA (show NAT8 Antibodies) does not affect the progression of chronic kidney disease.

  7. Thus, inheritance of the CIH caused an mRNA deregulation altering the GLA (show NAT8 Antibodies) expression pattern, producing a tissue glycolipid storage.

  8. data strongly suggest that the GLA (show NAT8 Antibodies) p.(Arg118Cys) variant does not segregate with Fabry disease clinical phenotypes in a Mendelian fashion, but might be a modulator of the multifactorial risk of cerebrovascular disease

  9. In Fabry disease patients, the alpha-galactosidase A-10T allele appears to be causal for neurological manifestations.

  10. Some clinical cases of some members of a Sicilian family to express phenotypical variability of Anderson-Fabry disease in subjects with the same genetic mutation in alpha galactosidase A gene, are reported.

Mouse (Murine) Galactosidase, alpha (GLA) interaction partners

  1. In oocyte meiosis, GM130 (show GOLGA2 Antibodies) localization and expression patterns are regulated by FMNL1 (show FMNL1 Antibodies).

  2. The histological changes in Gla KO mice better resemble the type 2 later-onset phenotype observed in patients with residual alpha-galactosidase A activity.

  3. our findings imply that the alpha-GalA KO mouse is a good model in which to study the peripheral small fiber neuropathy exhibited by FD patients

  4. we demonstrate an age-dependent microvasculopathy of the mesenteric artery in a murine model of Fabry disease (galactosidase A-knockout mice) resulting from dysregulation of the vascular homeostatic enzyme endothelial nitric oxide synthase (eNOS (show NOS3 Antibodies))

  5. GM130 (show GOLGA2 Antibodies) regulates microtubule organization and might cooperate with the MAPK (show MAPK1 Antibodies) pathway to play roles in spindle organization, migration and asymmetric division during mouse oocyte maturation

  6. It suggested that there could be a combination of GLA deficiency and FVL (show F5 Antibodies) or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis.

  7. present Toll (show TLR4 Antibodies)-like receptor-dependent negative regulation of alpha-Gal-A as a mechanistic link between pathogen recognition and self lipid antigen induction for natural killer T cells

  8. Developed a novel recombinant lentiviral vector that engineers expression of alpha-galactosidase. Analysis of tissues at 26 wks demonstrated similar alpha-gal A enzyme activities but enhanced Gb3 reduction in hearts and kidneys compared with control.

  9. alpha-galactosidase A deficiency could be an important genetic modifier for the enhanced thrombosis associated with FV Leiden associated thrombosis.

  10. The adeno (show ADORA2A Antibodies)-associated virus (AAV) vector containing the alpha-gal A gene was injected into the right quadriceps muscles of Fabry knockout mice.

GLA Antigen Profile

Protein Summary

This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Gene names and symbols associated with GLA

  • galactosidase, alpha (GLA) antibody
  • galactosidase, alpha (gla) antibody
  • alpha-galactosidase (agaN) antibody
  • aga (aga) antibody
  • alpha-galactosidase (agaL) antibody
  • alpha-galactosidase (SCO0541) antibody
  • alpha-galactosidase (rafA) antibody
  • alpha-galactosidase (melA) antibody
  • Alpha-galactosidase (galA) antibody
  • alpha-galactosidase A (ANI_1_2528074) antibody
  • alpha-galactosidase A (ANI_1_1502124) antibody
  • alpha-galactosidase A (AOR_1_390174) antibody
  • alpha-galactosidase A (CpipJ_CPIJ002066) antibody
  • alpha-galactosidase (aga) antibody
  • alpha-galactosidase A (MCYG_00962) antibody
  • alpha-galactosidase A (MCYG_00791) antibody
  • alpha-galactosidase (gla) antibody
  • alpha-galactosidase A (Tsp_02909) antibody
  • alpha-galactosidase A (Tsp_02508) antibody
  • galactosidase, alpha (Gla) antibody
  • golgi autoantigen, golgin subfamily a, 2 (Golga2) antibody
  • Ags antibody
  • alpha-GAL antibody
  • AO090005000217 antibody
  • AW555139 antibody
  • GALA antibody
  • GM130 antibody
  • MGC130872 antibody
  • mKIAA4150 antibody
  • SCF11.21 antibody
  • SMU.877 antibody
  • zgc:101584 antibody

Protein level used designations for GLA

galactosidase, alpha , galactosidase alpha , Alpha-galactosidase A , alpha-D-galactosidase A , alpha-galactosidase A-like , alpha-galactosidase , Alpha-galactosidase , alpha-galactosidase A , agalsidase alfa , alpha-D-galactoside galactohydrolase 1 , alpha-gal A , melibiase , alpha-D-galactoside galactohydrolase , 130 kDa cis-Golgi matrix protein , Golgin subfamily A member 2 , SY11 protein , golgin-95

GENE ID SPECIES
280806 Bos taurus
465761 Pan troglodytes
703129 Macaca mulatta
734749 Xenopus laevis
100022779 Monodelphis domestica
100060370 Equus caballus
100145767 Xenopus (Silurana) tropicalis
100409841 Callithrix jacchus
100480888 Ailuropoda melanoleuca
100595113 Nomascus leucogenys
988766 Clostridium perfringens str. 13
1021683 Bifidobacterium longum NCC2705
1028243 Streptococcus mutans UA159
1095964 Streptomyces coelicolor A3(2)
1174420 Yersinia pestis CO92
1255824 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
2956399 Yersinia pseudotuberculosis IP 32953
3977399 Lactobacillus salivarius UCC118
4983447 Aspergillus niger CBS 513.88
4987403 Aspergillus niger CBS 513.88
5989256 Aspergillus oryzae RIB40
6032795 Culex quinquefasciatus
7264928 Bifidobacterium animalis subsp. lactis AD011
9223595 Arthroderma otae CBS 113480
9226616 Arthroderma otae CBS 113480
9450395 Brachyspira pilosicoli 95/1000
10899858 Trichinella spiralis
10903123 Trichinella spiralis
2717 Homo sapiens
363494 Rattus norvegicus
450083 Danio rerio
422188 Gallus gallus
532742 Bos taurus
11605 Mus musculus
100344610 Oryctolagus cuniculus
100718405 Cavia porcellus
407057 Sus scrofa
480988 Canis lupus familiaris
99412 Mus musculus
Selected quality suppliers for anti-GLA (GLA) Antibodies
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