GLA Products
(Galactosidase, alpha (GLA))
Categories
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008].
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Featured GLA Categories
GLA Antibodies
High quality antibodies with extensive validation data.
GLA ELISA Kits
Reliable ELISA kits for a wide range of species.
GLA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended GLA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7431278
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7426817
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, IHC (p)
Validations
- (2)
- (5)
Cat. No.
ABIN2854962
Quantity
100 μL
Datasheet
Datasheet
Recommended GLA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
Cat. No.
ABIN6720556
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN3199196
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4881769
Quantity
96 tests
Datasheet
Datasheet
Recommended GLA Proteins
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1355176
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123037
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7320092
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our GLA products
: "Rapid Clathrin-Mediated Uptake of Recombinant α-Gal-A to Lysosome Activates Autophagy." in: Biomolecules, Vol. 10, Issue 6, (2020) (PubMed).: "Ligand-promoted protein folding by biased kinetic partitioning." in: Nature chemical biology, Vol. 13, Issue 4, pp. 369-371, (2017) (PubMed).
: "Comparison of intracellular and secretion-based strategies for production of human ?-galactosidase A in the filamentous fungus Trichoderma reesei." in: BMC biotechnology, Vol. 14, pp. 91, (2015) (PubMed).
: "Coformulation of a Novel Human α-Galactosidase A With the Pharmacological Chaperone AT1001 Leads to Improved Substrate Reduction in Fabry Mice. ..." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 7, pp. 1169-81, (2015) (PubMed).
: "Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease." in: Kidney international, Vol. 86, Issue 1, pp. 58-66, (2014) (PubMed).
: "A thermodynamic assay to test pharmacological chaperones for Fabry disease." in: Biochimica et biophysica acta, Vol. 1840, Issue 3, pp. 1214-24, (2014) (PubMed).
: "Integrated approach to produce a recombinant, His-tagged human ?-galactosidase A in mammalian cells." in: Biotechnology progress, Vol. 27, Issue 5, pp. 1206-17, (2011) (PubMed).
: "Protein translocation: how Hsp70 pulls it off." in: Cell, Vol. 97, Issue 6, pp. 679-82, (1999) (PubMed).
: "The Hsp70 and Hsp60 chaperone machines." in: Cell, Vol. 92, Issue 3, pp. 351-66, (1998) (PubMed).
: "Expression of hsp70 induced in CHO cells by 45.0 degrees C hyperthermia is cell cycle associated and DNA synthesis dependent." in: Cytometry, Vol. 19, Issue 2, pp. 119-25, (1995) (PubMed).
Synonyms and alternative names related to GLA
galactosidase alpha (GLA), galactosidase, alpha (Gla), galactosidase, alpha (gla), galactosidase alpha S homeolog (gla.S), galactosidase alpha (gla), alpha-galactosidase (agaN), aga (aga), alpha-galactosidase (agaL), alpha-galactosidase (SCO0541), alpha-galactosidase (rafA), alpha-galactosidase (melA), alpha-galactosidase (galA), alpha-galactosidase A (ANI_1_2528074), alpha-galactosidase A (ANI_1_1502124), alpha-galactosidase A (AOR_1_390174), alpha-galactosidase A (CpipJ_CPIJ002066), alpha-galactosidase (aga), alpha-galactosidase A (MCYG_00962), alpha-galactosidase A (MCYG_00791), alpha-galactosidase (gla), alpha-galactosidase A (Tsp_02909), alpha-galactosidase A (Tsp_02508), galactosidase alpha (Gla), galactosidase, alpha (GLA), Ags, alpha-GAL, AO090005000217, GALA, MGC130872, SCF11.21, SMU.877, zgc:101584Protein level used designations for GLA
- agalsidase alfa
- alpha-D-galactosidase A
- alpha-D-galactoside galactohydrolase 1
- alpha-gal A
- alpha-galactosidase A
- melibiase
- alpha-D-galactoside galactohydrolase
- Alpha-galactosidase A
- galactosidase, alpha
- alpha-galactosidase A-like
- alpha-galactosidase
- Alpha-galactosidase
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