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General Transcription Factor III Proteins (GTF2I)

GTF2I encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. Additionally we are shipping GTF2I Antibodies (111) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GTF2I 14886 Q9ESZ8
Rat GTF2I GTF2I 353256 Q5U2Y1
GTF2I 2969 P78347
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Top GTF2I Proteins at

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days

GTF2I Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for General Transcription Factor III (GTF2I) Interaction Partners

Mouse (Murine) General Transcription Factor III (GTF2I) interaction partners

  1. found a highly conserved DNA element, common to a set of genes regulated by TFII-I, and identified and validated novel in vivo neuronal targets of this protein affecting the PI3K and TGFbeta (show TGFB1 Proteins) signaling pathways

  2. GTF2IRD2 (show GTF2IRD2 Proteins) has evolved as a regulator of GTF2IRD1 (show GTF2IRD1 Proteins) and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones.

  3. data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation

  4. GTF2I duplication results in separation anxiety in mice and humans

  5. In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice.

  6. Results suggest that DJ-1 (show PARK7 Proteins) together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function.

  7. behavioral characterization of heterozygous mice with a deletion of the first 140 amino-acids of TFII-I.

  8. data demonstrate that TFII-I, through a Src (show SRC Proteins)-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes

  9. acts as a transcriptional cofactor for the SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 (show PIAS2 Proteins)

  10. TFII-I has a role in regulating immunoglobulin promoter activity

Human General Transcription Factor III (GTF2I) interaction partners

  1. A novel interaction between TFII-I and Mdm2 (show MDM2 Proteins) with a negative effect on TFII-I transcriptional activity has been documented.

  2. Copy-number variation in the general transcription factor gene, GTF2I is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7.

  3. show that SUMOylation is critical for TFII-I to promote cell proliferation and colony formation. Our findings contribute to understanding the role of SUMOylation in liver cancer development

  4. Study demonstrates a significant association between SLE in Chinese Han population and the GTF2I rs117026326 T allele/GTF2IRD1 (show GTF2IRD1 Proteins) rs4717901 C allele.

  5. Rather than contributing positively to promoter activity, a putative initiator element at the transcription start site acts as a target for negative regulation imposed on the L4P promoter of human adenovirus Type 5 by cellular TFII-I.

  6. Findings implicate the GTF2I gene in the neurogenetic basis of social communication and social anxiety, both in Williams syndrome and among individuals in healthy populations

  7. TFII-I bridges Proliferating Cell Nuclear Antigen (show PCNA Proteins) and Polzeta to promote Translesion synthesis

  8. The GTF2I rs117026326 polymorphism is associated with anti-SSA (show TRIM21 Proteins)-positive primary Sjogren's syndrome.

  9. A proportion of this transcriptional dysregulation is caused by dosage imbalances in GTF2I, which encodes a key transcription factor at 7q11.23 that is associated with the LSD1 (show KDM1A Proteins) repressive chromatin complex and silences its dosage-sensitive targets.

  10. GTF2I mutation correlated with better survival.

GTF2I Protein Profile

Protein Summary

This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.

Gene names and symbols associated with GTF2I

  • general transcription factor IIi (gtf2i)
  • general transcription factor II I (Gtf2i)
  • general transcription factor IIi (GTF2I)
  • 6030441I21Rik protein
  • BAP-135 protein
  • BAP135 protein
  • BTKAP1 protein
  • DIWS protein
  • Gtf2ird1 protein
  • GTFII-I protein
  • IB291 protein
  • SPIN protein
  • TFII-I protein
  • WBS protein
  • WBSCR6 protein

Protein level used designations for GTF2I

BTK-associated protein 135 , Bruton tyrosine kinase-associated protein 135 , general transcription factor II-I , GTFII-I , TFII-I , BTK-associated protein, 135kD , SRF-Phox1-interacting protein , Williams-Beuren syndrome chromosome region 6 , general transcription factor II, i

549986 Xenopus (Silurana) tropicalis
14886 Mus musculus
353256 Rattus norvegicus
2969 Homo sapiens
417486 Gallus gallus
479714 Canis lupus familiaris
534669 Bos taurus
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