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Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Additionally we are shipping GANAB Proteins (7) and GANAB Kits (1) and many more products for this protein.
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Human Polyclonal GANAB Primary Antibody for ELISA, WB - ABIN1535109
Pelletier, Marcil, Sevigny, Jakob, Tessier, Chevet, Menard, Bergeron, Thomas: The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. in Glycobiology 2000
Show all 2 references for 1535109
used whole exome sequencing in a discovery cohort of 102 unrelated patients who were excluded for mutations in the 2 most common polycystic liver disease genes, PRKCSH (show PRKCSH Antibodies) and SEC63 (show SEC63 Antibodies), to identify heterozygous loss-of-function mutations in 3 additional genes, ALG8 (show ALG8 Antibodies), GANAB, and SEC61B (show SEC61B Antibodies). Similarly to PRKCSH (show PRKCSH Antibodies) and SEC63 (show SEC63 Antibodies), these genes encode proteins that are integral to the protein biogenesis pathway in the endoplasmic reticulum.
Mutations in GANAB gene is associated with Autosomal-Dominant Polycystic Kidney and Liver Disease.
Loss of the tumor suppression function of Hsp60 (show HSPD1 Antibodies) or GANAB contribute to aggressive cancers.
In males being treated for infertility, neutral alpha-glucosidase (show AGLU Antibodies) activity correlated with the percentage of sperm DNA fragmentation.
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.
alpha glucosidase II alpha subunit
, neutral alpha-glucosidase AB
, glucosidase, alpha; neutral AB
, neutral alpha-glucosidase AB-like
, alpha-glucosidase 2
, carbohydrate processing enzyme of the endoplasmic reticulum
, glucosidase II alpha-subunit
, glucosidase II subunit alpha
, alpha glucosidase 2 alpha neutral subunit
, neutral AB