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Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a Proteins (GRIN2A)

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. Additionally we are shipping NMDAR2A Antibodies (225) and NMDAR2A Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRIN2A 2903 Q12879
Rat GRIN2A GRIN2A 24409 Q00959
GRIN2A 14811 P35436
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Top NMDAR2A Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 9 to 11 Days
$756.80
Details

GRIN2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) Interaction Partners

Human Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) interaction partners

  1. To determine genetic variability within the N-methyl-D-aspartate receptor 2A sub-unit (GRIN2A) gene promoter and its association with concussion recovery time.

  2. Knockdown of PKD1 (show PKD1 Proteins) did not affect NMDAR (show GRIN1 Proteins) internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR (show GRIN1 Proteins)-mediated synaptic functions.

  3. Findings suggest that mutations in GRIN2A preferentially are involved in genetic variance of pediatric idiopathic generalized epilepsy and do not contribute significantly to either adult focal epilepsies as temporal lobe epilepsy or generalized epilepsies

  4. Based on large, well-characterized datasets independent from the original study, our results are not in favor of an interaction between caffeinated coffee consumption and GRIN2A rs4998386 for Parkinson disease risk

  5. Study found GluN receptor subunit-specific changes in mixed subcortical ischemic vascular dementia(SIVD)/Alzheimer's disease(AD) (decreased GluN1 (show GRIN1 Proteins)) and SIVD (increased GluN2A and 2B), likely reflecting interaction of ischemic neurovascular and AD processes

  6. NMDARs have a dual role during erythropoiesis, supporting survival of polychromatic erythroblasts and contributing to the Ca(2 (show CA2 Proteins)+) homeostasis from the orthochromatic erythroblast stage to circulating red blood cells.

  7. GRIN2A (GT)21 may play a significant role in the etiology of schizophrenia among the Chinese Han population of Shaanxi.

  8. GRIN2A gene polymorphisms confer susceptibility to heroin addiction.

  9. Dysarthria and dyspraxia are found in individuals with GRIN2A mutations, often in the setting of epilepsy-aphasia syndromes. The speech phenotype may occur in the absence of a seizure disorder, reinforcing the role for GRIN2A in motor speech function.

  10. We demonstrate the functional importance of GRIN2A mutations in melanoma and the significance that ionotropic glutamate (show GRIN1 Proteins) receptor signaling has in malignant melanoma.

Mouse (Murine) Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A) interaction partners

  1. Rph3A (show RPH3A Proteins) interacts with GluN2A and PSD-95 (show DLG4 Proteins) forming a complex that regulates NMDARs stabilization at postsynaptic membranes.

  2. Egr-1 (show EGR1 Proteins) is involved in NMDAR (show GRIN1 Proteins)-mediated PSD-95 (show DLG4 Proteins) down-regulation and AMPAR endocytosis, a process important in the expression of long term depression

  3. Study demonstrated that GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice

  4. Results establish the GluN2A subunit as a significant contributor to both bidirectional synaptic plasticity and spatial pattern separation in the dentate gyrus

  5. Best1 (show BEST1 Proteins)-mediated astrocytic glutamate (show GRIN1 Proteins) activates the synaptic N-methyl-D-aspartate receptor (show GRIN1 Proteins) (NMDAR (show GRIN1 Proteins)) and modulates NMDAR (show GRIN1 Proteins)-dependent synaptic plasticity.

  6. Data suggest a role for GluN2A in ethanol tolerance.

  7. We conclude that TSPYL2 (show TSPYL2 Proteins) contributes to cognitive variability through regulating the expression of Grin2a and Grin2b (show GRIN2B Proteins).

  8. Results suggest that GluN2B (show GRIN2B Proteins) is essential for the survival of animals, and that the GluN2B (show GRIN2B Proteins)-GluN2A switching plays a critical role in synaptic integration of AMPARs through regulation of GluA1 (show GRIA1 Proteins) in the whole animal.

  9. GluN2A KO mice showed a specific and significant impairment in ventromedial prefrontal cortex-mediated set-shifting.

  10. Deletion of the NMDA receptor GluN2A subunit significantly decreases dendritic growth in maturing dentate granule neurons.

NMDAR2A (GRIN2A) Protein Profile

Protein Summary

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GRIN2A

  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A (grin2a)
  • glutamate receptor ionotropic, NMDA 2A-like (LOC524212)
  • glutamate receptor, ionotropic, N-methyl D-aspartate 2A (Grin2a)
  • glutamate receptor, ionotropic, NMDA2A (epsilon 1) (Grin2a)
  • EPND protein
  • GluN2A protein
  • GRIN2A protein
  • NMDAR2A protein
  • NR2A protein

Protein level used designations for GRIN2A

N-methyl-D-aspartate receptor subunit NR2A , glutamate receptor, ionotropic, N-methyl D-aspartate 2A , glutamate [NMDA] receptor subunit epsilon-1-like , N-methyl D-aspartate receptor subtype 2A , N-methyl-D-aspartate receptor channel, subunit epsilon-1 , N-methyl-D-aspartate receptor subunit 2A , NMDA receptor subtype 2A , glutamate [NMDA] receptor subunit epsilon-1 , glutamate receptor ionotropic, NMDA 2A , hNR2A , glutamate [NMDA] receptor subunit epsilon 1 , glutamate receptor, ionotropic, N-methyl-D-aspartate subunit 2A , GluRepsilon1

GENE ID SPECIES
778440 Taeniopygia guttata
100127346 Xenopus laevis
100411569 Callithrix jacchus
100438553 Pongo abelii
100584731 Nomascus leucogenys
524212 Bos taurus
2903 Homo sapiens
24409 Rattus norvegicus
100727265 Cavia porcellus
490012 Canis lupus familiaris
427678 Gallus gallus
454396 Pan troglodytes
14811 Mus musculus
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