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anti-Glycine Receptor, alpha 1 (GLRA1) Antibodies

The protein encoded by GLRA1 is a subunit of a pentameric inhibitory glycine receptor. Additionally we are shipping GLRA1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GLRA1 25674 P07727
GLRA1 2741 P23415
GLRA1 14654  
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Top anti-GLRA1 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-GLRA1 Antibody Titration: 0.2-1 ug/mlPositive Control: Raji cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated DB, IHC (fro), WB 0.2 mg Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample(30 μg of whole cell lysate) A:HeLa S3, 7.5% SDS PAGE antibody diluted at 1:1500 IHC-P Image Immunohistochemical analysis of paraffin-embedded OVCA xenograft, using Glycine Receptor alpha1, antibody at 1:100 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Cow Goat Un-conjugated WB Staining of Mouse Testis lysate using AP32151PU-N at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IHC (fro), IP, WB   200 μg Log in to see 8 to 10 Days
$727.83
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Dog Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Rat Goat Un-conjugated IHC (p), ELISA, WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Un-conjugated IP, IHC, ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$359.70
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$405.17
Details

GLRA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)
,

Human , , ,
, ,
,
Mouse (Murine)
,

Top referenced anti-GLRA1 Antibodies

  1. Human Polyclonal GLRA1 Primary Antibody for DB, IHC (fro) - ABIN372657 : Craig, Lichtman: Getting a bead on receptor movements. in Nature neuroscience 2001 (PubMed)
    Show all 6 references for ABIN372657

  2. Cow (Bovine) Polyclonal GLRA1 Primary Antibody for WB - ABIN2792243 : Schofield, Trudell, Harrison: Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. in Biochemistry 2004 (PubMed)

More Antibodies against GLRA1 Interaction Partners

Human Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. GLRA1 and GLRB (show GLRB Antibodies) mutations are responsible for abnormal startled reactions in humans. (Review)

  2. in two sisters with hyperekplexia a compound heterozygosis of 2 novel mutations of GLRA1 gene was found - heterozygous for a C-to-G base transition resulting in a phenylalanine to leucine amino acid change in position 235 and for a T-to-C base transition resulting in a cysteine to arginine amino acid change in position 237

  3. the TM3 (show TPM1 Antibodies)-4 loop length is critical for glycine receptor (show GLRB Antibodies) alpha1 desensitization and a direct neighborhood of both basic stretches changes receptor properties from non-desensitizing to desensitizing.

  4. Mutations in the GLRA1 were identified in 16 Japanese patients with hyperekplexia.

  5. The first X-ray structure of the TMD (show TTN Antibodies) of the alpha1GlyR solved here using GLIC as a scaffold paves the way for mechanistic investigation and design of allosteric modulators of a human receptor.

  6. In GlyRA1 mutants, a portion of them can be transported to the plasma membrane but don't form funtional channels; a possible cause for hyperekplexia.

  7. Conformation and function of the human GLRA1 chloride channel (show CLCA1 Antibodies).

  8. Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor (show GLRB Antibodies) activation.

  9. Glycine receptor (show GLRB Antibodies) alpha1 subunit specific-autoantibody study aids identification of autoimmune brainstem/spinal cord hyperexcitability disorders and may extend to the glycinergic visual system.

  10. TM3 (show TPM1 Antibodies)-4 loop subdomains are important for functional reconstitution of glycine receptors by independent domains

Zebrafish Glycine Receptor, alpha 1 (GLRA1) interaction partners

Mouse (Murine) Glycine Receptor, alpha 1 (GLRA1) interaction partners

  1. Mutation of a zinc-binding residue in the glycine receptor (show GLRB Antibodies) alpha1 changes ethanol sensitivity in vitro and alcohol consumption in Glra1(D80A) knock-in mice.

  2. TM3 (show TPM1 Antibodies)-4 loop subdomains are important for functional reconstitution of glycine receptors by independent domains

  3. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, resulted in a small but general impairment of glycine action, that is most evident in the glycine-induced maximal currents.

  4. Mutations in the GlyR alpha-1 subunit, M287L and Q266I, decreased specific behavioral actions of ethanol and altered other nonethanol behaviors, demonstrating the importance of GlyR function in diverse neuronal systems.

  5. The values of breathing frequency, tidal volume, and minute ventilation in newborn Glra1-deficient oscillator mice decrease rapidly during postnatal development.

  6. The new Glra1 mutation appears to affect glycine's inhibitory neurotransmission in the central nervous system (CNS) of the nmf11 homozygotes, which suffer from a severe startle disease-related phenotype and die by postnatal day 21.

  7. Thus, the hyperekplexia phenotype of Glra1(D80A) mice is due to the loss of Zn(2+) potentiation of alpha1 subunit containing GlyRs (show GARS Antibodies), indicating that synaptic Zn(2+) is essential for proper in vivo functioning of glycinergic neurotransmission.

  8. These results show that insulin (show INS Antibodies) has a novel regulatory action on the potency of glycine for ionotropic glycine receptors.

GLRA1 Antigen Profile

Protein Summary

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GLRA1

  • glycine receptor, alpha 1 (GLRA1) antibody
  • glycine receptor subunit alpha-1-like (LOC100513384) antibody
  • glycine receptor, alpha 1 (Glra1) antibody
  • glycine receptor, alpha 1 (glra1) antibody
  • glycine receptor, alpha 1 subunit (Glra1) antibody
  • B230397M16Rik antibody
  • GLYRA1 antibody
  • HKPX1 antibody
  • nmf11 antibody
  • oscillator antibody
  • ot antibody
  • spasmodic antibody
  • spd antibody
  • STHE antibody
  • [a]Z1 antibody

Protein level used designations for GLRA1

glycine receptor, alpha 1 (startle disease/hyperekplexia) , glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) , glycine receptor, alpha 1 , glycine receptor subunit alpha-1-like , glycine receptor 48 kDa subunit , glycine receptor strychnine-binding subunit , glycine receptor subunit alpha-1 , glycine receptor, alpha 1 subunit , GlyR [a]Z1 , glycine receptor subunit alphaZ1 , glycine receptor, alphaZ1 subunit , glycine receptor alpha 1 subunit

GENE ID SPECIES
471712 Pan troglodytes
100446940 Pongo abelii
100473634 Ailuropoda melanoleuca
100546420 Meleagris gallopavo
100513384 Sus scrofa
25674 Rattus norvegicus
2741 Homo sapiens
30676 Danio rerio
489172 Canis lupus familiaris
281783 Bos taurus
427637 Gallus gallus
100060055 Equus caballus
100344552 Oryctolagus cuniculus
14654 Mus musculus
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