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The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. Additionally we are shipping Golgi Membrane Protein 1 Antibodies (169) and Golgi Membrane Protein 1 Kits (37) and many more products for this protein.
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Human GOLM1 Protein expressed in Human Cells - ABIN2005402
Kladney, Bulla, Guo, Mason, Tollefson, Simon, Koutoubi, Fimmel: GP73, a novel Golgi-localized protein upregulated by viral infection. in Gene 2000
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Human GOLM1 Protein expressed in Escherichia coli (E. coli) - ABIN2005400
Kladney, Tollefson, Wold, Fimmel: Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain. in Virology 2002
Show all 4 references for 2005400
Both gain- and loss-of-function studies determine that GOLM1 acts as a key oncogene (show RAB1A Proteins) by promoting HCC (show FAM126A Proteins) growth and metastasis.
A cytokine QTL at the NAA35 (show MAK10 Proteins)-GOLM1 locus markedly modulated interleukin (IL)-6 (show IL6 Proteins) production in response to multiple pathogens and was associated with susceptibility to candidemia.
knock-down of GP73 down-regulates HCV infection and replication in Huh7-MAVSR cells and primary human hepatocytes
Studies indicate that golgi membrane protein 1 (GOLM1) may promote HCC (show FAM126A Proteins) by regulation of epidermal growth factor receptor (EGFR (show EGFR Proteins)) recycling, and suggest that therapeutic targeting of GOLM1 may be a potential strategy for combating hepatocellular carcinoma (HCC (show FAM126A Proteins)) metastasis.
these studies revealed that GP73 promotes hepatitis C virus (HCV) secretion by directly mediating the interaction of ApoE (show APOE Proteins) with HCV replication complex through binding with HCV NS5A.
Significantly higher serum levels of GP-73 and PIVKA-II were detected in the hepatocellular carcinoma patients than in controls.
The critical role of GP73 in hepatocellular carcinoma invasion, epithelial-mesenchymal transition and metastasis
Results show that overexpression of GP73 in hepatocellular carcinoma cell (HCC (show FAM126A Proteins)) line retrieved the expression of epithelial-mesenchymal transition (EMT (show ITK Proteins)) markers, and promoted cell motility and invasion. High expression of GP73 was also found in HCC (show FAM126A Proteins) tissues with metastasis providing evidence for an important role of GP73 in HCC (show FAM126A Proteins) metastasis.
Serum GP73 had limited diagnostic value for HBV-related liver cancer. The combined use of serum GP73 and AFP (show AFP Proteins) levels improved the diagnostic efficacy.
GP73 enhances MMP-13 (show MMP13 Proteins) expression through cAMP responsive element binding protein (CREB (show CREB1 Proteins))-mediated transcription activation. Levels of GP73 and MMP-13 (show MMP13 Proteins) are increased and positively correlated in human HCC (show FAM126A Proteins) tissues. Augmented MMP-13 (show MMP13 Proteins) potentiates HCC (show FAM126A Proteins) cell metastasis.
Gorasp2-/- mice suffered from spermatogenesis defects. Golgi morphology of spermatocytes was disturbed in Gorasp2-/- mice. GRASP55 interacted via PDZ-mediated interactions with JAMs.
GRASP55 (show GORASP2 Proteins) responds to inflammasome stimulation,controls autophagy initiation and important for secretion of IL-1b (show IL1B Proteins) and IL-18 (show IL18 Proteins)
In Atp7b (show ATP7B Proteins)(-/-) mice, GP73 mRNA was significantly elevated at 20-46 weeks of age, coincident with extensive hepatic inflammation and fibrosis.
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene.
golgi membrane protein 1
, golgi phosphoprotein 2
, Golgi membrane protein 1
, golgi membrane protein GP73
, golgi protein, 73-kD
, Golgi reassembly-stacking protein 2
, golgi reassembly-stacking protein of 55 kDa