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GGA2 encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. Additionally we are shipping Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 2 Antibodies (41) and many more products for this protein.
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GGA2 binds to the internal DXXLL motif of the LRP9 (show LRP10 Proteins)
These data indicate that clathrin is required for the function of AP-1 (show FOSB Proteins)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
GGA2 mediates a vital function that cannot be compensated for by GGA1and/or GGA3 (show GGA3 Proteins).
endocytosis and intracellular transport of memapsin 2 (show BACE Proteins), mediated by its cytosolic domain, may involve the binding of GGA1 (show GGA1 Proteins) and GGA2
Results demonstrate that cargo proteins contribute to the recruitment of GGA2 onto membranes and to the formation of GGA-positive clathrin-coated vesicles.
p56 (show IFIT1 Proteins) tightly cooperates with the GGAs in the sorting of cathepsin D (show CTSD Proteins) to lysosomes, probably by enabling the movement of GGA-containing transport carriers.
GGA2 is recruited to the trans-Golgi network independently of the other Golgi-localized, gamma-ear-containing, ARF-binding proteins and is required for the efficient sorting of lysosomal enzymes
GGA overexpression causes various sorting defects as measured by recycling of CD-MPR, internalization of transferrin receptor, and the subcellular localization of proteins like Tsg101, ubiquitin, and Hrs.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.
ADP-ribosylation factor-binding protein GGA2
, gamma-adaptin-related protein 2
, golgi-localized, gamma ear-containing, ARF-binding protein 2
, VHS domain and ear domain of gamma-adaptin
, VHS domain and ear domain-containing protein
, golgi associated, gamma adaptin ear containing, ARF binding protein 2