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Gonadotropin-Releasing Hormone Receptor Proteins (GNRHR)

GNRHR encodes the receptor for type 1 gonadotropin-releasing hormone. Additionally we are shipping GNRHR Antibodies (104) and GNRHR Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNRHR 14715 Q01776
Rat GNRHR GNRHR 81668 P30969
GNRHR 2798 P30968
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Top GNRHR Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
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GNRHR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Gonadotropin-Releasing Hormone Receptor (GNRHR) Interaction Partners

Rabbit Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. These results suggest that GNRHR-I is constitutively expressed in rabbit corpora lutea independently of luteal stage of pseudopregnant rabbits.

Rainbow Trout (Oncorhynchus mykiss) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. Data show that GnRH (show GNRH1 Proteins) stimulates phagocytosis in fish leucocytes through a GnRH-receptor-dependent pathway.

Fruit Fly (Drosophila melanogaster) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. Loss of ppk28 increased neuronal glucagon (show GCG Proteins)-like adipokinetic hormone (AKH (show VIT Proteins)) signaling, and the AKH receptor was necessary for ppk28 mutant effects.

  2. characterization of adipokinetic hormone receptor in insects

  3. mutation of the Drosophila adipokinetic hormone receptor (AKHR), a functional analog of the mammalian glucagon receptor (show GCGR Proteins), leads to abnormal accumulation of both lipid and carbohydrate.

Mouse (Murine) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. His305 of the GnRH receptor forms two distinct interactions that determine binding to GnRH and couple agonist binding to the conserved transmembrane domain network that activates GPCRs.

  2. The aims of this study were to explore whether mRNA-levels of gonadotropin-releasing hormone (Gnrh (show GNRH1 Proteins)) and its receptor (Gnrhr) were changed in plaque-bearing Alzheimer's disease transgenic mice.

  3. Data confirm that Gnrhr mRNA and protein are expressed in ovaries, granulosa cells, cumulus cells, and oocytes.

  4. Msx1 (show MSX1 Proteins) functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU (show CGA Proteins) and GnRHR genes.

  5. These results suggest decreased GnRH receptor signaling in the mutant animal, compared with wild type.

  6. Report down-regulation of ErbB4 (show ERBB4 Proteins) expression in hypothalamic neurons induced by G-protein-coupled gonadotropin releasing hormone receptor stimulation.

  7. GnRHR neurons were found in different brain areas. Many GnRHR neurons were identified in areas influencing sexual behaviors

  8. A comprehensive knowledgebase of the GnRHR signaling in the LbetaT2 cell, was curated.

  9. Null Gnrhr mice had small sexual organs, low levels of FSH, LH, and steroid hormones, failure of sexual maturation, infertility, and inability to respond to exogenous GnRH.

  10. GnRH (show GNRH1 Proteins) and dex synergistically activate the endogenous GnRHR promoter in L beta T2 cells

Human Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. GnRH receptors on triple negative breast cancer cells can be used for targeted therapy of these cancers with GnRH agonist triptorelin

  2. study found a novel mutation in PROK2 (show PROK2 Proteins) in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance

  3. Data suggest differences in regulation of expression of PEDF (show SERPINF1 Proteins) (up-regulation) vs. VEGF (show VEGFA Proteins) (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH (show GNRH1 Proteins)/GNRHR agonists rather than hCG (show CGA Proteins).

  4. A high prevalence of endometriosis, polymorphism in the LHCGR and GnRH1 and progonadoliberin-2 antibodies in serum was found among the patients with severe dysmotility after treatment with GnRH analogs.

  5. No abnormalities were found in the patient group for the PROKR2 (show PROKR2 Proteins) and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes

  6. Mutations were found in the following genes in one or more patients with congenital hypogonadotropic hypogonadism: KAL1, FGFR1, GNRHR, and CHD7

  7. Mutations in GNRHR do not appear to be involved in the pathogenesis of constitutional delay of growth and puberty.

  8. GnRH (show GNRH1 Proteins), through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 (show CYP11B2 Proteins) expression levels in some cases of aldosterone-producing adenoma.

  9. Studies of the gonadotrope suggest that extracellular regulatory loops may play a central role in the regulation of gonadotropin gene expression by gonadotropin-releasing hormone (GnRH) receptor activation.

  10. Interaction between ER-associated Hsp40s and the Vps34 (show PIK3C3 Proteins) complex permits the selective degradation of ERAD-resistant membrane protein GNRHR via ERQC autophagy.

Cow (Bovine) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. The GRIA1 (show GRIA1 Proteins) polymorphism exists in beef cows but it does not influence antral follicle numbers. The association between GnRHR genotype and age at first calving is likely not causal as this polymorphism is not functional.

  2. There was a significant correlation between frequency profile and timing of puberty among the studied breeds, which seems to suggest that genetic variation within bovine GNRHR gene could explain at least part of the reported variability.

  3. These results indicate that GnRHR gene can be a potential marker for improving sperm quality traits, and imply that bulls with GA or CT genotype should be selected in breeding program.

  4. Seven sequence variants (SVs) have been identified in exon 1 and in the promoter region upstream of the bovine gonadotrophin releasing hormone (GnRH) receptor; g.-108T>C alteration was associated with beneficial effects on fertility

GNRHR Protein Profile

Protein Summary

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Gene names and symbols associated with GNRHR

  • gonadotropin-releasing hormone receptor (GNRHR)
  • gonadotropin-releasing hormone receptor type I (gnrhr)
  • Gonadotropin-releasing hormone receptor (GRHR)
  • gonadotropin-releasing hormone receptor (CGNRH-R)
  • gonadotropin-releasing hormone receptor (AaeL_AAEL011325)
  • gonadotropin-releasing hormone receptor (gnrhr)
  • gonadotropin-releasing hormone receptor (gnrh-r)
  • GnRH receptor (LOC443413)
  • gonadotropin releasing hormone receptor (Gnrhr)
  • akhr protein
  • BEST:GH19447 protein
  • CG11325 protein
  • DAKHR protein
  • DAKHR-1 protein
  • DGRHR protein
  • Dmel\\CG11325 protein
  • GH1 protein
  • gnrh-r protein
  • GnRHR protein
  • GNRHR1 protein
  • GNRHR1/III protein
  • GNRHR2 protein
  • gnrhr3/ii protein
  • GRHR protein
  • GRHR/CG11325 protein
  • HH7 protein
  • LHRHR protein
  • LRHR protein
  • xgnrhr protein

Protein level used designations for GNRHR

gonadotropin-releasing hormone receptor , gonadotropin-releasing hormone receptor type I , AKH receptor , CG11325-PA , CG11325-PB , CG11325-PC , CG11325-PD , Drm-AKH receptor-1 , GRHR-PA , GRHR-PB , GRHR-PC , GRHR-PD , adipokinetic hormone receptor , gonadotrophin-releasing hormone receptor , hormone receptor , gonadotrophin releasing hormone receptor , gnoadotropin releasing hormone receptor 2 , gonadotropin-releasing hormone II receptor , type 1/III gonadotropin-releasing hormone receptor hexahelical , type 3/II gonadotropin-releasing hormone receptor , gnRH-R , gnRH receptor , growth hormone , gonadotropin releasing hormone receptor , gonadotropin-releasing hormone (type 1) receptor 1 , leutinizing hormone releasing horomone receptor , leutinizing-releasing hormone receptor , luliberin receptor , type I GnRH receptor , GnRH receptor , LHRH , luteinizing hormone-releasing hormone receptor , luteinizing-releasing hormone receptor , pituitary GnRH receptor , pituitary gonadotropin-releasing hormone receptor

GENE ID SPECIES
471226 Pan troglodytes
100009509 Oryctolagus cuniculus
100093333 Ornithorhynchus anatinus
100136208 Oncorhynchus mykiss
100589627 Nomascus leucogenys
33942 Drosophila melanogaster
395368 Gallus gallus
427517 Gallus gallus
5574685 Aedes aegypti
100135417 Xenopus (Silurana) tropicalis
100136028 Oncorhynchus mykiss
443413 Ovis aries
14715 Mus musculus
81668 Rattus norvegicus
100135532 Cavia porcellus
2798 Homo sapiens
403718 Canis lupus familiaris
397515 Sus scrofa
281798 Bos taurus
100033874 Equus caballus
711577 Macaca mulatta
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