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The product of GNLY is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. Additionally we are shipping Granulysin Kits (13) and Granulysin Proteins (10) and many more products for this protein.
Showing 10 out of 72 products:
Human Monoclonal GNLY Primary Antibody for FACS - ABIN2657203
Kaspar, Okada, Kumar, Poulain, Drouvalakis, Kelekar, Hanson, Kluck, Hitoshi, Johnson, Froelich, Thompson, Newmeyer, Anel, Clayberger, Krensky: A distinct pathway of cell-mediated apoptosis initiated by granulysin. in Journal of immunology (Baltimore, Md. : 1950) 2001
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Human Monoclonal GNLY Primary Antibody for FACS, IP - ABIN2663711
Krensky, Clayberger: Biology and clinical relevance of granulysin. in Tissue antigens 2009
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Human Monoclonal GNLY Primary Antibody for Func, FACS - ABIN2660773
Kalb, Glaser, Stary, Koszik, Stingl: TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. in Journal of immunology (Baltimore, Md. : 1950) 2012
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Human Polyclonal GNLY Primary Antibody for EIA, WB - ABIN952622
Xing, Wu, Wang, Krensky, Mody, Zheng: Granulysin production and anticryptococcal activity is dependent upon a far upstream enhancer that binds STAT5 in human peripheral blood CD4+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2010
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GNLY delivers Gzms into three protozoan parasites (Trypanosoma cruzi, Toxoplasma gondii and Leishmania major), in which the Gzms generate superoxide and inactivate oxidative defense enzymes to kill the parasite.
Studies indicate that cytotoxic mechanisms mediated by granulysin and TRAIL (TNF-related apoptosis inducing ligand (show TNFSF10 Antibodies)) seem to be less secondary effects on normal tissues.
High Granulysin expression is associated with Cutaneous T Cell Lymphoma and Sezary Syndrome.
A three-way interaction between SNPs in HLA-DQ and GNLY was identified in terms of HBV clearance.
GNLY-expressing lymphocytes, probably attracted by IL-15 (show IL15 Antibodies), not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leukocyte infiltration in patients with myocardial infarction.
Serum granulysin levels were significantly elevated in both acute and chronic alopecia areata patients.
Human, but not rodent, cytotoxic granules also contain granulysin, an antimicrobial peptide (show cAMP Antibodies) in addition to granzymes; study shows that granulysin delivers granzymes into bacteria to kill diverse bacterial strains.
It was concluded taht granulysin induces apoptosis on hematological tumor cells and on cells from B-cell lymphocytic leukemia patients, opening the door to research on its use as a new anti-tumoral treatment.
suggested that the alteration of circulating granulysin has potential function in host immune response against TB and HIV/TB coinfection
study to determine: expression of GNLY at the gene and protein levels at the maternal-fetal interface, relationship(s) between GNLY and perforin (show PRF1 Antibodies), and GNLY secretion by stimulated NK cells
Intercaruncular epithelium granulysin may play important roles in the establishment and maintenance of gestation during normal pregnancy.
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
, T-cell activation protein 519
, T-lymphocyte activation gene 519
, lymphocyte-activation gene 2
, lymphokine LAG-2