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The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. Additionally we are shipping GFER Kits (18) and GFER Proteins (18) and many more products for this protein.
Showing 10 out of 67 products:
Human Polyclonal GFER Primary Antibody for EIA, WB - ABIN952716
Dong, Sun, Jiang, Shao, Hu, Jiang, Wang, An: Epidermal growth factor down-regulates the expression of human hepatic stimulator substance via CCAAT/enhancer-binding protein β in HepG2 cells. in The Biochemical journal 2010
Show all 3 references for ABIN952716
Human Polyclonal GFER Primary Antibody for EIA, FACS - ABIN952717
Li, Zhang, An: The conserved CXXC motif of hepatic stimulator substance is essential for its role in mitochondrial protection in H2O2-induced cell apoptosis. in FEBS letters 2010
Show all 2 references for ABIN952717
FAT1 (show FAT1 Antibodies) protein acts upstream of Hippo signalling through TAZ (show TAZ Antibodies) protein to regulate neuronal differentiation.
ALR protects cells from apoptosis partly through increased autophagy in HepG2 cells.
Knockdown of GFER exerts anti-inflammatory actions via suppression of the mitogen-activated protein kinase (show MAPK1 Antibodies) signaling pathway
ALR plays a protective role against hydrogen peroxide-induced oxidative stress in renal proximal tubule cells.
Data show that the over-expression of 23 kDa augmenter of liver regeneration (ALR) in hepatic cell line LO2 cells promoted the cell proliferation and enhanced cell resistance to hydrogen peroxide.
Upregulation of miR (show MLXIP Antibodies)-130b enhances stem cell-like phenotype in glioblastoma by inactivating the Hippo signaling pathway.
In this review, we discuss the roles of non-canonical Hippo/Mst (show MAP3K10 Antibodies) signaling pathways in lymphocyte development and functions. [review]
ALR is involved in the progression of renal fibrosis and administration of rhALR protects the kidney against renal fibrosis by inhibition of TGF-beta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) activity.
Enhanced ALR gene expression was negatively correlated with advanced histopathological grade and stage in both colon cancer cell lines and human tissue samples.
A model for the functional defect in Erv1 R182H, which could potentially be extended to human ALR R194H and provides insights into the molecular basis of autosomal recessive myopathy.
this study shows that ALR can weaken ConA-induced hepatitis
ALR is apparently required to ensure appropriate liver regeneration following PH in mice, and deletion of the ALR gene may delay liver regeneration in part due to impaired mitochondrial biogenesis.
ALR can protect mice against acute liver injury by up-regulating the expression of regulatory T cells.
From weeks 2-4 after birth, levels of steatosis and apoptosis decreased in ALR-L-KO mice, and numbers of ALR-expressing cells increased, along with ATP level
As a mechanism, we suggest a direct protective effect of ALR on apoptotic and necrotic death of hepatocytes and an attenuation of inflammatory cell influx into the postischemic tissue.
ALR may serve as a potential diagnostic marker of hepatocellular stress and/or acute inflammatory conditions.
Growth factor erv1-like (Gfer) inhibits the COP9 (show COPS8 Antibodies) signalosome subunit jun activation-domain binding protein 1 (Jab1 (show COPS5 Antibodies))-mediated degradation of the cyclin-dependent kinase inhibitor p27(kip1 (show CDKN1B Antibodies)) to restrict proliferation of hematopoietic stem cells.
Gfer plays an essential pro-survival role in the maintenance of murine embryonic stem cell pluripotency by preserving the structural and functional integrity of their mitochondria, through modulation of the key mitochondrial fission factor (show MFF Antibodies) Drp1 (show CRMP1 Antibodies).
Growth factor erv1-like modulates Drp1 (show CRMP1 Antibodies) to preserve mitochondrial dynamics and function in mouse embryonic stem cells
studies demonstrated a specific accumulation of full-length mouse Alrp (show ANKRD1 Antibodies) during the early stages of spermatogenesis; the highest levels of Alrp (show ANKRD1 Antibodies) were found in spermatogonia and primary spermatocytes
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.
growth factor, augmenter of liver regeneration
, growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)
, FAD-linked sulfhydryl oxidase ALR
, ERV1 homolog
, erv1-like growth factor
, hepatic regenerative stimulation substance
, hepatopoietin protein
, augmenter of liver regeneration
, growth factor, erv1 homolog
, growth factor, erv1-like (augmenter of liver regeneration)