GFER antibody (AA 81-205)

Catalog No. ABIN7152531

Product Details anti-GFER Antibody

Target: GFER (Growth Factor, Augmenter of Liver Regeneration (GFER))

Binding Specificity: AA 81-205

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GFER antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human FAD-linked sulfhydryl oxidase ALR protein (81-205AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for GFER

Target: GFER (Growth Factor, Augmenter of Liver Regeneration (GFER))

Alternative Name: GFER (GFER Products)

Synonyms: ALR antibody, ERV1 antibody, HERV1 antibody, HPO antibody, HPO1 antibody, HPO2 antibody, HSS antibody, Alr antibody, growth factor, augmenter of liver regeneration antibody, growth factor, augmenter of liver regeneration L homeolog antibody, GFER antibody, Gfer antibody, gfer.L antibody

Background:

Background: Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration.

Aliases: ALR_HUMAN antibody, Augmenter of liver regeneration antibody, ERV1 antibody, ERV1 homolog antibody, Erv1 like growth factor antibody, FAD-linked sulfhydryl oxidase ALR antibody, GFER antibody, Growth factor augmenter of liver regeneration antibody, Growth factor erv1 like antibody, Hepatic regenerative stimulation substance antibody, Hepatopoietin antibody, Hepatopoietin protein antibody, hERV1 antibody, HPO antibody, HPO1 antibody, HPO2 antibody, HSS antibody

UniProt: P55789

Pathways: SARS-CoV-2 Protein Interactome