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Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 2 Proteins (GNAI2)

The protein encoded by GNAI2 is an alpha subunit of guanine nucleotide binding proteins (G proteins). Additionally we are shipping GNAI2 Antibodies (57) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNAI2 14678 P08752
GNAI2 2771 P04899
GNAI2 81664 P04897
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Top GNAI2 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Oryzias latipes His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,964.50
Details

GNAI2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,
Rat (Rattus)

Top referenced GNAI2 Proteins

  1. Human GNAI2 Protein expressed in Escherichia coli (E. coli) - ABIN1098399 : Damaj, McColl, Neote, Songqing, Ogborn, Hébert, Naccache: Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996 (PubMed)
    Show all 2 references for ABIN1098399

More Proteins for Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 2 (GNAI2) Interaction Partners

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 2 (GNAI2) interaction partners

  1. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  2. Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.

  3. An essential role for Galpha(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.

  4. Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo.

  5. Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (show RIC8A Proteins)) expression in hematopoietic cells results in a loss of GTP-binding protein (show DRG1 Proteins) alpha subunits Galphai2, Galphai3 (show GNAI3 Proteins), and Galphaq (show GNAQ Proteins).

  6. S1P (show S1PR1 Proteins) sensitizes ICAPS through G-protein coupled S1P1 (show S1PR1 Proteins) receptor activation of Galphai-PI3K-PKC-p38 (show CRK Proteins) signaling pathway in sensory neurons

  7. Myocardial ischemia promptly regulated cardiac mRNA and with a slight delay protein levels of both Galphai2 and Galphai3 (show GNAI3 Proteins), indicating important roles for both Galphai isoforms.

  8. RGS (show PITX2 Proteins) protein/Galphai2 interactions have an essential role in B lymphocyte (show AKAP17A Proteins)-directed cell migration and trafficking.

  9. Data (including data from knockout mice) suggest that Gnai2 in islet beta-cells is necessary for up-regulation of insulin (show INS Proteins) secretion in response to high glucose in presence of L-arginine (show GATM Proteins) or L-ornithine.

  10. The absence of Galphai2 and Galphai3 (show GNAI3 Proteins) in B cells profoundly disturbs the architecture of lymphoid organs with loss of B cell compartments in the spleen, thymus, lymph nodes, and gastrointestinal tract.

Human Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 2 (GNAI2) interaction partners

  1. Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.

  2. Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma.

  3. Galpha (show SUCLG1 Proteins)(i2) activates the TRPC4 (show TRPC4 Proteins) channel by direct binding.

  4. Changes in ion selectivity and pore dilation of the TRPC4 (show TRPC4 Proteins) channel elicited by the Galphai2 subunit, were studied.

  5. Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C - and histone deacetylase (show HDAC1 Proteins) -dependent manner

  6. These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 (show CACNA1A Proteins) Ca(2 (show CA2 Proteins)+) channels

  7. The ubiquitination of Galphai2 and Galphaq (show GNAQ Proteins) is suppressed by expression of Ric-8A (show RIC8A Proteins). The suppression likely requires Ric-8A (show RIC8A Proteins) interaction with these Galpha (show SUCLG1 Proteins) proteins; the C-terminal truncation of Galphaq (show GNAQ Proteins) and Galphai2 completely abrogates their interaction with Ric-8A (show RIC8A Proteins).

  8. Gialpha2 plays an essential role in OXT (show OXT Proteins) and EGF (show EGF Proteins) signaling to induce prostate cancer cell migration.

  9. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha (show SUCLG1 Proteins)(i2) for degradation through ubiquitination

  10. Galphai2 as a novel claudin-5 (show CLDN5 Proteins) partner required for TJ integrity in brain endothelial cells.

GNAI2 Protein Profile

Protein Summary

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.

Gene names and symbols associated with GNAI2

  • guanine nucleotide binding protein (G protein), alpha inhibiting 2 (Gnai2)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (Gnai2)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (gnai2)
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b (gnai2b)
  • C76432 protein
  • fi21e06 protein
  • Galphai2 protein
  • GBI2 protein
  • Gia protein
  • gip protein
  • Gnai-2 protein
  • gnai2 protein
  • gnai2b protein
  • gnai3 protein
  • H_LUCA15.1 protein
  • H_LUCA16.1 protein
  • wu:fi21e06 protein
  • zgc:56690 protein

Protein level used designations for GNAI2

adenylate cyclase-inhibiting G alpha protein , guanine nucleotide binding protein, alpha inhibiting 2 , guanine nucleotide-binding protein G(i) subunit alpha-2 , Gi2 protein alpha-subunit , GTP-binding regulatory protein Gi alpha-2 chain , guanine nucleotide-binding protein G(i), alpha-2 subunit , guanine nucleotide-binding regulatory protein alpha inhibitory subunit , Gi-alpha-2 protein , guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2 , guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2 , G alpha inhibitory type 2 (a) , G alpha inhibitory type 2 (b) , GTP-binding protein (G-alpha-i2) , guanine nucleotide binding protein (G protein), alpha inhibiting 2 , guanine nucleotide binding protein, alpha inhibiting 3 , Galpha i2a , guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 , guanine nucleotide-binding protein Gi2 alpha-subunit

GENE ID SPECIES
14678 Mus musculus
100135529 Cavia porcellus
2771 Homo sapiens
442957 Canis lupus familiaris
397523 Sus scrofa
281791 Bos taurus
81664 Rattus norvegicus
779438 Xenopus laevis
396367 Gallus gallus
327650 Danio rerio
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