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Guanylate Cyclase 1, Soluble, alpha 2 Proteins (GUCY1A2)

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. Additionally we are shipping GUCY1A2 Antibodies (16) and GUCY1A2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse GUCY1A2 GUCY1A2 234889  
GUCY1A2 2977 P33402
GUCY1A2 66012 Q9WVI4
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Top GUCY1A2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,132.33
Details

GUCY1A2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

More Proteins for Guanylate Cyclase 1, Soluble, alpha 2 (GUCY1A2) Interaction Partners

Mouse (Murine) Guanylate Cyclase 1, Soluble, alpha 2 (GUCY1A2) interaction partners

  1. These data suggests a novel physiological role for PDE5 (show PDE5A Proteins) in restricting the effects of NOS3 (show NOS3 Proteins)/sGC (show NPR1 Proteins)/PKG (show PRKG1 Proteins) signaling pathway to modulating beta-AR stimulated I(Ca), while limiting effects on cardiac contraction.[sGC (show NPR1 Proteins)]

  2. Requirement of both alpha-2 and alpha-1 guanylate cyclases for signaling in long-term potentiation (LTP (show SCP2 Proteins)) indicates the existence of two distinct nitric oxide/cGMP-mediated pathways, which have to work in concert for expression of LTP (show SCP2 Proteins).

  3. The aim of this study was to investigate the role of Gucy1a2 in nitrergic regulation of gastric motility in male and female Gucy1a2 knock-out mice.

Human Guanylate Cyclase 1, Soluble, alpha 2 (GUCY1A2) interaction partners

  1. The data support a novel regulatory mechanism whereby sGC (show SGCB Proteins) activity is tuned by distinct domain interactions that either promote or inhibit catalytic activity.

  2. The CO binding affinity of soluble guanylate cyclase alpha 2 subunit is threefold greater than that of human soluble guanylate cyclase alpha 1 subunit.

  3. The sGC (show SGCB Proteins) alpha 1observed in OVCAR-3 and MDA-MB-468 cancer cells which correlated well with the sGC (show SGCB Proteins) activity and a marked increase in cGMP levels upon exposure to the combination of a NO donor and a sGC (show SGCB Proteins) activator.

  4. Soluble guanylyl cyclase (sGC (show SGCB Proteins)) is the major cellular receptor for the intercellular messenger nitric oxide (NO) and mediates a wide range of physiological effects through elevation of intracellular cGMP levels

  5. No significant changes were found in sGC (show SGCB Proteins) subunit mRNAs in people with schizophrenia or in controls.

GUCY1A2 Protein Profile

Protein Summary

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GUCY1A2

  • guanylate cyclase 1, soluble, alpha 2 (Gucy1a2)
  • guanylate cyclase 1, soluble, alpha 2 (GUCY1A2)
  • guanylate cyclase 1, soluble, alpha 2 (gucy1a2)
  • guanylate cyclase 1, soluble, alpha 2 (LOC100357621)
  • 6330407I18Rik protein
  • A230060L24Rik protein
  • GC-SA2 protein
  • GUC1A2 protein
  • GUCY1A2 protein

Protein level used designations for GUCY1A2

guanylate cyclase 1, soluble, alpha 2 , guanylate cyclase soluble subunit alpha-2 , guanylate cyclase soluble subunit alpha-2-like , GCS-alpha-2 , soluble guanylyl cyclase alpha2 subunit

GENE ID SPECIES
234889 Mus musculus
466769 Pan troglodytes
479455 Canis lupus familiaris
613600 Bos taurus
771678 Gallus gallus
100145454 Xenopus (Silurana) tropicalis
100294640 Ovis aries
100357621 Oryctolagus cuniculus
100387768 Callithrix jacchus
100445361 Pongo abelii
100464538 Ailuropoda melanoleuca
100522091 Sus scrofa
706615 Macaca mulatta
100542159 Meleagris gallopavo
100554615 Anolis carolinensis
2977 Homo sapiens
66012 Rattus norvegicus
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