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anti-Guanylate Cyclase Activator 1A (Retina) (GUCA1A) Antibodies

GUCA1A plays a role in the recovery of retinal photoreceptors from photobleaching. Additionally we are shipping Guanylate Cyclase Activator 1A (Retina) Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GUCA1A 2978 P43080
GUCA1A 14913 P43081
GUCA1A 301233  
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Top anti-Guanylate Cyclase Activator 1A (Retina) Antibodies at antibodies-online.com

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-GUCA1A Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-GCAP1 C-term Pab (ABIN388395) is used in Western blot to detect GCAP1 in Y79 cell lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated RNAi, ELISA, WB Western Blot analysis of GUCA1A expression in transfected 293T cell line by GUCA1A monoclonal antibody (M04), clone 2F7.Lane 1: GUCA1A transfected lysate(22.9 KDa).Lane 2: Non-transfected lysate. Western blot analysis of GUCA1A over-expressed 293 cell line, cotransfected with GUCA1A Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with GUCA1A monoclonal antibody (M04), clone 2F7. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB GUCA1A antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.34 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

GUCA1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Guanylate Cyclase Activator 1A (Retina) Antibodies

  1. Human Polyclonal GUCA1A Primary Antibody for EIA, IHC (p) - ABIN357117 : Pennesi, Howes, Baehr, Wu: Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 3 references for ABIN357117

  2. Chicken Polyclonal GUCA1A Primary Antibody for WB - ABIN2785648 : Michaelides, Wilkie, Jenkins, Holder, Hunt, Moore, Webster: Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy. in Ophthalmology 2005 (PubMed)

More Antibodies against Guanylate Cyclase Activator 1A (Retina) Interaction Partners

Human Guanylate Cyclase Activator 1A (Retina) (GUCA1A) interaction partners

  1. Retinal dystrophy-associated missense mutations (L84F, I107T) in GUCA1A with distinct molecular properties result in a similar aberrant regulation of the retinal guanylate cyclase.

  2. Dimerization domain of RETGC1 (show GUCY2D Antibodies) is an essential part of GCAP1 and GCAP2 (show GUCA1B Antibodies) binding interface.

  3. The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1.

  4. GUCA1A and GUCY2D (show GUCY2D Antibodies) mutations are both accompanied by similar pattern of generalized cone dysfunction with a tendency to less involvement of the rod photoreceptors and a less severe phenotype in patients with GUCA1A.

  5. RetGC1 (show GUCY2D Antibodies) activation by GCAP1 involves establishing a tight complex through the binding patch with an additional activation step involving Met-26, Lys (show LYZ Antibodies)-85, and Trp (show TBPL1 Antibodies)-94.

  6. All four mutant GCAP1 family members showed sensitivity or acuity losses relative to normal observers.

  7. we predicted that either haploinsufficiency or dominant-negative effect accompanied by creation of a novel function for the mutant protein is a possible mechanism of the retinal degeneration due to c.250C>T and c.320T>C of the GUCA1A

  8. Patients with autosomal dominant cone-rod dystrophy caused by a D100G mutation in GUCA1A exhibit progressive vision loss early within the first decade of life identifiable by distinct ERG (show ERG Antibodies).

  9. the GUCA1A mutation only contributes to a small portion of CORD in people of Chinese descent.

  10. Stimulation by GCAP (show ALPPL2 Antibodies) increases the maximal velocity (Vmax) for retinal guanylyl cyclase activat (show GUCY2D Antibodies)ion up to 100-fold in HEK293 cell membranes.

Cow (Bovine) Guanylate Cyclase Activator 1A (Retina) (GUCA1A) interaction partners

  1. Data suggest that GCAP1 (Mg2 (show MCOLN1 Antibodies)+ vs. Ca2 (show CA2 Antibodies)+) exhibits conformational changes in Ca2 (show CA2 Antibodies)+ switch helix that are important in activation of RetGC1 (show GUCY2D Antibodies) (photoreceptor guanylate cyclase); myristoylation of GCAP1 is important as well in attaining activator conformation.

  2. Data suggest that dimerization domain of GUCY2D (show GUCY2D Antibodies) operates as a calcium-sensitive regulatory module; GUCY2D (show GUCY2D Antibodies) requires correct conformation of monomer-monomer interface for interaction with guanylate cyclase activating proteins (GCAP1; GCAP2 (show GUCA1B Antibodies)).

  3. Presence of bound magnesium (Mg2 (show MCOLN1 Antibodies)+) in guanylate cyclase activator (show RCVRN Antibodies) protein GCAP-1 is essential for its ability to stimulate retinal guanylyl cyclase.

Mouse (Murine) Guanylate Cyclase Activator 1A (Retina) (GUCA1A) interaction partners

  1. The GCAP1 and GCAP2 binding site(s) overlaps within the kinase homology and/or dimerization domains of retinal GC1.

  2. Direct association between RD3 and GCAP1 is important for GC1 targeting.

  3. The wild type and mutants of GCAP1 displayed large differences in Ca(2 (show CA2 Antibodies)+)-binding and regulation and preserved an intact secondary and tertiary structure with a significant rearrangement of the aromatic residues upon binding of Ca(2 (show CA2 Antibodies)+).

  4. GCAP1 is the 'first-response' sensor protein that stimulates retinal membrane guanylyl cyclase early in the rod photoresponse.

  5. results argue that there must be a cellular mechanism that limits GCAP1 access to RetGC2 (show GUCY2F Antibodies) and makes RetGC1 (show GUCY2D Antibodies) isozyme a preferential target for the disease-causing GCAP1 mutants.

  6. Recombinant Gcap14 protein cosedimented with pure microtubules, indicating a direct binding between the two

  7. Calcium-myristoyl Tug (show ASPSCR1 Antibodies) is a new mechanism for intramolecular tuning of calcium sensitivity and target enzyme interaction for guanylyl cyclase-activating protein 1

  8. Stimulation by GCAP increases the maximal velocity (Vmax) for retinal guanylyl cyclase (RetGC1 (show GUCY2D Antibodies)) activation up to 20-fold in mouse photoreceptor outer segment.

  9. GCAP-activated native retinal membrane (Ret (show RET Antibodies))GC1 and RetGC2 (show GUCY2F Antibodies) are less sensitive to inhibition by calcium ions in the presence of GCAP1 than GCAP2 (show GUCA2B Antibodies).

  10. Mutant GCAP1, when under normal expression control, causes both rod and cone photoreceptors to lose function and degenerate, with cone cells being more severely affected, in keeping with the human disease phenotype.

Guanylate Cyclase Activator 1A (Retina) (GUCA1A) Antigen Profile

Protein Summary

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3)\; a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations\; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.

Gene names and symbols associated with GUCA1A

  • guanylate cyclase activator 1A (retina) (guca1a) antibody
  • guanylate cyclase activator 1A (retina) (GUCA1A) antibody
  • guanylate cyclase activator 1A (retina) (LOC100224057) antibody
  • guanylate cyclase activator 1a (retina) (Guca1a) antibody
  • guanylate cyclase activator 1C (GUCA1C) antibody
  • C6orf131 antibody
  • COD3 antibody
  • CORD14 antibody
  • dJ139D8.6 antibody
  • GC-A antibody
  • GCAP antibody
  • Gcap1 antibody
  • GUCA antibody
  • Guca1 antibody
  • guca1a antibody
  • MGC84170 antibody
  • MGC146317 antibody
  • mGCAP1 antibody

Protein level used designations for GUCA1A

guanylate cyclase activator 1A (retina) , GCAP 1 , cone dystrophy 3 , guanylate cyclase-activating protein, photoreceptor 1 , guanylin 1, retina , guanylyl cyclase-activating protein 1

GENE ID SPECIES
444645 Xenopus laevis
748651 Pan troglodytes
779962 Xenopus (Silurana) tropicalis
100224057 Taeniopygia guttata
2978 Homo sapiens
282243 Bos taurus
14913 Mus musculus
301233 Rattus norvegicus
374216 Gallus gallus
609180 Canis lupus familiaris
427960 Gallus gallus
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