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HCLS1 Associated Protein X-1 Proteins (HAX1)

The protein encoded by HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. Additionally we are shipping HAX1 Antibodies (146) and HAX1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAX1 10456 O00165
Rat HAX1 HAX1 291202 Q7TSE9
HAX1 23897 O35387
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Top HAX1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag HCLS1 Associated Protein X-1 (HAX1) (AA 2-250), (partial) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,728.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HAX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced HAX1 Proteins

  1. Human HAX1 Protein expressed in Escherichia coli (E. coli) - ABIN1098543 : Klein, Grudzien, Appaswamy, Germeshausen, Sandrock, Schäffer, Rathinam, Boztug, Schwinzer, Rezaei, Bohn, Melin, Carlsson, Fadeel, Dahl, Palmblad, Henter, Zeidler, Grimbacher, Welte: HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). in Nature genetics 2006 (PubMed)
    Show all 2 references for ABIN1098543

More Proteins for HCLS1 Associated Protein X-1 (HAX1) Interaction Partners

Human HCLS1 Associated Protein X-1 (HAX1) interaction partners

  1. Kv3.3 (show KCNC3 Proteins) regulates Arp2 (show ACTR2 Proteins)/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia (show USP14 Proteins) type 13.

  2. Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibits cell apoptosis through caspase-9 (show CASP9 Proteins) inactivation.

  3. HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation.

  4. HAX1 knockdown significantly decreased the proliferation. In addition, the expression levels of ki67 (show MKI67 Proteins) and phosphorylatedakt were inhibited following HAX1 knockdown.

  5. HAX-1 was significantly elevated in laryngeal carcinoma.

  6. Authors showed that HAX1 promotes auto-ubiquitination and degradation of cIAPs by facilitating the intermolecular homodimerization of RING finger (show PCGF1 Proteins) domain.

  7. HAX-1 is involved in mRNA processing as an element of P-body interaction network.

  8. HAX1 mutation is associated with severe congenital neutropenia.

  9. HAX1 is a proto-oncogene (show RAB1A Proteins) in mantle cell lymphoma.

  10. anti-apoptotic role of HAX-1 versus BCL-XL (show BCL2L1 Proteins) in cytokine-dependent bone marrow-derived cells

Mouse (Murine) HCLS1 Associated Protein X-1 (HAX1) interaction partners

  1. The hydrophilic sequences within loop 2, and the matrix-localized hydrophilic domain of UCP3, were necessary for binding to Hax-1 at the C-terminal domain, adjacent to the mitochondrial inner membrane.

  2. Protease Omi (show HTRA2 Proteins) impairs mitochondrial function by cleaving Hax-1, which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.

  3. Knockdown of HAX1 and EB2 (show MAPRE2 Proteins) in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration.

  4. These findings reveal the role of HAX-1 in regulating cyclophilin-D (show PPIF Proteins) levels via an Hsp90 (show HSP90 Proteins)-dependent mechanism, resulting in protection against activation of mPTP (show PTPN2 Proteins) and subsequent cell death responses.

  5. anti-apoptotic role of HAX-1 versus BCL-XL (show BCL2L1 Proteins) in cytokine-dependent bone marrow-derived cells

  6. The expression of Hax-1 in normal brain tissue and reduction of Hax-1 in ischemic brain tissue indicate its possible involvement in pathophysiological functions in the brain.

  7. Cardiac ischemia-reperfusion injury is associated with decreases in HAX-1 levels. Overexpression of HAX-1 promotes cardiomyocyte survival, via its interaction with Hsp90 (show HSP90 Proteins) and specific inhibition of IRE-1 (show ERN1 Proteins) signaling at the ER/sarcoplasmic reticulum.

  8. Focal cerebral ischemia significantly decreased cytosolic accumulation of HAX-1, induced an upregulation of HtrA2 (show HTRA2 Proteins), an upregulation of AIF (show AIFM1 Proteins) and activation of caspase-3 (show CASP3 Proteins)

  9. HAX1 deficiency: impact on lymphopoiesis and B-cell development.

  10. HAX-1 is a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated (show NSDHL Proteins) muscle cells

HAX1 Protein Profile

Protein Summary

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with HAX1

  • HCLS1 associated protein X-1 (HAX1)
  • HCLS1-associated protein X-1 (hax1)
  • zgc:92196 (zgc:92196)
  • HCLS1 associated protein X-1 (LOC100348155)
  • HCLS1 associated protein X-1 (Hax1)
  • HCLS1 associated X-1 (Hax1)
  • HAX-1 protein
  • hax1 protein
  • HCLSBP1 protein
  • Hs1bp1 protein
  • HSP1BP-1 protein
  • mHAX-1s protein
  • SCN3 protein
  • SIG-111 protein
  • Silg111 protein

Protein level used designations for HAX1

HCLS1 associated protein X-1 , HCLS1-associated protein X-1 , HAX-1 , HCLS1 (and PKD2) associated protein , HS1 binding protein , HS1-associating protein X-1 , HS1-binding protein 1 , HSP1BP-1 , HS1-associated protein X-1

GENE ID SPECIES
457347 Pan troglodytes
100194877 Salmo salar
436609 Danio rerio
100348155 Oryctolagus cuniculus
10456 Homo sapiens
480134 Canis lupus familiaris
506895 Bos taurus
291202 Rattus norvegicus
23897 Mus musculus
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