HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase Proteins (HUWE1)

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. Additionally we are shipping HUWE1 Antibodies (69) and HUWE1 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HUWE1 10075 Q7Z6Z7
Mouse HUWE1 HUWE1 59026 Q7TMY8
HUWE1 501546  
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Top HUWE1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,865.50
Details

HUWE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

More Proteins for HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Interaction Partners

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. Mule also regulates protein levels of the receptor tyrosine kinase (show ERBB3 Proteins) EphB3 (show EPHB3 Proteins) by targeting it for proteasomal and lysosomal degradation.

  2. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  3. TNF (show TNF Proteins) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (show SYK Proteins) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Proteins)-induced JNK (show MAPK8 Proteins) activation and cell death.

  4. expression level of miR (show MLXIP Proteins)-98, which can regulate Caspase-3 (show CASP3 Proteins), was significantly decreased. Huwe1, the host gene of miR (show MLXIP Proteins)-98, was positively associated with miR (show MLXIP Proteins)-98 expression after Silica NP exposure

  5. Thus, modulating the levels of both Huwe1 and USP10 (show USP10 Proteins) appears to fine-tune the requisite degradation of TBP (show TBP Proteins) during myogenesis.

  6. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  7. The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.

  8. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (show MYC Proteins)/Miz1 (show PIAS2 Proteins) complexes that mediates p21 and p15 (show CDKN2B Proteins) down-regulation

  9. an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.

  10. Mule regulates the ATM (show ATM Proteins)-p53 (show TP53 Proteins) axis to maintain B cell homeostasis under both steady-state and stress conditions.

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) interaction partners

  1. HUWE1 is essential for genomic stability, by promoting replication of damaged DNA We show that HUWE1-knockout cells are unable to mitigate replication stress, resulting in replication defects and DNA breakage.

  2. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion.

  3. The interaction with Huwe1 and polyubiquitylation were blocked by disruption of casein kinase 1 (CK1 (show CSNK1A1 Proteins)) activity, and mass spectrometry and mutational analysis identified serine 334 as an important phosphorylation site for Atoh1 (show ATOH1 Proteins) ubiquitylation and subsequent degradation.

  4. Elevated HECTH9 protein expression is associated with pathogenesis of hepatocellular carcinoma.

  5. Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.

  6. We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.

  7. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

  8. miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.

  9. TNF (show TNF Proteins) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (show SYK Proteins) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (show TNF Proteins)-induced JNK (show MAPK8 Proteins) activation and cell death.

  10. HUWE1 and NEDD4-1 (show NEDD4 Proteins) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (show ABCG1 Proteins) and ABCG4 (show ABCG4 Proteins) protein levels and cellular cholesterol export activity

HUWE1 Protein Profile

Protein Summary

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Gene names and symbols associated with HUWE1

  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1)
  • HECT, UBA and WWE domain containing 1 (Huwe1)
  • HECT, UBA and WWE domain containing 1 (HUWE1)
  • HECT, UBA and WWE domain containing 1 (huwe1)
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1)
  • 5430439H10Rik protein
  • arf-bp1 protein
  • AU041296 protein
  • C80292 protein
  • C430014N20Rik protein
  • Gm1718 protein
  • hecth9 protein
  • hspc272 protein
  • Huwe1 protein
  • ib772 protein
  • lasu1 protein
  • mule protein
  • si:dkey-242a8.2 protein
  • URE-B1 protein
  • ureb1 protein

Protein level used designations for HUWE1

ARF-binding protein 1 , BJ-HCC-24 tumor antigen , E3 ubiquitin-protein ligase HUWE1 , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , URE-binding protein 1 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1 , upstream regulatory element-binding protein 1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , upstream regulatory element binding protein 1 , HECT, UBA and WWE domain containing 1 , rp3-339a18.4 , e3 ubiquitin-protein ligase HUWE1-like

GENE ID SPECIES
10075 Homo sapiens
59026 Mus musculus
465650 Pan troglodytes
480931 Canis lupus familiaris
511826 Bos taurus
559439 Danio rerio
700136 Macaca mulatta
100060375 Equus caballus
100123214 Nasonia vitripennis
100126217 Xenopus (Silurana) tropicalis
100380641 Salmo salar
100483129 Ailuropoda melanoleuca
100563451 Anolis carolinensis
501546 Rattus norvegicus
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