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HNF1B encodes a member of the homeodomain-containing superfamily of transcription factors. Additionally we are shipping HNF1 Homeobox B Kits (26) and HNF1 Homeobox B Proteins (8) and many more products for this protein.
Showing 10 out of 127 products:
Dog (Canine) Monoclonal HNF1B Primary Antibody for IF, WB - ABIN968855
De Simone, De Magistris, Lazzaro, Gerstner, Monaci, Nicosia, Cortese: LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. in The EMBO journal 1991
Show all 3 references for ABIN968855
Human Polyclonal HNF1B Primary Antibody for ELISA, WB - ABIN334505
Terasawa, Toyota, Sagae, Ogi, Suzuki, Sonoda, Akino, Maruyama, Nishikawa, Imai, Shinomura, Saito, Tokino: Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. in British journal of cancer 2006
Show all 2 references for ABIN334505
Human Polyclonal HNF1B Primary Antibody for WB - ABIN871758
Lindner, Njolstad, Horikawa, Bostad, Bell, Sovik: A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1beta. in Human molecular genetics 1999
Show all 2 references for ABIN871758
Chicken Polyclonal HNF1B Primary Antibody for WB - ABIN2779562
Wu, Bohn, Ryffel: The HNF1beta transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations. in European journal of biochemistry / FEBS 2004
Human Polyclonal HNF1B Primary Antibody for EIA, WB - ABIN952765
Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. in Diabetes 2010
Cow (Bovine) Polyclonal HNF1B Primary Antibody for EIA, IF - ABIN375249
Arenas, Hervias, Uriz, Joplin, Prieto, Medina: Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. in The Journal of clinical investigation 2008
Dog (Canine) Polyclonal HNF1B Primary Antibody for WB - ABIN2777700
Hakonarson, Qu, Bradfield, Marchand, Kim, Glessner, Grabs, Casalunovo, Taback, Frackelton, Eckert, Annaiah, Lawson, Otieno, Santa, Shaner, Smith, Onyiah, Skraban, Chiavacci, Robinson, Stanley, Kirsch et al.: A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. ... in Diabetes 2008
HNF1B mutations are associated with Maturity onset diabetes of youth.
along with Sanger genetic screening for MODY genetic testing, we were able to diagnose the aetiology of the first case of MODY caused by an HNF1B whole-gene deletion in a Brazilian patient with atypical clinical presentation.
We were able to diagnose the first Brazilian patient with an HNF1B whole-gene deletion, whose familial phenotype was not typically associated with this molecular diagnosis.
HNF-1B-positive malignant cells could be bipotential cells and give rise to both hepatocytic and cholangiocytic lineages during tumorigenesis.
Early-stage ovarian clear cell carcinoma tended to have high levels of HNF-1beta immunoreactivity. Low-level HNF-1beta expression was observed in patients with recurrence and high-level HNF-1beta was associated with good prognosis.
rs4430796 polymorphism of HNF1B gene influences independently the prognosis of EC patients with a potential effect on tumor chemo-sensitivity.
Combining HNF-1beta and napsin A (show NAPSA Antibodies) may distinguish clear cell carcinoma from high-grade serous carcinoma, endometrioid adenocarcinoma and metastatic Krukenberg tumors.
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies.
HNF1B score was discriminatory for HNF1B mutations in a large cohort of individuals tested in a single UK centre
In cervical carcinoma, expression of HNF-1beta is mostly restricted to adenocarcinomas and can be used as an auxiliary adenocarcinoma marker in the differential diagnosis of poorly differentiated cervical carcinomas.
Overexpression of two mutant HNF1B derivatives resulted in distinct phenotypes reflected by either a reduction or an enlargement of pronephros size.
nephrogenic transcription factors (osr1 (show OSR1 Antibodies), osr2, hnf1b, lhx1 (show LHX1 Antibodies), pax8 (show PAX8 Antibodies))play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA Antibodies), retinoic acid
CHOP (GADD153 (show DDIT3 Antibodies)) is an inhibitor of Wnt (show WNT2 Antibodies)/TCF (show HNF4A Antibodies) signals
HNF-1beta Regulates MicroRNA-200 Expression through a Long Noncoding RNA
TNFalpha (show TNF Antibodies) regulates uromodulin (show UMOD Antibodies) expression in a homeostatic setting, but the impact of TNFalpha (show TNF Antibodies) on uromodulin (show UMOD Antibodies) during kidney injury is superseded by other factors that could inhibit HNF1beta-mediated expression of uromodulin (show UMOD Antibodies).
Hypoxia induced early up-regulation of Hnf-1beta from 1 to 24 hours, independently of the hypoxia-inducible factor Hif-1alpha (show HIF1A Antibodies).
Zyxin (show ZYX Antibodies) regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta.
HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch (show NOTCH1 Antibodies) signalling components and Irx1 (show IRX1 Antibodies)/2.
identification of Hnf1b as a target of miR (show MLXIP Antibodies)-802-dependent silencing; show that short hairpin RNA (shRNA)-mediated reduction of Hnf1b in liver causes glucose intolerance, impairs insulin (show INS Antibodies) signalling and promotes hepatic gluconeogenesis
Hnf1b and Pax2 (show PAX2 Antibodies) operate to control kidney morphogenesis and ureter differentiation.
Overexpression of HNF1beta resulted in accelerated cell proliferation with the protein level up-regulation of plasminogen (show PLG Antibodies) and plasmin (show PLG Antibodies), a converted active form of plasminogen (show PLG Antibodies), which play a pivotal role in liver regeneration inducing hepatocyte proliferation.
Data indicate that HNF1alpha (show HNF1A Antibodies) is a more potent activator of AFM (show AFM Antibodies) promoter than is HNF1beta.
Study identifies new direct target genes of the Hnf1b transcription factors and shows that they play crucial roles in both defining cell fate and controlling terminal functions in the gut (show GUSB Antibodies) epithelium.
Data show that hnf1ba generates a permissive domain for Wnt (show WNT2 Antibodies) signaling activity in the foregut endoderm
Knockdown of pk1a led to decreased expression of vhnf1, a homeodomain gene previously shown to be involved in biliary development and in kidney cyst formation; forced expression of vhnf1 mRNA led to rescue of the pk1a morphant phenotype
Data show that vhnf1 functions in two ways to subdivide the zebrafish caudal (show CAD Antibodies) hindbrain domain (r4-r7) into individual rhombomeres.
Zebrafish tcf2 gene, composed of 9 exons, was mapped to linkage group LG15.
vhnf1 acts largely independently of val to repress the rhombomere 4 'hox (show MSH2 Antibodies) code' posterior to the rhombomere 4-5 boundary
Vhnf1 expression within the posterior neural tube (up to r5) promotes posterior and dorsal fates in the otic vesicle, at the expense of anterior and ventral fates.
investigated the signaling pathways that regulate vhnf1 expression during pancreas development
Data show that zebrafish mutants for Tcf2 fail to specify a single lumen in their gut (show GUSB Antibodies) tube and instead develop multiple lumens, and show that Tcf2 controls single lumen formation by regulating claudin15 and Na+/K+-ATPase (show ATP1A1 Antibodies) expression.
vHNF1 plays crucial role at the earliest steps of liver induction: the acquisition of endoderm competence and the hepatic specification.
It was concluded that hnf1b(hi2169) is hypomorphic to hnf1b(hi1843) and that, while hnf1b is required for r5/r6 gene expression in the hindbrain, r5/r6 gene expression can be experimentally induced independently of hnf1b anterior to the hindbrain.
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
, HNF1 homeobox B
, HNF1 beta A
, hepatocyte nuclear factor 1-beta
, homeoprotein LFB3
, transcription factor 2, hepatic
, FPC-binding protein
, variant hepatic nuclear factor 1
, hepatocyte nuclear factor-1 beta
, transcription factor 2
, Transcription factor 2 hepatic
, Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor
, Transcription factor 2, hepatic
, Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor
, hepatocyte nuclear factor 1 beta
, HNF1 homeobox b
, hepatocyte nuclear factor 1-beta-2
, hepatocyte nuclear factor 1-beta-A